Lipid Profile Variations and Their Associations with Kidney Injury in Patients with COVID-19

Background: COVID effects different people in different ways. Acute kidney injury and variations in lipid profile are frequent complications among patients hospitalized for Covid-19. Severely infected patients with Covid-19 have higher frequency of kidney injury and hypolipidemia, resulting in high...

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Autores principales:	Haji Muhammad Rashid, Muhammad Aamer Sujjad, Hiza Hassan, Mudassar khan, Jamal Khan, Mehreen Akhlaq Abbasi
Formato:	article
Lenguaje:	EN
Publicado:	Jinnah University for Women 2021
Materias:	Covid-19, Dyslipidemia, eGFR , Kidney injury, Lipid profile. Medicine R Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/145822741b114555a1a0d8de64116dca
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spelling	oai:doaj.org-article:145822741b114555a1a0d8de64116dca2021-11-25T06:47:14ZLipid Profile Variations and Their Associations with Kidney Injury in Patients with COVID-1910.37962/jbas.v12i1.3752305-87222521-8573https://doaj.org/article/145822741b114555a1a0d8de64116dca2021-07-01T00:00:00Zhttp://jbas.juw.edu.pk/index.php/JBAS/article/view/375https://doaj.org/toc/2305-8722https://doaj.org/toc/2521-8573 Background: COVID effects different people in different ways. Acute kidney injury and variations in lipid profile are frequent complications among patients hospitalized for Covid-19. Severely infected patients with Covid-19 have higher frequency of kidney injury and hypolipidemia, resulting in higher mortality rate. Objectives: The current study was designed to explore variations in lipid profile and estimated Glomerular Filtration Rate (eGFR) in Covid-19 patients, and to evaluate the association of eGFR with lipid parameters in Covid-19 patients (confirmed cases) and healthy controls. Methodology: This comparative cross sectional study was carried out at pathology lab of MACCA Diagnostic, Multan from Oct 2020 to Jan 2021. We enrolled 225 Covid-19 patients as test group and 225 healthy subjects (negative for Covid-19) as control group. Fasting blood samples of Covid-19 and control group were collected to test lipid profile and eGFR. Estimated GFR was calculated from the value of serum creatinine, age, gender and ethnicity of all participants by applying Modification of Diet in Renal Disease (MDRD) equation. Results: All parameters of lipid profile and eGFR were significantly lower in Covid-19 patients group than healthy control group, with p-value <0.0001. We found strong positive association between eGfR and serum High density lipoproteins (HDL) levels (r2= 0.57) in Covid-19 patients. Conclusion: Hypolipidemia and decreased in eGFR were observed in Covid-19 patients, and extent of kidney injury (decrease in eGfR) was positively associated with serum HDL. Haji Muhammad RashidMuhammad Aamer SujjadHiza HassanMudassar khanJamal KhanMehreen Akhlaq AbbasiJinnah University for WomenarticleCovid-19, Dyslipidemia, eGFR , Kidney injury, Lipid profile.MedicineRBiology (General)QH301-705.5ENRADS Journal of Biological Research & Applied Science, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Covid-19, Dyslipidemia, eGFR , Kidney injury, Lipid profile. Medicine R Biology (General) QH301-705.5
spellingShingle	Covid-19, Dyslipidemia, eGFR , Kidney injury, Lipid profile. Medicine R Biology (General) QH301-705.5 Haji Muhammad Rashid Muhammad Aamer Sujjad Hiza Hassan Mudassar khan Jamal Khan Mehreen Akhlaq Abbasi Lipid Profile Variations and Their Associations with Kidney Injury in Patients with COVID-19
description	Background: COVID effects different people in different ways. Acute kidney injury and variations in lipid profile are frequent complications among patients hospitalized for Covid-19. Severely infected patients with Covid-19 have higher frequency of kidney injury and hypolipidemia, resulting in higher mortality rate. Objectives: The current study was designed to explore variations in lipid profile and estimated Glomerular Filtration Rate (eGFR) in Covid-19 patients, and to evaluate the association of eGFR with lipid parameters in Covid-19 patients (confirmed cases) and healthy controls. Methodology: This comparative cross sectional study was carried out at pathology lab of MACCA Diagnostic, Multan from Oct 2020 to Jan 2021. We enrolled 225 Covid-19 patients as test group and 225 healthy subjects (negative for Covid-19) as control group. Fasting blood samples of Covid-19 and control group were collected to test lipid profile and eGFR. Estimated GFR was calculated from the value of serum creatinine, age, gender and ethnicity of all participants by applying Modification of Diet in Renal Disease (MDRD) equation. Results: All parameters of lipid profile and eGFR were significantly lower in Covid-19 patients group than healthy control group, with p-value <0.0001. We found strong positive association between eGfR and serum High density lipoproteins (HDL) levels (r2= 0.57) in Covid-19 patients. Conclusion: Hypolipidemia and decreased in eGFR were observed in Covid-19 patients, and extent of kidney injury (decrease in eGfR) was positively associated with serum HDL.
format	article
author	Haji Muhammad Rashid Muhammad Aamer Sujjad Hiza Hassan Mudassar khan Jamal Khan Mehreen Akhlaq Abbasi
author_facet	Haji Muhammad Rashid Muhammad Aamer Sujjad Hiza Hassan Mudassar khan Jamal Khan Mehreen Akhlaq Abbasi
author_sort	Haji Muhammad Rashid
title	Lipid Profile Variations and Their Associations with Kidney Injury in Patients with COVID-19
title_short	Lipid Profile Variations and Their Associations with Kidney Injury in Patients with COVID-19
title_full	Lipid Profile Variations and Their Associations with Kidney Injury in Patients with COVID-19
title_fullStr	Lipid Profile Variations and Their Associations with Kidney Injury in Patients with COVID-19
title_full_unstemmed	Lipid Profile Variations and Their Associations with Kidney Injury in Patients with COVID-19
title_sort	lipid profile variations and their associations with kidney injury in patients with covid-19
publisher	Jinnah University for Women
publishDate	2021
url	https://doaj.org/article/145822741b114555a1a0d8de64116dca
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Lipid Profile Variations and Their Associations with Kidney Injury in Patients with COVID-19

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