Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3

Pathological lymphangiogenesis is associated with various eye diseases. Here the authors show that a carbohydrate-binding protein, galectin-8, promotes pathological lymphangiogenesis in the eye by regulating the crosstalk among VEGF-C, podoplanin and integrin pathways, and thus may represent a usefu...

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Autores principales:	Wei-Sheng Chen, Zhiyi Cao, Satoshi Sugaya, Maria J. Lopez, Victor G. Sendra, Nora Laver, Hakon Leffler, Ulf J. Nilsson, Jianxin Fu, Jianhua Song, Lijun Xia, Pedram Hamrah, Noorjahan Panjwani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/14686d808c8b43c99af933249da04056
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spelling	oai:doaj.org-article:14686d808c8b43c99af933249da040562021-12-02T16:50:15ZPathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-310.1038/ncomms113022041-1723https://doaj.org/article/14686d808c8b43c99af933249da040562016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11302https://doaj.org/toc/2041-1723Pathological lymphangiogenesis is associated with various eye diseases. Here the authors show that a carbohydrate-binding protein, galectin-8, promotes pathological lymphangiogenesis in the eye by regulating the crosstalk among VEGF-C, podoplanin and integrin pathways, and thus may represent a useful therapeutic target.Wei-Sheng ChenZhiyi CaoSatoshi SugayaMaria J. LopezVictor G. SendraNora LaverHakon LefflerUlf J. NilssonJianxin FuJianhua SongLijun XiaPedram HamrahNoorjahan PanjwaniNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-19 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei-Sheng Chen Zhiyi Cao Satoshi Sugaya Maria J. Lopez Victor G. Sendra Nora Laver Hakon Leffler Ulf J. Nilsson Jianxin Fu Jianhua Song Lijun Xia Pedram Hamrah Noorjahan Panjwani Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3
description	Pathological lymphangiogenesis is associated with various eye diseases. Here the authors show that a carbohydrate-binding protein, galectin-8, promotes pathological lymphangiogenesis in the eye by regulating the crosstalk among VEGF-C, podoplanin and integrin pathways, and thus may represent a useful therapeutic target.
format	article
author	Wei-Sheng Chen Zhiyi Cao Satoshi Sugaya Maria J. Lopez Victor G. Sendra Nora Laver Hakon Leffler Ulf J. Nilsson Jianxin Fu Jianhua Song Lijun Xia Pedram Hamrah Noorjahan Panjwani
author_facet	Wei-Sheng Chen Zhiyi Cao Satoshi Sugaya Maria J. Lopez Victor G. Sendra Nora Laver Hakon Leffler Ulf J. Nilsson Jianxin Fu Jianhua Song Lijun Xia Pedram Hamrah Noorjahan Panjwani
author_sort	Wei-Sheng Chen
title	Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3
title_short	Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3
title_full	Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3
title_fullStr	Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3
title_full_unstemmed	Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3
title_sort	pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated vegfr-3
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/14686d808c8b43c99af933249da04056
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Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3

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