Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model

Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model

Oligodendrocyte damage is a key component of demyelinating diseases. Here, the authors use in vivolight and correlated electron microscopy in EAE mouse models, and find early damage occurs at the myelin sheath before spreading to the oligodendrocyte cell body.

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Autores principales: Elisa Romanelli, Doron Merkler, Aleksandra Mezydlo, Marie-Theres Weil, Martin S. Weber, Ivana Nikić, Stephanie Potz, Edgar Meinl, Florian E. H. Matznick, Mario Kreutzfeldt, Alexander Ghanem, Karl-Klaus Conzelmann, Imke Metz, Wolfgang Brück, Matthew Routh, Mikael Simons, Derron Bishop, Thomas Misgeld, Martin Kerschensteiner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/146e33120f3a4d8680a6a094ee4905f3
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spelling oai:doaj.org-article:146e33120f3a4d8680a6a094ee4905f32021-12-02T16:49:27ZMyelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model10.1038/ncomms132752041-1723https://doaj.org/article/146e33120f3a4d8680a6a094ee4905f32016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13275https://doaj.org/toc/2041-1723Oligodendrocyte damage is a key component of demyelinating diseases. Here, the authors use in vivolight and correlated electron microscopy in EAE mouse models, and find early damage occurs at the myelin sheath before spreading to the oligodendrocyte cell body.Elisa RomanelliDoron MerklerAleksandra MezydloMarie-Theres WeilMartin S. WeberIvana NikićStephanie PotzEdgar MeinlFlorian E. H. MatznickMario KreutzfeldtAlexander GhanemKarl-Klaus ConzelmannImke MetzWolfgang BrückMatthew RouthMikael SimonsDerron BishopThomas MisgeldMartin KerschensteinerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Elisa Romanelli
Doron Merkler
Aleksandra Mezydlo
Marie-Theres Weil
Martin S. Weber
Ivana Nikić
Stephanie Potz
Edgar Meinl
Florian E. H. Matznick
Mario Kreutzfeldt
Alexander Ghanem
Karl-Klaus Conzelmann
Imke Metz
Wolfgang Brück
Matthew Routh
Mikael Simons
Derron Bishop
Thomas Misgeld
Martin Kerschensteiner
Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model
description Oligodendrocyte damage is a key component of demyelinating diseases. Here, the authors use in vivolight and correlated electron microscopy in EAE mouse models, and find early damage occurs at the myelin sheath before spreading to the oligodendrocyte cell body.
format article
author Elisa Romanelli
Doron Merkler
Aleksandra Mezydlo
Marie-Theres Weil
Martin S. Weber
Ivana Nikić
Stephanie Potz
Edgar Meinl
Florian E. H. Matznick
Mario Kreutzfeldt
Alexander Ghanem
Karl-Klaus Conzelmann
Imke Metz
Wolfgang Brück
Matthew Routh
Mikael Simons
Derron Bishop
Thomas Misgeld
Martin Kerschensteiner
author_facet Elisa Romanelli
Doron Merkler
Aleksandra Mezydlo
Marie-Theres Weil
Martin S. Weber
Ivana Nikić
Stephanie Potz
Edgar Meinl
Florian E. H. Matznick
Mario Kreutzfeldt
Alexander Ghanem
Karl-Klaus Conzelmann
Imke Metz
Wolfgang Brück
Matthew Routh
Mikael Simons
Derron Bishop
Thomas Misgeld
Martin Kerschensteiner
author_sort Elisa Romanelli
title Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model
title_short Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model
title_full Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model
title_fullStr Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model
title_full_unstemmed Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model
title_sort myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/146e33120f3a4d8680a6a094ee4905f3
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