Impact of Obesity and Its Associated Comorbid Conditions on COVID-19 Presentation

Osama Mehanna,1,2 Ahmad El Askary,3,4 Ebtesam Ali,5 Basem El Esawy,3,6 Tamer FathAlla,7 Amal F Gharib3,8 1Department of Medical Physiology, College of Medicine, Taif University, Taif 21944, Saudi Arabia; 2Department of Medical Physiology, Faculty of Medicine, Al-Azhar University, New Damietta, Egypt...

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Autores principales:	Mehanna O, El Askary A, Ali E, El Esawy B, FathAlla T, Gharib AF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	obesity covid-19 egyptian Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/1462dcf5237540d5b0f02f06c0487f4a
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spelling	oai:doaj.org-article:1462dcf5237540d5b0f02f06c0487f4a2021-12-02T13:53:35ZImpact of Obesity and Its Associated Comorbid Conditions on COVID-19 Presentation1178-7007https://doaj.org/article/1462dcf5237540d5b0f02f06c0487f4a2021-01-01T00:00:00Zhttps://www.dovepress.com/impact-of-obesity-and-its-associated-comorbid-conditions-on-covid-19-p-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Osama Mehanna,1,2 Ahmad El Askary,3,4 Ebtesam Ali,5 Basem El Esawy,3,6 Tamer FathAlla,7 Amal F Gharib3,8 1Department of Medical Physiology, College of Medicine, Taif University, Taif 21944, Saudi Arabia; 2Department of Medical Physiology, Faculty of Medicine, Al-Azhar University, New Damietta, Egypt; 3Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia; 4Department of Medical Biochemistry, Faculty of Medicine, Al-Azhar University, New Damietta, Egypt; 5Directorate of Health Affairs, Gharbia Governorate, Ministry of Health and Population, Cairo, Egypt; 6Department of Pathology, Faculty of Medicine, Mansoura University, Al Mansurah, Egypt; 7Department of Anaesthesia and ICU, Faculty of Medicine, Al-Azhar University, New Damietta, Egypt; 8Department of Medical Biochemistry, Faculty of Medicine, Zagazig University, Zagazig, EgyptCorrespondence: Osama Mehanna Email dr587@yahoo.comBackground: There is great variability in clinical presentation of COVID-19 worldwide. The current study evaluated the impact of obesity and its related complications on the course of COVID-19 in Egyptian patients.Methods: We included 230 COVID-19 Egyptian patients from Tanta City. According to their body-mass index (BMI), patient were divided into three groups: normal weight (BMI < 25 kg/m2), overweight (BMI > 25–< 30 kg/m2), and obese (BMI ≥ 30 kg/m2). Patients’ glycemic status, lipid profile, and serum levels of acute-phase reactants were assessed. The number of patients receiving intensive care and the number of deaths in each group were counted.Results: Mean values of random blood sugar, serum cholesterol, triglycerides, serum ferritin, erythrocyte-sedimentation rate, LDH, CRP, D-dimer levels, and blood pressure were significantly higher in obese patients (165.6, 129.5, 105, 1,873, 26, 403, 56.45, 977.16 and 142/87, respectively) than in normal-weight (97.2, 103.5, 70.4, 479, 17.4, 252, 23.2, 612.4, and 118.6/76.8, respectively) and overweight patients (111.4, 106.3, 78.13, 491.3, 19.8, 269.27, 25.42, 618.4, and 120.3/79.3, respectively). Lymphopenia was also significantly predominant in the obese group. Multivariate logistic regression analysis revealed that elevated serum triglycerides, total cholesterol, low density–lipoprotein cholesterol, blood pressure, ferritin, CRP, and low relative lymphocyte count were significant risk factors in obese COVID-19 patients.Conclusion: Obesity and its related complications increase the risk of presenting a more severe form of COVID-19 in Egyptian patients.Keywords: obesity, COVID-19, EgyptianMehanna OEl Askary AAli EEl Esawy BFathAlla TGharib AFDove Medical Pressarticleobesitycovid-19egyptianSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 409-415 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity covid-19 egyptian Specialties of internal medicine RC581-951
