Salivary microbiome with gastroesophageal reflux disease and treatment

Abstract The effect of oral microbial composition on periodontal health and on systemic health has been, and is being established. The oral microbiome, in turn, can be altered by local and systemic diseases and conditions. Gastroesophageal reflux disease (GERD), has been associated with increased ac...

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Autores principales:	Nadia Kawar, Seon Gyeong Park, Joel L. Schwartz, Nicholas Callahan, Ales Obrez, Bin Yang, Zhengjia Chen, Guy R. Adami
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1453a544f77246b9ae2b3cefbf05d62f
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spelling	oai:doaj.org-article:1453a544f77246b9ae2b3cefbf05d62f2021-12-02T15:08:21ZSalivary microbiome with gastroesophageal reflux disease and treatment10.1038/s41598-020-80170-y2045-2322https://doaj.org/article/1453a544f77246b9ae2b3cefbf05d62f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80170-yhttps://doaj.org/toc/2045-2322Abstract The effect of oral microbial composition on periodontal health and on systemic health has been, and is being established. The oral microbiome, in turn, can be altered by local and systemic diseases and conditions. Gastroesophageal reflux disease (GERD), has been associated with increased acidity in the oral cavity resulting in dental erosion, and controversially a reduced risk of periodontal disease. We hypothesized that presence of GERD was linked to a modified microbial profile in untreated GERD patients and that the use of proton pump inhibitor (PPI) drugs: potent disruptors of gut microbiome, in GERD patients might result in a salivary microbiome that is further distinct. Untreated GERD patients showed multiple differences in salivary microbiome as compared to healthy controls. Taxa found at lower levels related to the presence of GERD not treated by PPI included: Prevotella melaninogenica, Prevotella pallens, Leptotrichia, and Solobacterium moorei and thirteen others. In contrast, GERD patients chronically using PPI showed minimal differences in salivary taxa compared to healthy controls not using PPI.Nadia KawarSeon Gyeong ParkJoel L. SchwartzNicholas CallahanAles ObrezBin YangZhengjia ChenGuy R. AdamiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nadia Kawar Seon Gyeong Park Joel L. Schwartz Nicholas Callahan Ales Obrez Bin Yang Zhengjia Chen Guy R. Adami Salivary microbiome with gastroesophageal reflux disease and treatment
description	Abstract The effect of oral microbial composition on periodontal health and on systemic health has been, and is being established. The oral microbiome, in turn, can be altered by local and systemic diseases and conditions. Gastroesophageal reflux disease (GERD), has been associated with increased acidity in the oral cavity resulting in dental erosion, and controversially a reduced risk of periodontal disease. We hypothesized that presence of GERD was linked to a modified microbial profile in untreated GERD patients and that the use of proton pump inhibitor (PPI) drugs: potent disruptors of gut microbiome, in GERD patients might result in a salivary microbiome that is further distinct. Untreated GERD patients showed multiple differences in salivary microbiome as compared to healthy controls. Taxa found at lower levels related to the presence of GERD not treated by PPI included: Prevotella melaninogenica, Prevotella pallens, Leptotrichia, and Solobacterium moorei and thirteen others. In contrast, GERD patients chronically using PPI showed minimal differences in salivary taxa compared to healthy controls not using PPI.
format	article
author	Nadia Kawar Seon Gyeong Park Joel L. Schwartz Nicholas Callahan Ales Obrez Bin Yang Zhengjia Chen Guy R. Adami
author_facet	Nadia Kawar Seon Gyeong Park Joel L. Schwartz Nicholas Callahan Ales Obrez Bin Yang Zhengjia Chen Guy R. Adami
author_sort	Nadia Kawar
title	Salivary microbiome with gastroesophageal reflux disease and treatment
title_short	Salivary microbiome with gastroesophageal reflux disease and treatment
title_full	Salivary microbiome with gastroesophageal reflux disease and treatment
title_fullStr	Salivary microbiome with gastroesophageal reflux disease and treatment
title_full_unstemmed	Salivary microbiome with gastroesophageal reflux disease and treatment
title_sort	salivary microbiome with gastroesophageal reflux disease and treatment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1453a544f77246b9ae2b3cefbf05d62f
work_keys_str_mv	AT nadiakawar salivarymicrobiomewithgastroesophagealrefluxdiseaseandtreatment AT seongyeongpark salivarymicrobiomewithgastroesophagealrefluxdiseaseandtreatment AT joellschwartz salivarymicrobiomewithgastroesophagealrefluxdiseaseandtreatment AT nicholascallahan salivarymicrobiomewithgastroesophagealrefluxdiseaseandtreatment AT alesobrez salivarymicrobiomewithgastroesophagealrefluxdiseaseandtreatment AT binyang salivarymicrobiomewithgastroesophagealrefluxdiseaseandtreatment AT zhengjiachen salivarymicrobiomewithgastroesophagealrefluxdiseaseandtreatment AT guyradami salivarymicrobiomewithgastroesophagealrefluxdiseaseandtreatment
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Salivary microbiome with gastroesophageal reflux disease and treatment

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