Synthetic geopolymers for controlled delivery of oxycodone: adjustable and nanostructured porosity enables tunable and sustained drug release.
In this article we for the first time present a fully synthetic mesoporous geopolymer drug carrier for controlled release of opioids. Nanoparticulate precursor powders with different Al/Si-ratios were synthesized by a sol-gel route and used in the preparation of different geopolymers, which could be...
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Public Library of Science (PLoS)
2011
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oai:doaj.org-article:1492d07ff4c549a7991f08f7e4a65adf2021-11-18T06:57:17ZSynthetic geopolymers for controlled delivery of oxycodone: adjustable and nanostructured porosity enables tunable and sustained drug release.1932-620310.1371/journal.pone.0017759https://doaj.org/article/1492d07ff4c549a7991f08f7e4a65adf2011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21423616/?tool=EBIhttps://doaj.org/toc/1932-6203In this article we for the first time present a fully synthetic mesoporous geopolymer drug carrier for controlled release of opioids. Nanoparticulate precursor powders with different Al/Si-ratios were synthesized by a sol-gel route and used in the preparation of different geopolymers, which could be structurally tailored by adjusting the Al/Si-ratio and the curing temperatures. In particular, it was shown that the pore sizes of the geopolymers decreased with increasing Al/Si ratio and that completely mesoporous geopolymers could be produced from precursor particles with the Al/Si ratio 2:1. The mesoporosity was shown to be associated with a sustained and linear in vitro release profile of the opioid oxycodone. A clinically relevant release period of about 12 h was obtained by adjusting the size of the pellets. The easily fabricated and tunable geopolymers presented in this study constitute a novel approach in the development of controlled release formulations, not only for opioids, but whenever the clinical indication is best treated with a constant supply of drugs and when the mechanical stability of the delivery vehicle is crucial.Johan ForsgrenChristian PedersenMaria StrømmeHåkan EngqvistPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 3, p e17759 (2011) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Medicine R Science Q |
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Medicine R Science Q Johan Forsgren Christian Pedersen Maria Strømme Håkan Engqvist Synthetic geopolymers for controlled delivery of oxycodone: adjustable and nanostructured porosity enables tunable and sustained drug release. |
| description |
In this article we for the first time present a fully synthetic mesoporous geopolymer drug carrier for controlled release of opioids. Nanoparticulate precursor powders with different Al/Si-ratios were synthesized by a sol-gel route and used in the preparation of different geopolymers, which could be structurally tailored by adjusting the Al/Si-ratio and the curing temperatures. In particular, it was shown that the pore sizes of the geopolymers decreased with increasing Al/Si ratio and that completely mesoporous geopolymers could be produced from precursor particles with the Al/Si ratio 2:1. The mesoporosity was shown to be associated with a sustained and linear in vitro release profile of the opioid oxycodone. A clinically relevant release period of about 12 h was obtained by adjusting the size of the pellets. The easily fabricated and tunable geopolymers presented in this study constitute a novel approach in the development of controlled release formulations, not only for opioids, but whenever the clinical indication is best treated with a constant supply of drugs and when the mechanical stability of the delivery vehicle is crucial. |
| format |
article |
| author |
Johan Forsgren Christian Pedersen Maria Strømme Håkan Engqvist |
| author_facet |
Johan Forsgren Christian Pedersen Maria Strømme Håkan Engqvist |
| author_sort |
Johan Forsgren |
| title |
Synthetic geopolymers for controlled delivery of oxycodone: adjustable and nanostructured porosity enables tunable and sustained drug release. |
| title_short |
Synthetic geopolymers for controlled delivery of oxycodone: adjustable and nanostructured porosity enables tunable and sustained drug release. |
| title_full |
Synthetic geopolymers for controlled delivery of oxycodone: adjustable and nanostructured porosity enables tunable and sustained drug release. |
| title_fullStr |
Synthetic geopolymers for controlled delivery of oxycodone: adjustable and nanostructured porosity enables tunable and sustained drug release. |
| title_full_unstemmed |
Synthetic geopolymers for controlled delivery of oxycodone: adjustable and nanostructured porosity enables tunable and sustained drug release. |
| title_sort |
synthetic geopolymers for controlled delivery of oxycodone: adjustable and nanostructured porosity enables tunable and sustained drug release. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/1492d07ff4c549a7991f08f7e4a65adf |
| work_keys_str_mv |
AT johanforsgren syntheticgeopolymersforcontrolleddeliveryofoxycodoneadjustableandnanostructuredporosityenablestunableandsustaineddrugrelease AT christianpedersen syntheticgeopolymersforcontrolleddeliveryofoxycodoneadjustableandnanostructuredporosityenablestunableandsustaineddrugrelease AT mariastrømme syntheticgeopolymersforcontrolleddeliveryofoxycodoneadjustableandnanostructuredporosityenablestunableandsustaineddrugrelease AT hakanengqvist syntheticgeopolymersforcontrolleddeliveryofoxycodoneadjustableandnanostructuredporosityenablestunableandsustaineddrugrelease |
| _version_ |
1718424151110189056 |