spellingShingle	obesity covid-19 egyptian Specialties of internal medicine RC581-951 Mehanna O El Askary A Ali E El Esawy B FathAlla T Gharib AF Impact of Obesity and Its Associated Comorbid Conditions on COVID-19 Presentation
description	Osama Mehanna,1,2 Ahmad El Askary,3,4 Ebtesam Ali,5 Basem El Esawy,3,6 Tamer FathAlla,7 Amal F Gharib3,8 1Department of Medical Physiology, College of Medicine, Taif University, Taif 21944, Saudi Arabia; 2Department of Medical Physiology, Faculty of Medicine, Al-Azhar University, New Damietta, Egypt; 3Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia; 4Department of Medical Biochemistry, Faculty of Medicine, Al-Azhar University, New Damietta, Egypt; 5Directorate of Health Affairs, Gharbia Governorate, Ministry of Health and Population, Cairo, Egypt; 6Department of Pathology, Faculty of Medicine, Mansoura University, Al Mansurah, Egypt; 7Department of Anaesthesia and ICU, Faculty of Medicine, Al-Azhar University, New Damietta, Egypt; 8Department of Medical Biochemistry, Faculty of Medicine, Zagazig University, Zagazig, EgyptCorrespondence: Osama Mehanna Email dr587@yahoo.comBackground: There is great variability in clinical presentation of COVID-19 worldwide. The current study evaluated the impact of obesity and its related complications on the course of COVID-19 in Egyptian patients.Methods: We included 230 COVID-19 Egyptian patients from Tanta City. According to their body-mass index (BMI), patient were divided into three groups: normal weight (BMI < 25 kg/m2), overweight (BMI > 25–< 30 kg/m2), and obese (BMI ≥ 30 kg/m2). Patients’ glycemic status, lipid profile, and serum levels of acute-phase reactants were assessed. The number of patients receiving intensive care and the number of deaths in each group were counted.Results: Mean values of random blood sugar, serum cholesterol, triglycerides, serum ferritin, erythrocyte-sedimentation rate, LDH, CRP, D-dimer levels, and blood pressure were significantly higher in obese patients (165.6, 129.5, 105, 1,873, 26, 403, 56.45, 977.16 and 142/87, respectively) than in normal-weight (97.2, 103.5, 70.4, 479, 17.4, 252, 23.2, 612.4, and 118.6/76.8, respectively) and overweight patients (111.4, 106.3, 78.13, 491.3, 19.8, 269.27, 25.42, 618.4, and 120.3/79.3, respectively). Lymphopenia was also significantly predominant in the obese group. Multivariate logistic regression analysis revealed that elevated serum triglycerides, total cholesterol, low density–lipoprotein cholesterol, blood pressure, ferritin, CRP, and low relative lymphocyte count were significant risk factors in obese COVID-19 patients.Conclusion: Obesity and its related complications increase the risk of presenting a more severe form of COVID-19 in Egyptian patients.Keywords: obesity, COVID-19, Egyptian
format	article
author	Mehanna O El Askary A Ali E El Esawy B FathAlla T Gharib AF
author_facet	Mehanna O El Askary A Ali E El Esawy B FathAlla T Gharib AF
author_sort	Mehanna O
title	Impact of Obesity and Its Associated Comorbid Conditions on COVID-19 Presentation
title_short	Impact of Obesity and Its Associated Comorbid Conditions on COVID-19 Presentation
title_full	Impact of Obesity and Its Associated Comorbid Conditions on COVID-19 Presentation
title_fullStr	Impact of Obesity and Its Associated Comorbid Conditions on COVID-19 Presentation
title_full_unstemmed	Impact of Obesity and Its Associated Comorbid Conditions on COVID-19 Presentation
title_sort	impact of obesity and its associated comorbid conditions on covid-19 presentation
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/1462dcf5237540d5b0f02f06c0487f4a
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Impact of Obesity and Its Associated Comorbid Conditions on COVID-19 Presentation

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