The Influence of Size and Chemical Composition of Silver and Gold Nanoparticles on in vivo Toxicity with Potential Applications to Central Nervous System Diseases
Daniela F Báez,1– 3,* Eduardo Gallardo-Toledo,1,2,* María Paz Oyarzún,1,2 Eyleen Araya,2,4 Marcelo J Kogan1,2 1Department of Pharmacological and Toxicological Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile;...
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Dove Medical Press
2021
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oai:doaj.org-article:14710d095daa46948785ab8244e7a3922021-12-02T14:40:12ZThe Influence of Size and Chemical Composition of Silver and Gold Nanoparticles on in vivo Toxicity with Potential Applications to Central Nervous System Diseases1178-2013https://doaj.org/article/14710d095daa46948785ab8244e7a3922021-03-01T00:00:00Zhttps://www.dovepress.com/the-influence-of-size-and-chemical-composition-of-silver-and-gold-nano-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Daniela F Báez,1– 3,* Eduardo Gallardo-Toledo,1,2,* María Paz Oyarzún,1,2 Eyleen Araya,2,4 Marcelo J Kogan1,2 1Department of Pharmacological and Toxicological Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile; 2Advanced Center for Chronic Diseases (ACCDIS), Santiago, Chile; 3Redox Process Research Center, CIPRex, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile; 4Departamento de Ciencias Quimicas, Facultad de Ciencias Exactas, Universidad Andres Bello, Santiago, Chile*These authors contributed equally to this workCorrespondence: Eyleen ArayaDepartamento de Ciencias Quimicas, Facultad de Ciencias Exactas, Universidad Andres Bello, Santiago, 8370035, ChileEmail eyleen.araya@unab.clMarcelo J KoganDepartamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, 8380494, ChileEmail mkogan@ciq.uchile.clAbstract: The physicochemical and optical properties of silver nanoparticles (SNPs) and gold nanoparticles (GNPs) have allowed them to be employed for various biomedical applications, including delivery, therapy, imaging, and as theranostic agents. However, since they are foreign body systems, they are usually redistributed and accumulated in some vital organs, which can produce toxic effects; therefore, this a crucial issue that should be considered for potential clinical trials. This review aimed to summarize the reports from the past ten years that have used SNPs and GNPs for in vivo studies on the diagnosis and treatment of brain diseases and those related to the central nervous system, emphasizing their toxicity as a crucial topic address. The article focuses on the effect of the nanoparticle´s size and chemical composition as relevant parameters for in vivo toxicity. At the beginning of this review, the general toxicity and distribution studies are discussed separately for SNPs and GNPs. Subsequently, this manuscript analyzes the principal applications of both kinds of nanoparticles for glioma, neurodegenerative, and other brain diseases, and discusses the advances in clinical trials. Finally, we analyze research prospects towards clinical applications for both types of metallic nanoparticles.Keywords: silver nanoparticles, gold nanoparticles, brain diseases, central nervous system, toxicity, in vivo applicationsBáez DFGallardo-Toledo EOyarzún MPAraya EKogan MJDove Medical Pressarticlesilver nanoparticlesgold nanoparticlesbrain diseasescentral nervous systemtoxicityin-vivo applications.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 2187-2201 (2021) |
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silver nanoparticles gold nanoparticles brain diseases central nervous system toxicity in-vivo applications. Medicine (General) R5-920 |
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silver nanoparticles gold nanoparticles brain diseases central nervous system toxicity in-vivo applications. Medicine (General) R5-920 Báez DF Gallardo-Toledo E Oyarzún MP Araya E Kogan MJ The Influence of Size and Chemical Composition of Silver and Gold Nanoparticles on in vivo Toxicity with Potential Applications to Central Nervous System Diseases |
| description |
Daniela F Báez,1– 3,* Eduardo Gallardo-Toledo,1,2,* María Paz Oyarzún,1,2 Eyleen Araya,2,4 Marcelo J Kogan1,2 1Department of Pharmacological and Toxicological Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile; 2Advanced Center for Chronic Diseases (ACCDIS), Santiago, Chile; 3Redox Process Research Center, CIPRex, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile; 4Departamento de Ciencias Quimicas, Facultad de Ciencias Exactas, Universidad Andres Bello, Santiago, Chile*These authors contributed equally to this workCorrespondence: Eyleen ArayaDepartamento de Ciencias Quimicas, Facultad de Ciencias Exactas, Universidad Andres Bello, Santiago, 8370035, ChileEmail eyleen.araya@unab.clMarcelo J KoganDepartamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, 8380494, ChileEmail mkogan@ciq.uchile.clAbstract: The physicochemical and optical properties of silver nanoparticles (SNPs) and gold nanoparticles (GNPs) have allowed them to be employed for various biomedical applications, including delivery, therapy, imaging, and as theranostic agents. However, since they are foreign body systems, they are usually redistributed and accumulated in some vital organs, which can produce toxic effects; therefore, this a crucial issue that should be considered for potential clinical trials. This review aimed to summarize the reports from the past ten years that have used SNPs and GNPs for in vivo studies on the diagnosis and treatment of brain diseases and those related to the central nervous system, emphasizing their toxicity as a crucial topic address. The article focuses on the effect of the nanoparticle´s size and chemical composition as relevant parameters for in vivo toxicity. At the beginning of this review, the general toxicity and distribution studies are discussed separately for SNPs and GNPs. Subsequently, this manuscript analyzes the principal applications of both kinds of nanoparticles for glioma, neurodegenerative, and other brain diseases, and discusses the advances in clinical trials. Finally, we analyze research prospects towards clinical applications for both types of metallic nanoparticles.Keywords: silver nanoparticles, gold nanoparticles, brain diseases, central nervous system, toxicity, in vivo applications |
| format |
article |
| author |
Báez DF Gallardo-Toledo E Oyarzún MP Araya E Kogan MJ |
| author_facet |
Báez DF Gallardo-Toledo E Oyarzún MP Araya E Kogan MJ |
| author_sort |
Báez DF |
| title |
The Influence of Size and Chemical Composition of Silver and Gold Nanoparticles on in vivo Toxicity with Potential Applications to Central Nervous System Diseases |
| title_short |
The Influence of Size and Chemical Composition of Silver and Gold Nanoparticles on in vivo Toxicity with Potential Applications to Central Nervous System Diseases |
| title_full |
The Influence of Size and Chemical Composition of Silver and Gold Nanoparticles on in vivo Toxicity with Potential Applications to Central Nervous System Diseases |
| title_fullStr |
The Influence of Size and Chemical Composition of Silver and Gold Nanoparticles on in vivo Toxicity with Potential Applications to Central Nervous System Diseases |
| title_full_unstemmed |
The Influence of Size and Chemical Composition of Silver and Gold Nanoparticles on in vivo Toxicity with Potential Applications to Central Nervous System Diseases |
| title_sort |
influence of size and chemical composition of silver and gold nanoparticles on in vivo toxicity with potential applications to central nervous system diseases |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/14710d095daa46948785ab8244e7a392 |
| work_keys_str_mv |
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