Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction

How is acetyl-CoA produced in the context of the endogenous, eukaryotic pyruvate dehydrogenase complex metabolon? Here the authors dissect the embedded transacetylase reaction through biochemical, cryo-EM, HADDOCKing and molecular dynamics methods.

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Autores principales:	Christian Tüting, Fotis L. Kyrilis, Johannes Müller, Marija Sorokina, Ioannis Skalidis, Farzad Hamdi, Yashar Sadian, Panagiotis L. Kastritis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/146e4ee18ab64e4d98dd27f853aa29f7
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spelling	oai:doaj.org-article:146e4ee18ab64e4d98dd27f853aa29f72021-11-28T12:35:14ZCryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction10.1038/s41467-021-27287-42041-1723https://doaj.org/article/146e4ee18ab64e4d98dd27f853aa29f72021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27287-4https://doaj.org/toc/2041-1723How is acetyl-CoA produced in the context of the endogenous, eukaryotic pyruvate dehydrogenase complex metabolon? Here the authors dissect the embedded transacetylase reaction through biochemical, cryo-EM, HADDOCKing and molecular dynamics methods.Christian TütingFotis L. KyrilisJohannes MüllerMarija SorokinaIoannis SkalidisFarzad HamdiYashar SadianPanagiotis L. KastritisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christian Tüting Fotis L. Kyrilis Johannes Müller Marija Sorokina Ioannis Skalidis Farzad Hamdi Yashar Sadian Panagiotis L. Kastritis Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction
description	How is acetyl-CoA produced in the context of the endogenous, eukaryotic pyruvate dehydrogenase complex metabolon? Here the authors dissect the embedded transacetylase reaction through biochemical, cryo-EM, HADDOCKing and molecular dynamics methods.
format	article
author	Christian Tüting Fotis L. Kyrilis Johannes Müller Marija Sorokina Ioannis Skalidis Farzad Hamdi Yashar Sadian Panagiotis L. Kastritis
author_facet	Christian Tüting Fotis L. Kyrilis Johannes Müller Marija Sorokina Ioannis Skalidis Farzad Hamdi Yashar Sadian Panagiotis L. Kastritis
author_sort	Christian Tüting
title	Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction
title_short	Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction
title_full	Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction
title_fullStr	Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction
title_full_unstemmed	Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction
title_sort	cryo-em snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/146e4ee18ab64e4d98dd27f853aa29f7
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Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction

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