Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats

The use of sodium-glucose transport protein 2 (SGLT2) inhibitors for the treatment of diabetes has been associated with euglycemic ketoacidosis and increased glucose production and glucagon secretion. Here Perry et al. show that these effects rely on both insulinopenia and dehydration, and thus sugg...

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Autores principales:	Rachel J. Perry, Aviva Rabin-Court, Joongyu D. Song, Rebecca L. Cardone, Yongliang Wang, Richard G. Kibbey, Gerald I. Shulman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1491a567866a435e9938ca80389140c5
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spelling	oai:doaj.org-article:1491a567866a435e9938ca80389140c52021-12-02T15:35:59ZDehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats10.1038/s41467-019-08466-w2041-1723https://doaj.org/article/1491a567866a435e9938ca80389140c52019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08466-whttps://doaj.org/toc/2041-1723The use of sodium-glucose transport protein 2 (SGLT2) inhibitors for the treatment of diabetes has been associated with euglycemic ketoacidosis and increased glucose production and glucagon secretion. Here Perry et al. show that these effects rely on both insulinopenia and dehydration, and thus suggest ways to manage the side effects associated with the use of SGLT2 inhibitors.Rachel J. PerryAviva Rabin-CourtJoongyu D. SongRebecca L. CardoneYongliang WangRichard G. KibbeyGerald I. ShulmanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rachel J. Perry Aviva Rabin-Court Joongyu D. Song Rebecca L. Cardone Yongliang Wang Richard G. Kibbey Gerald I. Shulman Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats
description	The use of sodium-glucose transport protein 2 (SGLT2) inhibitors for the treatment of diabetes has been associated with euglycemic ketoacidosis and increased glucose production and glucagon secretion. Here Perry et al. show that these effects rely on both insulinopenia and dehydration, and thus suggest ways to manage the side effects associated with the use of SGLT2 inhibitors.
format	article
author	Rachel J. Perry Aviva Rabin-Court Joongyu D. Song Rebecca L. Cardone Yongliang Wang Richard G. Kibbey Gerald I. Shulman
author_facet	Rachel J. Perry Aviva Rabin-Court Joongyu D. Song Rebecca L. Cardone Yongliang Wang Richard G. Kibbey Gerald I. Shulman
author_sort	Rachel J. Perry
title	Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats
title_short	Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats
title_full	Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats
title_fullStr	Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats
title_full_unstemmed	Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats
title_sort	dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in sglt2 inhibitor-treated rats
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1491a567866a435e9938ca80389140c5
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Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats

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