A genetic variant in the IL-17 promoter is functionally associated with acute graft-versus-host disease after unrelated bone marrow transplantation.

A genetic variant in the IL-17 promoter is functionally associated with acute graft-versus-host disease after unrelated bone marrow transplantation.

Interleukin IL-17 is a proinflammatory cytokine that has been implicated in the pathogenesis of various autoimmune diseases. The single nucleotide polymorphism (SNP), rs2275913, in the promoter region of the IL-17 gene is associated with susceptibility to ulcerative colitis. When we examined the imp...

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Main Authors: J Luis Espinoza, Akiyoshi Takami, Katsuya Nakata, Makoto Onizuka, Takakazu Kawase, Hideki Akiyama, Koichi Miyamura, Yasuo Morishima, Takahiro Fukuda, Yoshihisa Kodera, Shinji Nakao, Japan Marrow Donor Program
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2011
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/145826f403f048f8904f6e7d681b9802
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