Functional balance between the hemagglutinin and neuraminidase of influenza A(H1N1)pdm09 HA D222 variants.

Functional balance between the hemagglutinin and neuraminidase of influenza A(H1N1)pdm09 HA D222 variants.

D222G/N substitutions in A(H1N1)pdm09 hemagglutinin may be associated with increased binding of viruses causing low respiratory tract infections and human pathogenesis. We assessed the impact of such substitutions on the balance between hemagglutinin binding and neuraminidase cleavage, viral growth...

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Autores principales: Jean-Sébastien Casalegno, Olivier Ferraris, Vanessa Escuret, Maude Bouscambert, Corinne Bergeron, Laetitia Linès, Thierry Excoffier, Martine Valette, Emilie Frobert, Sylvie Pillet, Bruno Pozzetto, Bruno Lina, Michèle Ottmann
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/147a30bbfb6e403eaf9a140e65869f9e
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