First report on antibiotic resistance and antimicrobial activity of bacterial isolates from 13,000-year old cave ice core

Abstract Despite the unique physiology and metabolic pathways of microbiomes from cold environments providing key evolutionary insights and promising leads for discovering new bioactive compounds, cultivable bacteria entrapped in perennial ice from caves remained a largely unexplored life system. In...

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Autores principales:	Victoria I. Paun, Paris Lavin, Mariana C. Chifiriuc, Cristina Purcarea
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/147a919157774f43b47a86db61d704c5
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spelling	oai:doaj.org-article:147a919157774f43b47a86db61d704c52021-12-02T14:12:40ZFirst report on antibiotic resistance and antimicrobial activity of bacterial isolates from 13,000-year old cave ice core10.1038/s41598-020-79754-52045-2322https://doaj.org/article/147a919157774f43b47a86db61d704c52021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79754-5https://doaj.org/toc/2045-2322Abstract Despite the unique physiology and metabolic pathways of microbiomes from cold environments providing key evolutionary insights and promising leads for discovering new bioactive compounds, cultivable bacteria entrapped in perennial ice from caves remained a largely unexplored life system. In this context, we obtained and characterized bacterial strains from 13,000-years old ice core of Scarisoara Ice Cave, providing first isolates from perennial ice accumulated in caves since Late Glacial, and first culture-based evidences of bacterial resistome and antimicrobial compounds production. The 68 bacterial isolates belonged to 4 phyla, 34 genera and 56 species, with 17 strains representing putative new taxa. The Gram-negative cave bacteria (Proteobacteria and Bacteroidetes) were more resistant to the great majority of antibiotic classes than the Gram-positive ones (Actinobacteria, Firmicutes). More than 50% of the strains exhibited high resistance to 17 classes of antibiotics. Some of the isolates inhibited the growth of clinically important Gram-positive and Gram-negative resistant strains and revealed metabolic features with applicative potential. The current report on bacterial strains from millennia-old cave ice revealed promising candidates for studying the evolution of environmental resistome and for obtaining new active biomolecules for fighting the antibiotics crisis, and valuable cold-active biocatalysts.Victoria I. PaunParis LavinMariana C. ChifiriucCristina PurcareaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Victoria I. Paun Paris Lavin Mariana C. Chifiriuc Cristina Purcarea First report on antibiotic resistance and antimicrobial activity of bacterial isolates from 13,000-year old cave ice core
description	Abstract Despite the unique physiology and metabolic pathways of microbiomes from cold environments providing key evolutionary insights and promising leads for discovering new bioactive compounds, cultivable bacteria entrapped in perennial ice from caves remained a largely unexplored life system. In this context, we obtained and characterized bacterial strains from 13,000-years old ice core of Scarisoara Ice Cave, providing first isolates from perennial ice accumulated in caves since Late Glacial, and first culture-based evidences of bacterial resistome and antimicrobial compounds production. The 68 bacterial isolates belonged to 4 phyla, 34 genera and 56 species, with 17 strains representing putative new taxa. The Gram-negative cave bacteria (Proteobacteria and Bacteroidetes) were more resistant to the great majority of antibiotic classes than the Gram-positive ones (Actinobacteria, Firmicutes). More than 50% of the strains exhibited high resistance to 17 classes of antibiotics. Some of the isolates inhibited the growth of clinically important Gram-positive and Gram-negative resistant strains and revealed metabolic features with applicative potential. The current report on bacterial strains from millennia-old cave ice revealed promising candidates for studying the evolution of environmental resistome and for obtaining new active biomolecules for fighting the antibiotics crisis, and valuable cold-active biocatalysts.
format	article
author	Victoria I. Paun Paris Lavin Mariana C. Chifiriuc Cristina Purcarea
author_facet	Victoria I. Paun Paris Lavin Mariana C. Chifiriuc Cristina Purcarea
author_sort	Victoria I. Paun
title	First report on antibiotic resistance and antimicrobial activity of bacterial isolates from 13,000-year old cave ice core
title_short	First report on antibiotic resistance and antimicrobial activity of bacterial isolates from 13,000-year old cave ice core
title_full	First report on antibiotic resistance and antimicrobial activity of bacterial isolates from 13,000-year old cave ice core
title_fullStr	First report on antibiotic resistance and antimicrobial activity of bacterial isolates from 13,000-year old cave ice core
title_full_unstemmed	First report on antibiotic resistance and antimicrobial activity of bacterial isolates from 13,000-year old cave ice core
title_sort	first report on antibiotic resistance and antimicrobial activity of bacterial isolates from 13,000-year old cave ice core
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/147a919157774f43b47a86db61d704c5
work_keys_str_mv	AT victoriaipaun firstreportonantibioticresistanceandantimicrobialactivityofbacterialisolatesfrom13000yearoldcaveicecore AT parislavin firstreportonantibioticresistanceandantimicrobialactivityofbacterialisolatesfrom13000yearoldcaveicecore AT marianacchifiriuc firstreportonantibioticresistanceandantimicrobialactivityofbacterialisolatesfrom13000yearoldcaveicecore AT cristinapurcarea firstreportonantibioticresistanceandantimicrobialactivityofbacterialisolatesfrom13000yearoldcaveicecore
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First report on antibiotic resistance and antimicrobial activity of bacterial isolates from 13,000-year old cave ice core

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