1H -NMR Metabolomics Study of the Effect of Cisplatin and Casiopeina IIgly on MDA-MB-231 Breast Tumor Cells

The knowledge of the metabolic processes of designed metallodrugs for cancer treatment is an area that has been not profoundly studied. Casiopeina IIgly (CasIIgly), which belongs to the Casiopeínas® family, is a copper (II) coordination compound that has shown good biological activity against severa...

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Autores principales:	Karen Resendiz-Acevedo, Martha E. García-Aguilera, Nuria Esturau-Escofet, Lena Ruiz-Azuara
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	breast carcinoma metallodrug 1 H-NMR metabolomics Casiopeinas ® Copper Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/147e9e43b1174c519a1c2e5abaef51bd
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spelling	oai:doaj.org-article:147e9e43b1174c519a1c2e5abaef51bd2021-12-01T23:02:32Z1H -NMR Metabolomics Study of the Effect of Cisplatin and Casiopeina IIgly on MDA-MB-231 Breast Tumor Cells2296-889X10.3389/fmolb.2021.742859https://doaj.org/article/147e9e43b1174c519a1c2e5abaef51bd2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.742859/fullhttps://doaj.org/toc/2296-889XThe knowledge of the metabolic processes of designed metallodrugs for cancer treatment is an area that has been not profoundly studied. Casiopeina IIgly (CasIIgly), which belongs to the Casiopeínas® family, is a copper (II) coordination compound that has shown good biological activity against several cancer cells, low toxicity in normal cells, and antineoplastic activity in in vivo murine and xenografted models. In this work we employed a triple-negative highly metastatic breast carcinoma line (MDA-MB-231), which is one of the cancer types with a great mortality index, for 1H-NMR metabolomic analysis using cisplatin and CasIIgly, in order to quantify the effect of metallodrugs in the metabolic profile of this cell tumor line as a consequence of treatment at different times. Our findings indicate that cisplatin mainly contributes to phospholipid biosynthesis while CasIIgly affects processes such as carbohydrates and nucleotides metabolism. Also, we observed that CasIIgly treatment has an important and fast effect over MDA-MB-231 cell metabolism, which makes it a good alternative for treatment in this type of cancer.Karen Resendiz-AcevedoMartha E. García-AguileraNuria Esturau-EscofetLena Ruiz-AzuaraFrontiers Media S.A.articlebreast carcinomametallodrug1 H-NMR metabolomicsCasiopeinas ®CopperBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast carcinoma metallodrug 1 H-NMR metabolomics Casiopeinas ® Copper Biology (General) QH301-705.5
spellingShingle	breast carcinoma metallodrug 1 H-NMR metabolomics Casiopeinas ® Copper Biology (General) QH301-705.5 Karen Resendiz-Acevedo Martha E. García-Aguilera Nuria Esturau-Escofet Lena Ruiz-Azuara 1H -NMR Metabolomics Study of the Effect of Cisplatin and Casiopeina IIgly on MDA-MB-231 Breast Tumor Cells
description	The knowledge of the metabolic processes of designed metallodrugs for cancer treatment is an area that has been not profoundly studied. Casiopeina IIgly (CasIIgly), which belongs to the Casiopeínas® family, is a copper (II) coordination compound that has shown good biological activity against several cancer cells, low toxicity in normal cells, and antineoplastic activity in in vivo murine and xenografted models. In this work we employed a triple-negative highly metastatic breast carcinoma line (MDA-MB-231), which is one of the cancer types with a great mortality index, for 1H-NMR metabolomic analysis using cisplatin and CasIIgly, in order to quantify the effect of metallodrugs in the metabolic profile of this cell tumor line as a consequence of treatment at different times. Our findings indicate that cisplatin mainly contributes to phospholipid biosynthesis while CasIIgly affects processes such as carbohydrates and nucleotides metabolism. Also, we observed that CasIIgly treatment has an important and fast effect over MDA-MB-231 cell metabolism, which makes it a good alternative for treatment in this type of cancer.
format	article
author	Karen Resendiz-Acevedo Martha E. García-Aguilera Nuria Esturau-Escofet Lena Ruiz-Azuara
author_facet	Karen Resendiz-Acevedo Martha E. García-Aguilera Nuria Esturau-Escofet Lena Ruiz-Azuara
author_sort	Karen Resendiz-Acevedo
title	1H -NMR Metabolomics Study of the Effect of Cisplatin and Casiopeina IIgly on MDA-MB-231 Breast Tumor Cells
title_short	1H -NMR Metabolomics Study of the Effect of Cisplatin and Casiopeina IIgly on MDA-MB-231 Breast Tumor Cells
title_full	1H -NMR Metabolomics Study of the Effect of Cisplatin and Casiopeina IIgly on MDA-MB-231 Breast Tumor Cells
title_fullStr	1H -NMR Metabolomics Study of the Effect of Cisplatin and Casiopeina IIgly on MDA-MB-231 Breast Tumor Cells
title_full_unstemmed	1H -NMR Metabolomics Study of the Effect of Cisplatin and Casiopeina IIgly on MDA-MB-231 Breast Tumor Cells
title_sort	1h -nmr metabolomics study of the effect of cisplatin and casiopeina iigly on mda-mb-231 breast tumor cells
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/147e9e43b1174c519a1c2e5abaef51bd
work_keys_str_mv	AT karenresendizacevedo 1hnmrmetabolomicsstudyoftheeffectofcisplatinandcasiopeinaiiglyonmdamb231breasttumorcells AT marthaegarciaaguilera 1hnmrmetabolomicsstudyoftheeffectofcisplatinandcasiopeinaiiglyonmdamb231breasttumorcells AT nuriaesturauescofet 1hnmrmetabolomicsstudyoftheeffectofcisplatinandcasiopeinaiiglyonmdamb231breasttumorcells AT lenaruizazuara 1hnmrmetabolomicsstudyoftheeffectofcisplatinandcasiopeinaiiglyonmdamb231breasttumorcells
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1H -NMR Metabolomics Study of the Effect of Cisplatin and Casiopeina IIgly on MDA-MB-231 Breast Tumor Cells

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