NK cells are negatively regulated by sCD83 in experimental autoimmune uveitis

Abstract Natural killer (NK) cells represent a subset of lymphocytes that contribute to innate immunity and have been reported to play a role in autoimmune uveitis. However, the mechanisms regulating NK cellular function in this condition remain unclear. Herein, we investigated the status of NK cell...

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Autores principales:	Wei Lin, Xuejing Man, Peng Li, Nannan Song, Yingying Yue, Bingqing Li, Yuanbin Li, Yufei Sun, Qiang Fu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/14630e424e2a4685ad964d7d9bd5acc3
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spelling	oai:doaj.org-article:14630e424e2a4685ad964d7d9bd5acc32021-12-02T11:50:57ZNK cells are negatively regulated by sCD83 in experimental autoimmune uveitis10.1038/s41598-017-13412-12045-2322https://doaj.org/article/14630e424e2a4685ad964d7d9bd5acc32017-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-13412-1https://doaj.org/toc/2045-2322Abstract Natural killer (NK) cells represent a subset of lymphocytes that contribute to innate immunity and have been reported to play a role in autoimmune uveitis. However, the mechanisms regulating NK cellular function in this condition remain unclear. Herein, we investigated the status of NK cells in experimental autoimmune uveitis (EAU). We found that the number of CD83+CD3−NK1.1+ cells was increased in the inflamed eyes and spleens of the EAU mouse model. At the recovery stage of EAU, serum concentrations of soluble CD83 (sCD83) were increased. sCD83 treatment relieved retinal tissue damage and decreased the number of infiltrating NK cells in inflamed eyes. Further analysis of the effects of sCD83 treatment in EAU revealed that it reduced: 1) the expressions of CD11b and CD83 in NK cells, 2) the percent of CD11bhighCD27lowCD3−NK1.1+ cells and 3) the secretion of granzyme B, perforin and IFN-γ in NK cells as demonstrated both in vivo and in vitro. When sCD83 treated-NK cells were transferred into EAU mice, retinal tissue damage was relieved. These results demonstrate sCD83 down-regulate NK cellular function and thus provide important, new information regarding the means for the beneficial effects of this agent in the treatment of autoimmune uveitis.Wei LinXuejing ManPeng LiNannan SongYingying YueBingqing LiYuanbin LiYufei SunQiang FuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wei Lin Xuejing Man Peng Li Nannan Song Yingying Yue Bingqing Li Yuanbin Li Yufei Sun Qiang Fu NK cells are negatively regulated by sCD83 in experimental autoimmune uveitis
description	Abstract Natural killer (NK) cells represent a subset of lymphocytes that contribute to innate immunity and have been reported to play a role in autoimmune uveitis. However, the mechanisms regulating NK cellular function in this condition remain unclear. Herein, we investigated the status of NK cells in experimental autoimmune uveitis (EAU). We found that the number of CD83+CD3−NK1.1+ cells was increased in the inflamed eyes and spleens of the EAU mouse model. At the recovery stage of EAU, serum concentrations of soluble CD83 (sCD83) were increased. sCD83 treatment relieved retinal tissue damage and decreased the number of infiltrating NK cells in inflamed eyes. Further analysis of the effects of sCD83 treatment in EAU revealed that it reduced: 1) the expressions of CD11b and CD83 in NK cells, 2) the percent of CD11bhighCD27lowCD3−NK1.1+ cells and 3) the secretion of granzyme B, perforin and IFN-γ in NK cells as demonstrated both in vivo and in vitro. When sCD83 treated-NK cells were transferred into EAU mice, retinal tissue damage was relieved. These results demonstrate sCD83 down-regulate NK cellular function and thus provide important, new information regarding the means for the beneficial effects of this agent in the treatment of autoimmune uveitis.
format	article
author	Wei Lin Xuejing Man Peng Li Nannan Song Yingying Yue Bingqing Li Yuanbin Li Yufei Sun Qiang Fu
author_facet	Wei Lin Xuejing Man Peng Li Nannan Song Yingying Yue Bingqing Li Yuanbin Li Yufei Sun Qiang Fu
author_sort	Wei Lin
title	NK cells are negatively regulated by sCD83 in experimental autoimmune uveitis
title_short	NK cells are negatively regulated by sCD83 in experimental autoimmune uveitis
title_full	NK cells are negatively regulated by sCD83 in experimental autoimmune uveitis
title_fullStr	NK cells are negatively regulated by sCD83 in experimental autoimmune uveitis
title_full_unstemmed	NK cells are negatively regulated by sCD83 in experimental autoimmune uveitis
title_sort	nk cells are negatively regulated by scd83 in experimental autoimmune uveitis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/14630e424e2a4685ad964d7d9bd5acc3
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_version_	1718395149464109056

NK cells are negatively regulated by sCD83 in experimental autoimmune uveitis

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