Model based development of tacrolimus dosing algorithm considering CYP3A5 genotypes and mycophenolate mofetil drug interaction in stable kidney transplant recipients

Model based development of tacrolimus dosing algorithm considering CYP3A5 genotypes and mycophenolate mofetil drug interaction in stable kidney transplant recipients

Abstract This study quantifies the interaction between tacrolimus (TAC) and mycophenolate mofetil (MMF) in kidney transplant recipients. Concentrations of TAC, mycophenolic acid (MPA), and metabolites were analyzed and relevant genotypes were determined from 32 patients. A population model was devel...

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Autores principales: Jae Hyun Kim, Nayoung Han, Myeong Gyu Kim, Young Won Kim, Hayoung Jang, Hwi-Yeol Yun, Mi-Yeon Yu, In-Wha Kim, Yon Su Kim, Jung Mi Oh
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/145ab1dcf707415c97b7cd739eaf13fa
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