Three <italic toggle="yes">Toxoplasma gondii</italic> Dense Granule Proteins Are Required for Induction of Lewis Rat Macrophage Pyroptosis

ABSTRACT Upon invasion of Lewis rat macrophages, Toxoplasma rapidly induces programmed cell death (pyroptosis), which prevents Toxoplasma replication, possibly explaining the resistance of the Lewis rat to Toxoplasma. Using a chemical mutagenesis screen, we identified Toxoplasma mutants that no long...

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Auteurs principaux: Yifan Wang, Kimberly M. Cirelli, Patricio D. C. Barros, Lamba Omar Sangaré, Vincent Butty, Musa A. Hassan, Patricia Pesavento, Asli Mete, Jeroen P. J. Saeij
Format: article
Langue:EN
Publié: American Society for Microbiology 2019
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Accès en ligne:https://doaj.org/article/1462382b1c284276b4916c2eb582db60
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