Histological Effect Of Coq10 On Liver And Buccal Mucosa In Mice

The goal of the present study is to evaluate the histological effect of Coenzyme Q10 (CoQ10) in the liver and buccal mucosa in mice. After acclimatization to the laboratory conditions, Twenty-four mice were randomly assigned to three experimental groups and housed as eight animals/cage, and each gro...

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Autores principales:	Ghasaq A. Dawood, Ghada A. Taqa, Manar M. Alnema
Formato:	article
Lenguaje:	EN
Publicado:	Egyptian Society for Animal Management 2020
Materias:	buccal mucosa coenzyme q10 histology liver mice Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
Acceso en línea:	https://dx.doi.org/10.21608/javs.2020.85543 https://doaj.org/article/146eff4c4a434e5aac7fa3d1761c0013
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spelling	oai:doaj.org-article:146eff4c4a434e5aac7fa3d1761c00132021-12-02T13:24:01ZHistological Effect Of Coq10 On Liver And Buccal Mucosa In Micehttps://dx.doi.org/10.21608/javs.2020.855431687-40722090-3308https://doaj.org/article/146eff4c4a434e5aac7fa3d1761c00132020-04-01T00:00:00Zhttps://javs.journals.ekb.eg/article_85543.htmlhttps://doaj.org/toc/1687-4072https://doaj.org/toc/2090-3308The goal of the present study is to evaluate the histological effect of Coenzyme Q10 (CoQ10) in the liver and buccal mucosa in mice. After acclimatization to the laboratory conditions, Twenty-four mice were randomly assigned to three experimental groups and housed as eight animals/cage, and each group was treated as follows: Group A: this served as a control group and was given daily olive oil orally. Group B and C were given once daily CoQ10 in dose (100mg /kg) and (200mg/kg) respectively. All groups were treated for 15 days and at the last of the experiment, all animals of each group were sacrificed and liver in addition to buccal mucosa was excised and placed in 10% buffered formalin for histological examination. In CoQ10 treated groups a normal histological structure similar to control group in liver and buccal mucosa sections were noticed at the CoQ10 (100mg/kg) group while mild histological changes were noticed at the CoQ10 (200mg/kg) group included slightly congested portal vein and sinusoids, mild centric lobular vacuolar swelling in the hepatic lobule and buccal mucosa sections showed normal structure as control group. CoQ10 at a dose (100mg/kg) not produce any histological changes in the liver and buccal mucosa in mice but when increasing the dose to (200mg/kg) produce mild histological changes in liver but not in the buccal mucosa.Ghasaq A. DawoodGhada A. TaqaManar M. AlnemaEgyptian Society for Animal Managementarticlebuccal mucosacoenzyme q10histologylivermiceZoologyQL1-991Veterinary medicineSF600-1100Animal biochemistryQP501-801ENJournal of Applied Veterinary Sciences, Vol 5, Iss 2, Pp 1-5 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	buccal mucosa coenzyme q10 histology liver mice Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
spellingShingle	buccal mucosa coenzyme q10 histology liver mice Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801 Ghasaq A. Dawood Ghada A. Taqa Manar M. Alnema Histological Effect Of Coq10 On Liver And Buccal Mucosa In Mice
description	The goal of the present study is to evaluate the histological effect of Coenzyme Q10 (CoQ10) in the liver and buccal mucosa in mice. After acclimatization to the laboratory conditions, Twenty-four mice were randomly assigned to three experimental groups and housed as eight animals/cage, and each group was treated as follows: Group A: this served as a control group and was given daily olive oil orally. Group B and C were given once daily CoQ10 in dose (100mg /kg) and (200mg/kg) respectively. All groups were treated for 15 days and at the last of the experiment, all animals of each group were sacrificed and liver in addition to buccal mucosa was excised and placed in 10% buffered formalin for histological examination. In CoQ10 treated groups a normal histological structure similar to control group in liver and buccal mucosa sections were noticed at the CoQ10 (100mg/kg) group while mild histological changes were noticed at the CoQ10 (200mg/kg) group included slightly congested portal vein and sinusoids, mild centric lobular vacuolar swelling in the hepatic lobule and buccal mucosa sections showed normal structure as control group. CoQ10 at a dose (100mg/kg) not produce any histological changes in the liver and buccal mucosa in mice but when increasing the dose to (200mg/kg) produce mild histological changes in liver but not in the buccal mucosa.
format	article
author	Ghasaq A. Dawood Ghada A. Taqa Manar M. Alnema
author_facet	Ghasaq A. Dawood Ghada A. Taqa Manar M. Alnema
author_sort	Ghasaq A. Dawood
title	Histological Effect Of Coq10 On Liver And Buccal Mucosa In Mice
title_short	Histological Effect Of Coq10 On Liver And Buccal Mucosa In Mice
title_full	Histological Effect Of Coq10 On Liver And Buccal Mucosa In Mice
title_fullStr	Histological Effect Of Coq10 On Liver And Buccal Mucosa In Mice
title_full_unstemmed	Histological Effect Of Coq10 On Liver And Buccal Mucosa In Mice
title_sort	histological effect of coq10 on liver and buccal mucosa in mice
publisher	Egyptian Society for Animal Management
publishDate	2020
url	https://dx.doi.org/10.21608/javs.2020.85543 https://doaj.org/article/146eff4c4a434e5aac7fa3d1761c0013
work_keys_str_mv	AT ghasaqadawood histologicaleffectofcoq10onliverandbuccalmucosainmice AT ghadaataqa histologicaleffectofcoq10onliverandbuccalmucosainmice AT manarmalnema histologicaleffectofcoq10onliverandbuccalmucosainmice
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Histological Effect Of Coq10 On Liver And Buccal Mucosa In Mice

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