Periocular xanthogranuloma: A forgotten entity?

Charalampos Papagoras1, George Kitsos2, Paraskevi V Voulgari1, Anastasia K Zikou3, Maria I Argyropoulou3, Aikaterini Zioga4, Alexandros A Drosos11Rheumatology Clinic, Department of Internal Medicine; 2Department of Ophthalmology; 3Department of Clinical Imaging and Radiology, 4Department of Patholog...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Charalampos Papagoras, George Kitsos, Paraskevi V Voulgari, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/148bc55969bd438f95fd97a3afed667f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:148bc55969bd438f95fd97a3afed667f
record_format	dspace
spelling	oai:doaj.org-article:148bc55969bd438f95fd97a3afed667f2021-12-02T05:56:21ZPeriocular xanthogranuloma: A forgotten entity?1177-54671177-5483https://doaj.org/article/148bc55969bd438f95fd97a3afed667f2010-03-01T00:00:00Zhttp://www.dovepress.com/periocular-xanthogranuloma-a-forgotten-entity-a4033https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Charalampos Papagoras1, George Kitsos2, Paraskevi V Voulgari1, Anastasia K Zikou3, Maria I Argyropoulou3, Aikaterini Zioga4, Alexandros A Drosos11Rheumatology Clinic, Department of Internal Medicine; 2Department of Ophthalmology; 3Department of Clinical Imaging and Radiology, 4Department of Pathology, Medical School, University of Ioannina, Ioannina, GreeceAbstract: Periocular xanthogranulomatous diseases are a rare group of disorders which are characterized by a predilection to affect the orbit and ocular adnexa and special histopathological features, in particular infiltrates comprising non-Langerhans-derived foamy histiocytes and Touton giant cells. The differential diagnosis is difficult and occasionally definite diagnosis cannot be established even after clinical and histopathological findings are taken together. We describe a case of a middle-aged man who presented with a 10-year history of voluminous eyelid swelling with concomitant late-onset atopic manifestations, namely bronchial asthma and allergic rhinitis with nasal polyps. After thorough clinical and laboratory investigation, including a biopsy of the eyelid, we classified the patient&rsquo;s disease to a rare entity that has been relatively recently described: periocular xanthogranuloma associated with adult-onset asthma. In a review of the literature, no prospective trials concerning the treatment of this disease were found. The literature mainly contained case reports and case series in which corticosteroids and chemotherapy with alkylating agents have been reported to be beneficial. We treated our patient with a combination of oral corticosteroids and cyclophosphamide pulses and we observed substantial regression of the eyelid masses together with a normalization of systemic immunologic abnormalities.Keywords: periocular xanthogranuloma, adult-onset asthma, non-Langerhans histiocytoses, cyclophosphamide, methylprednisolone Charalampos PapagorasGeorge KitsosParaskevi V Voulgariet alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 105-110 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Charalampos Papagoras George Kitsos Paraskevi V Voulgari et al Periocular xanthogranuloma: A forgotten entity?
description	Charalampos Papagoras1, George Kitsos2, Paraskevi V Voulgari1, Anastasia K Zikou3, Maria I Argyropoulou3, Aikaterini Zioga4, Alexandros A Drosos11Rheumatology Clinic, Department of Internal Medicine; 2Department of Ophthalmology; 3Department of Clinical Imaging and Radiology, 4Department of Pathology, Medical School, University of Ioannina, Ioannina, GreeceAbstract: Periocular xanthogranulomatous diseases are a rare group of disorders which are characterized by a predilection to affect the orbit and ocular adnexa and special histopathological features, in particular infiltrates comprising non-Langerhans-derived foamy histiocytes and Touton giant cells. The differential diagnosis is difficult and occasionally definite diagnosis cannot be established even after clinical and histopathological findings are taken together. We describe a case of a middle-aged man who presented with a 10-year history of voluminous eyelid swelling with concomitant late-onset atopic manifestations, namely bronchial asthma and allergic rhinitis with nasal polyps. After thorough clinical and laboratory investigation, including a biopsy of the eyelid, we classified the patient&rsquo;s disease to a rare entity that has been relatively recently described: periocular xanthogranuloma associated with adult-onset asthma. In a review of the literature, no prospective trials concerning the treatment of this disease were found. The literature mainly contained case reports and case series in which corticosteroids and chemotherapy with alkylating agents have been reported to be beneficial. We treated our patient with a combination of oral corticosteroids and cyclophosphamide pulses and we observed substantial regression of the eyelid masses together with a normalization of systemic immunologic abnormalities.Keywords: periocular xanthogranuloma, adult-onset asthma, non-Langerhans histiocytoses, cyclophosphamide, methylprednisolone
format	article
author	Charalampos Papagoras George Kitsos Paraskevi V Voulgari et al
author_facet	Charalampos Papagoras George Kitsos Paraskevi V Voulgari et al
author_sort	Charalampos Papagoras
title	Periocular xanthogranuloma: A forgotten entity?
title_short	Periocular xanthogranuloma: A forgotten entity?
title_full	Periocular xanthogranuloma: A forgotten entity?
title_fullStr	Periocular xanthogranuloma: A forgotten entity?
title_full_unstemmed	Periocular xanthogranuloma: A forgotten entity?
title_sort	periocular xanthogranuloma: a forgotten entity?
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/148bc55969bd438f95fd97a3afed667f
work_keys_str_mv	AT charalampospapagoras periocularxanthogranulomaaforgottenentity AT georgekitsos periocularxanthogranulomaaforgottenentity AT paraskevivvoulgari periocularxanthogranulomaaforgottenentity AT etal periocularxanthogranulomaaforgottenentity
_version_	1718400094102880256

Periocular xanthogranuloma: A forgotten entity?

Ejemplares similares