A general strategy for C(sp3)–H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor

When carbon-based units are functionalized in photoredox catalysis, electrophilic coupling partners are often used, such that the polarities of the two fragments are appropriately matched. Here the authors show a generalized methodology to instead use nucleophilic coupling partners, which are cheape...

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Autores principales:	Isabelle Nathalie-Marie Leibler, Makeda A. Tekle-Smith, Abigail G. Doyle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/14785e67fb6e4df39d7bb7b889aac3d0
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spelling	oai:doaj.org-article:14785e67fb6e4df39d7bb7b889aac3d02021-12-05T12:21:39ZA general strategy for C(sp3)–H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor10.1038/s41467-021-27165-z2041-1723https://doaj.org/article/14785e67fb6e4df39d7bb7b889aac3d02021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27165-zhttps://doaj.org/toc/2041-1723When carbon-based units are functionalized in photoredox catalysis, electrophilic coupling partners are often used, such that the polarities of the two fragments are appropriately matched. Here the authors show a generalized methodology to instead use nucleophilic coupling partners, which are cheaper and often simpler, via successive hydrogen atom transfer and oxidative radical-polar crossover.Isabelle Nathalie-Marie LeiblerMakeda A. Tekle-SmithAbigail G. DoyleNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Isabelle Nathalie-Marie Leibler Makeda A. Tekle-Smith Abigail G. Doyle A general strategy for C(sp3)–H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor
description	When carbon-based units are functionalized in photoredox catalysis, electrophilic coupling partners are often used, such that the polarities of the two fragments are appropriately matched. Here the authors show a generalized methodology to instead use nucleophilic coupling partners, which are cheaper and often simpler, via successive hydrogen atom transfer and oxidative radical-polar crossover.
format	article
author	Isabelle Nathalie-Marie Leibler Makeda A. Tekle-Smith Abigail G. Doyle
author_facet	Isabelle Nathalie-Marie Leibler Makeda A. Tekle-Smith Abigail G. Doyle
author_sort	Isabelle Nathalie-Marie Leibler
title	A general strategy for C(sp3)–H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor
title_short	A general strategy for C(sp3)–H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor
title_full	A general strategy for C(sp3)–H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor
title_fullStr	A general strategy for C(sp3)–H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor
title_full_unstemmed	A general strategy for C(sp3)–H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor
title_sort	general strategy for c(sp3)–h functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/14785e67fb6e4df39d7bb7b889aac3d0
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A general strategy for C(sp3)–H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor

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