The Characteristics and Outcomes of Patients Treated with Percutaneous Nephrolithotomy According to the Preoperative Renal Function Levels

Introduction The principles of nephrolithiasis therapy in patients with chronic kidney disease are the same as in patients with normal kidneys. Percutaneous nephrolithotomy (PNL) is the standard treatment for patients with complex or large-volume upper urinary tract calculi. We reported the charact...

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Autores principales:	Shahram Shabaninia, Seyed Reza Yahyazadeh, Arman Mousavi, Amir Kasaeian
Formato:	article
Lenguaje:	EN
Publicado:	Urology Research Center 2020
Materias:	nephrolithiasis renal insufficiency chronic nephrolithotomy percutaneous Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/1453601785d34be0aa5724ee598e76f6
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spelling	oai:doaj.org-article:1453601785d34be0aa5724ee598e76f62021-11-27T07:45:44ZThe Characteristics and Outcomes of Patients Treated with Percutaneous Nephrolithotomy According to the Preoperative Renal Function Levels10.22034/TRU.2020.239119.10252717-042Xhttps://doaj.org/article/1453601785d34be0aa5724ee598e76f62020-02-01T00:00:00Zhttps://www.transresurology.com/article_114223.htmlhttps://doaj.org/toc/2717-042XIntroduction The principles of nephrolithiasis therapy in patients with chronic kidney disease are the same as in patients with normal kidneys. Percutaneous nephrolithotomy (PNL) is the standard treatment for patients with complex or large-volume upper urinary tract calculi. We reported the characteristics and outcomes of patients following percutaneous nephrolithotomy according to their preoperative renal function levels. Methods In this prospective cohort study, data on 53 consecutive patients treated with percutaneous nephrolithotomy in 6 months were collected. Patients were divided into 3 groups by estimated glomerular filtration rate (eGFR) including chronic kidney disease (CKD) stages 0, 1 and 2 (eGFR ≥ 60 mL/min/1.73 m2), stage 3 (eGFR = 30 to 59 mL/min/1.73 m2) and stages 4 and 5 (eGFR < 30 mL/min/1.73 m2). Results 31 patients with CKD stages 0, 1, and 2, 17 patients with CKD stage 3, and 5 patients with stages 4 and 5 were followed up for at least three months. The mean eGFR before and after PNL was 80.1 vs. 85.9, 47.6 vs. 49.1, and 23.5 vs. 23.4 mL/min/1.73 m2 in the mild, moderate, and severe CKD groups, respectively. Based on the statistical analysis, eGFR in the mild group had been significantly increased compared to the other groups, whereas there was no considerable difference between the moderate and severe groups. Conclusions By the removal of kidney stones, the progression of CKD may be halted. While significant improvement was observed in early-stage CKD, sometimes unexpected deterioration could occur in patients at the end stages of renal diseases.Shahram Shabaninia Seyed Reza YahyazadehArman MousaviAmir KasaeianUrology Research Centerarticlenephrolithiasisrenal insufficiencychronicnephrolithotomypercutaneousDiseases of the genitourinary system. UrologyRC870-923ENTranslational Research in Urology, Vol 2, Iss 1, Pp 4-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	nephrolithiasis renal insufficiency chronic nephrolithotomy percutaneous Diseases of the genitourinary system. Urology RC870-923
spellingShingle	nephrolithiasis renal insufficiency chronic nephrolithotomy percutaneous Diseases of the genitourinary system. Urology RC870-923 Shahram Shabaninia Seyed Reza Yahyazadeh Arman Mousavi Amir Kasaeian The Characteristics and Outcomes of Patients Treated with Percutaneous Nephrolithotomy According to the Preoperative Renal Function Levels
description	Introduction The principles of nephrolithiasis therapy in patients with chronic kidney disease are the same as in patients with normal kidneys. Percutaneous nephrolithotomy (PNL) is the standard treatment for patients with complex or large-volume upper urinary tract calculi. We reported the characteristics and outcomes of patients following percutaneous nephrolithotomy according to their preoperative renal function levels. Methods In this prospective cohort study, data on 53 consecutive patients treated with percutaneous nephrolithotomy in 6 months were collected. Patients were divided into 3 groups by estimated glomerular filtration rate (eGFR) including chronic kidney disease (CKD) stages 0, 1 and 2 (eGFR ≥ 60 mL/min/1.73 m2), stage 3 (eGFR = 30 to 59 mL/min/1.73 m2) and stages 4 and 5 (eGFR < 30 mL/min/1.73 m2). Results 31 patients with CKD stages 0, 1, and 2, 17 patients with CKD stage 3, and 5 patients with stages 4 and 5 were followed up for at least three months. The mean eGFR before and after PNL was 80.1 vs. 85.9, 47.6 vs. 49.1, and 23.5 vs. 23.4 mL/min/1.73 m2 in the mild, moderate, and severe CKD groups, respectively. Based on the statistical analysis, eGFR in the mild group had been significantly increased compared to the other groups, whereas there was no considerable difference between the moderate and severe groups. Conclusions By the removal of kidney stones, the progression of CKD may be halted. While significant improvement was observed in early-stage CKD, sometimes unexpected deterioration could occur in patients at the end stages of renal diseases.
format	article
author	Shahram Shabaninia Seyed Reza Yahyazadeh Arman Mousavi Amir Kasaeian
author_facet	Shahram Shabaninia Seyed Reza Yahyazadeh Arman Mousavi Amir Kasaeian
author_sort	Shahram Shabaninia
title	The Characteristics and Outcomes of Patients Treated with Percutaneous Nephrolithotomy According to the Preoperative Renal Function Levels
title_short	The Characteristics and Outcomes of Patients Treated with Percutaneous Nephrolithotomy According to the Preoperative Renal Function Levels
title_full	The Characteristics and Outcomes of Patients Treated with Percutaneous Nephrolithotomy According to the Preoperative Renal Function Levels
title_fullStr	The Characteristics and Outcomes of Patients Treated with Percutaneous Nephrolithotomy According to the Preoperative Renal Function Levels
title_full_unstemmed	The Characteristics and Outcomes of Patients Treated with Percutaneous Nephrolithotomy According to the Preoperative Renal Function Levels
title_sort	characteristics and outcomes of patients treated with percutaneous nephrolithotomy according to the preoperative renal function levels
publisher	Urology Research Center
publishDate	2020
url	https://doaj.org/article/1453601785d34be0aa5724ee598e76f6
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The Characteristics and Outcomes of Patients Treated with Percutaneous Nephrolithotomy According to the Preoperative Renal Function Levels

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