Artificially decreasing cortical tension generates aneuploidy in mouse oocytes

The developmental potential of human and murine oocytes is predicted by their mechanical properties. Here the authors show that artificial reduction of cortex tension produces aneuploid mouse oocytes and speculate that this may contribute to the high aneuploidy rate typical of female meiosis.

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Autores principales:	Isma Bennabi, Flora Crozet, Elvira Nikalayevich, Agathe Chaigne, Gaëlle Letort, Marion Manil-Ségalen, Clément Campillo, Clotilde Cadart, Alice Othmani, Rafaele Attia, Auguste Genovesio, Marie-Hélène Verlhac, Marie-Emilie Terret
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/147621511e274dd9a875526215004355
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spelling	oai:doaj.org-article:147621511e274dd9a8755262150043552021-12-02T15:39:18ZArtificially decreasing cortical tension generates aneuploidy in mouse oocytes10.1038/s41467-020-15470-y2041-1723https://doaj.org/article/147621511e274dd9a8755262150043552020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15470-yhttps://doaj.org/toc/2041-1723The developmental potential of human and murine oocytes is predicted by their mechanical properties. Here the authors show that artificial reduction of cortex tension produces aneuploid mouse oocytes and speculate that this may contribute to the high aneuploidy rate typical of female meiosis.Isma BennabiFlora CrozetElvira NikalayevichAgathe ChaigneGaëlle LetortMarion Manil-SégalenClément CampilloClotilde CadartAlice OthmaniRafaele AttiaAuguste GenovesioMarie-Hélène VerlhacMarie-Emilie TerretNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Isma Bennabi Flora Crozet Elvira Nikalayevich Agathe Chaigne Gaëlle Letort Marion Manil-Ségalen Clément Campillo Clotilde Cadart Alice Othmani Rafaele Attia Auguste Genovesio Marie-Hélène Verlhac Marie-Emilie Terret Artificially decreasing cortical tension generates aneuploidy in mouse oocytes
description	The developmental potential of human and murine oocytes is predicted by their mechanical properties. Here the authors show that artificial reduction of cortex tension produces aneuploid mouse oocytes and speculate that this may contribute to the high aneuploidy rate typical of female meiosis.
format	article
author	Isma Bennabi Flora Crozet Elvira Nikalayevich Agathe Chaigne Gaëlle Letort Marion Manil-Ségalen Clément Campillo Clotilde Cadart Alice Othmani Rafaele Attia Auguste Genovesio Marie-Hélène Verlhac Marie-Emilie Terret
author_facet	Isma Bennabi Flora Crozet Elvira Nikalayevich Agathe Chaigne Gaëlle Letort Marion Manil-Ségalen Clément Campillo Clotilde Cadart Alice Othmani Rafaele Attia Auguste Genovesio Marie-Hélène Verlhac Marie-Emilie Terret
author_sort	Isma Bennabi
title	Artificially decreasing cortical tension generates aneuploidy in mouse oocytes
title_short	Artificially decreasing cortical tension generates aneuploidy in mouse oocytes
title_full	Artificially decreasing cortical tension generates aneuploidy in mouse oocytes
title_fullStr	Artificially decreasing cortical tension generates aneuploidy in mouse oocytes
title_full_unstemmed	Artificially decreasing cortical tension generates aneuploidy in mouse oocytes
title_sort	artificially decreasing cortical tension generates aneuploidy in mouse oocytes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/147621511e274dd9a875526215004355
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Artificially decreasing cortical tension generates aneuploidy in mouse oocytes

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