Vulvar cancer: brain metastases. Clinical observation

Introduction. Brain metastases can occur in almost all gynecological malignancies and, despite modern therapeutic options, have a poor prognosis. Brain metastases from vulvar cancer are considered to be rare. In the literature, the reports on these cases have identity character. The aim is to sho...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nikolai A. Ognerubov, Tatyana S. Antipova, Natalya A. Kamneva
Formato:	article
Lenguaje:	RU
Publicado:	IP Habib O.N. 2021
Materias:	vulvar cancer brain metastases radiation therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/1489e821060e4d18ba58bd0f920370ad
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1489e821060e4d18ba58bd0f920370ad
record_format	dspace
spelling	oai:doaj.org-article:1489e821060e4d18ba58bd0f920370ad2021-11-30T17:03:34ZVulvar cancer: brain metastases. Clinical observation1815-14341815-144210.26442/18151434.2020.4.200299https://doaj.org/article/1489e821060e4d18ba58bd0f920370ad2021-02-01T00:00:00Zhttps://modernonco.orscience.ru/1815-1434/article/viewFile/61193/44278https://doaj.org/toc/1815-1434https://doaj.org/toc/1815-1442Introduction. Brain metastases can occur in almost all gynecological malignancies and, despite modern therapeutic options, have a poor prognosis. Brain metastases from vulvar cancer are considered to be rare. In the literature, the reports on these cases have identity character. The aim is to show clinical observation of the patient with vulvar cancer with brain metastases. Results. Patient S., 60 years old, with stage I р T1N0M0 vulvar cancer underwent vulvectomy in January 2018. During the histological study in the subepithelial layers were the areas of kraurosis with the growth of squamous cell keratinous carcinoma. Taking into account the prevalence of the tumor process, adjuvant treatment was not carried out. Two years later, in January 2020, there were focal symptoms in form of weakness in the left upper and lower limbs, an unsteady gait, a generalized weakness. During magnetic resonance imaging (MRI) of the brain in the occipital lobe paraventricular with intensive perifocal edema to the right was determined cystic-solid formation with rough edges which size was 293365 mm without clinically significant mass-effect. The middle structures were not displaced. Positron emission tomography-computed tomography (PET/CT) was performed to detect the prevalence of the tumor process. Data on the presence of the active specific process at the time of study were not received. Taking into account the absence of other indicators of generalization process, whole brain radiation therapy (single fraction dose of 3 Gy, total radiation dose of 30 Gy) was carried out, followed by the application of Temodal. The patient was examined in 6 months. There were no signs of progression. Conclusion. Brain metastases from vulvar cancer are considered to be rare. This clinical case is interesting because brain metastases have been the only manifestation of the progression of the tumor process in the absence of regional lymph nodes damage. The main diagnostic method is MRI of the brain. The use of PET/CT helps to detect the prevalence of the tumor process. The metastases have been detected after 36 months from the date of the initial diagnosis of the cancer. Radiation therapy is a method of choice of brain metastases treatment.Nikolai A. OgnerubovTatyana S. AntipovaNatalya A. KamnevaIP Habib O.N.articlevulvar cancerbrainmetastasesradiation therapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282RUСовременная онкология, Vol 22, Iss 4, Pp 130-133 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	vulvar cancer brain metastases radiation therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	vulvar cancer brain metastases radiation therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Nikolai A. Ognerubov Tatyana S. Antipova Natalya A. Kamneva Vulvar cancer: brain metastases. Clinical observation
description	Introduction. Brain metastases can occur in almost all gynecological malignancies and, despite modern therapeutic options, have a poor prognosis. Brain metastases from vulvar cancer are considered to be rare. In the literature, the reports on these cases have identity character. The aim is to show clinical observation of the patient with vulvar cancer with brain metastases. Results. Patient S., 60 years old, with stage I р T1N0M0 vulvar cancer underwent vulvectomy in January 2018. During the histological study in the subepithelial layers were the areas of kraurosis with the growth of squamous cell keratinous carcinoma. Taking into account the prevalence of the tumor process, adjuvant treatment was not carried out. Two years later, in January 2020, there were focal symptoms in form of weakness in the left upper and lower limbs, an unsteady gait, a generalized weakness. During magnetic resonance imaging (MRI) of the brain in the occipital lobe paraventricular with intensive perifocal edema to the right was determined cystic-solid formation with rough edges which size was 293365 mm without clinically significant mass-effect. The middle structures were not displaced. Positron emission tomography-computed tomography (PET/CT) was performed to detect the prevalence of the tumor process. Data on the presence of the active specific process at the time of study were not received. Taking into account the absence of other indicators of generalization process, whole brain radiation therapy (single fraction dose of 3 Gy, total radiation dose of 30 Gy) was carried out, followed by the application of Temodal. The patient was examined in 6 months. There were no signs of progression. Conclusion. Brain metastases from vulvar cancer are considered to be rare. This clinical case is interesting because brain metastases have been the only manifestation of the progression of the tumor process in the absence of regional lymph nodes damage. The main diagnostic method is MRI of the brain. The use of PET/CT helps to detect the prevalence of the tumor process. The metastases have been detected after 36 months from the date of the initial diagnosis of the cancer. Radiation therapy is a method of choice of brain metastases treatment.
format	article
author	Nikolai A. Ognerubov Tatyana S. Antipova Natalya A. Kamneva
author_facet	Nikolai A. Ognerubov Tatyana S. Antipova Natalya A. Kamneva
author_sort	Nikolai A. Ognerubov
title	Vulvar cancer: brain metastases. Clinical observation
title_short	Vulvar cancer: brain metastases. Clinical observation
title_full	Vulvar cancer: brain metastases. Clinical observation
title_fullStr	Vulvar cancer: brain metastases. Clinical observation
title_full_unstemmed	Vulvar cancer: brain metastases. Clinical observation
title_sort	vulvar cancer: brain metastases. clinical observation
publisher	IP Habib O.N.
publishDate	2021
url	https://doaj.org/article/1489e821060e4d18ba58bd0f920370ad
work_keys_str_mv	AT nikolaiaognerubov vulvarcancerbrainmetastasesclinicalobservation AT tatyanasantipova vulvarcancerbrainmetastasesclinicalobservation AT natalyaakamneva vulvarcancerbrainmetastasesclinicalobservation
_version_	1718406428068151296

Vulvar cancer: brain metastases. Clinical observation

Ejemplares similares