Hydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib

Hydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib

Abstract Small molecules targeting the EGFR tyrosine kinase domain have been used with some success at treating patients with non-small cell lung cancer driven by activating mutations in the kinase domain. The initial class of inhibitors displaced ATP noncovalently but were rendered ineffective due...

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Autores principales: Srinivasaraghavan Kannan, Mohan R. Pradhan, Garima Tiwari, Wei-Chong Tan, Balram Chowbay, Eng Huat Tan, Daniel Shao-Weng Tan, Chandra Verma
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/145a6170f8624c79b228e5d534e4ff3b
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