Previous exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques.
Concerns have arisen that pre-existing immunity to dengue virus (DENV) could enhance Zika virus (ZIKV) disease, due to the homology between ZIKV and DENV and the observation of antibody-dependent enhancement (ADE) among DENV serotypes. To date, no study has examined the impact of pre-existing DENV i...
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Public Library of Science (PLoS)
2021
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oai:doaj.org-article:1455c754d9084b968c3c722d37483da72021-11-25T06:33:25ZPrevious exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques.1935-27271935-273510.1371/journal.pntd.0009641https://doaj.org/article/1455c754d9084b968c3c722d37483da72021-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009641https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735Concerns have arisen that pre-existing immunity to dengue virus (DENV) could enhance Zika virus (ZIKV) disease, due to the homology between ZIKV and DENV and the observation of antibody-dependent enhancement (ADE) among DENV serotypes. To date, no study has examined the impact of pre-existing DENV immunity on ZIKV pathogenesis during pregnancy in a translational non-human primate model. Here we show that macaques with a prior DENV-2 exposure had a higher burden of ZIKV vRNA in maternal-fetal interface tissues as compared to DENV-naive macaques. However, pre-existing DENV immunity had no detectable impact on ZIKV replication kinetics in maternal plasma, and all pregnancies progressed to term without adverse outcomes or gross fetal abnormalities detectable at delivery. Understanding the risks of ADE to pregnant women worldwide is critical as vaccines against DENV and ZIKV are developed and licensed and as DENV and ZIKV continue to circulate.Chelsea M CrooksAndrea M WeilerSierra L RybarczykMason I BlissAnna S JaegerMegan E MurphyHeather A SimmonsAndres MejiaMichael K FritschJennifer M HayesJens C EickhoffAnn M MitzeyElaina RazoKatarina M BraunElizabeth A BrownKeisuke YamamotoPhoenix M ShepherdAmber PossellKara WeaverKathleen M AntonyTerry K MorganChristina M NewmanDawn M DudleyNancy Schultz-DarkenEric PetersonLeah C KatzelnickAngel BalmasedaEva HarrisDavid H O'ConnorEmma L MohrThaddeus G GolosThomas C FriedrichMatthew T AliotaPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009641 (2021) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
| spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Chelsea M Crooks Andrea M Weiler Sierra L Rybarczyk Mason I Bliss Anna S Jaeger Megan E Murphy Heather A Simmons Andres Mejia Michael K Fritsch Jennifer M Hayes Jens C Eickhoff Ann M Mitzey Elaina Razo Katarina M Braun Elizabeth A Brown Keisuke Yamamoto Phoenix M Shepherd Amber Possell Kara Weaver Kathleen M Antony Terry K Morgan Christina M Newman Dawn M Dudley Nancy Schultz-Darken Eric Peterson Leah C Katzelnick Angel Balmaseda Eva Harris David H O'Connor Emma L Mohr Thaddeus G Golos Thomas C Friedrich Matthew T Aliota Previous exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques. |
| description |
Concerns have arisen that pre-existing immunity to dengue virus (DENV) could enhance Zika virus (ZIKV) disease, due to the homology between ZIKV and DENV and the observation of antibody-dependent enhancement (ADE) among DENV serotypes. To date, no study has examined the impact of pre-existing DENV immunity on ZIKV pathogenesis during pregnancy in a translational non-human primate model. Here we show that macaques with a prior DENV-2 exposure had a higher burden of ZIKV vRNA in maternal-fetal interface tissues as compared to DENV-naive macaques. However, pre-existing DENV immunity had no detectable impact on ZIKV replication kinetics in maternal plasma, and all pregnancies progressed to term without adverse outcomes or gross fetal abnormalities detectable at delivery. Understanding the risks of ADE to pregnant women worldwide is critical as vaccines against DENV and ZIKV are developed and licensed and as DENV and ZIKV continue to circulate. |
| format |
article |
| author |
Chelsea M Crooks Andrea M Weiler Sierra L Rybarczyk Mason I Bliss Anna S Jaeger Megan E Murphy Heather A Simmons Andres Mejia Michael K Fritsch Jennifer M Hayes Jens C Eickhoff Ann M Mitzey Elaina Razo Katarina M Braun Elizabeth A Brown Keisuke Yamamoto Phoenix M Shepherd Amber Possell Kara Weaver Kathleen M Antony Terry K Morgan Christina M Newman Dawn M Dudley Nancy Schultz-Darken Eric Peterson Leah C Katzelnick Angel Balmaseda Eva Harris David H O'Connor Emma L Mohr Thaddeus G Golos Thomas C Friedrich Matthew T Aliota |
| author_facet |
Chelsea M Crooks Andrea M Weiler Sierra L Rybarczyk Mason I Bliss Anna S Jaeger Megan E Murphy Heather A Simmons Andres Mejia Michael K Fritsch Jennifer M Hayes Jens C Eickhoff Ann M Mitzey Elaina Razo Katarina M Braun Elizabeth A Brown Keisuke Yamamoto Phoenix M Shepherd Amber Possell Kara Weaver Kathleen M Antony Terry K Morgan Christina M Newman Dawn M Dudley Nancy Schultz-Darken Eric Peterson Leah C Katzelnick Angel Balmaseda Eva Harris David H O'Connor Emma L Mohr Thaddeus G Golos Thomas C Friedrich Matthew T Aliota |
| author_sort |
Chelsea M Crooks |
| title |
Previous exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques. |
| title_short |
Previous exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques. |
| title_full |
Previous exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques. |
| title_fullStr |
Previous exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques. |
| title_full_unstemmed |
Previous exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques. |
| title_sort |
previous exposure to dengue virus is associated with increased zika virus burden at the maternal-fetal interface in rhesus macaques. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/1455c754d9084b968c3c722d37483da7 |
| work_keys_str_mv |
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