Recent developments in the nanostructured materials functionalized with ruthenium complexes for targeted drug delivery to tumors

Prakash Thangavel,1 Buddolla Viswanath,1 Sanghyo Kim1,2 1Department of Bionanotechnology, Gachon University, Bokjeong-Dong, Sujeong-Gu, Seongnam-Si, Gyeonggi-Do, 2Graduate Gachon Medical Research Institute, Gil Medical Center, Incheon, Republic of Korea Abstract: In recent years, the field of meta...

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Autores principales:	Thangavel P, Viswanath B, Kim S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Ruthenium complexes synthesis nanostructured materials cytotoxic effect targeted delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1495aff1f628420cbf4d5c96df76d1f3
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spelling	oai:doaj.org-article:1495aff1f628420cbf4d5c96df76d1f32021-12-02T02:53:19ZRecent developments in the nanostructured materials functionalized with ruthenium complexes for targeted drug delivery to tumors1178-2013https://doaj.org/article/1495aff1f628420cbf4d5c96df76d1f32017-04-01T00:00:00Zhttps://www.dovepress.com/recent-developments-in-the-nanostructured-materials-functionalized-wit-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Prakash Thangavel,1 Buddolla Viswanath,1 Sanghyo Kim1,2 1Department of Bionanotechnology, Gachon University, Bokjeong-Dong, Sujeong-Gu, Seongnam-Si, Gyeonggi-Do, 2Graduate Gachon Medical Research Institute, Gil Medical Center, Incheon, Republic of Korea Abstract: In recent years, the field of metal-based drugs has been dominated by other existing precious metal drugs, and many researchers have focused their attention on the synthesis of various ruthenium (Ru) complexes due to their potential medical and pharmaceutical applications. The beneficial properties of Ru, which make it a highly promising therapeutic agent, include its variable oxidation states, low toxicity, high selectivity for diseased cells, ligand exchange properties, and the ability to mimic iron binding to biomolecules. In addition, Ru complexes have favorable adsorption properties, along with excellent photochemical and photophysical properties, which make them promising tools for photodynamic therapy. At present, nanostructured materials functionalized with Ru complexes have become an efficient way to administer Ru-based anticancer drugs for cancer treatment. In this review, the recent developments in the nanostructured materials functionalized with Ru complexes for targeted drug delivery to tumors are discussed. In addition, information on “traditional” (ie, non-nanostructured) Ru-based cancer therapies is included in a precise manner. Keywords: metallodrugs, nanotechnology, cancer treatment, cell apoptosis, DNA damage, toxicityThangavel PViswanath BKim SDove Medical PressarticleRuthenium complexessynthesisnanostructured materialscytotoxic effecttargeted deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 2749-2758 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ruthenium complexes synthesis nanostructured materials cytotoxic effect targeted delivery Medicine (General) R5-920
spellingShingle	Ruthenium complexes synthesis nanostructured materials cytotoxic effect targeted delivery Medicine (General) R5-920 Thangavel P Viswanath B Kim S Recent developments in the nanostructured materials functionalized with ruthenium complexes for targeted drug delivery to tumors
description	Prakash Thangavel,1 Buddolla Viswanath,1 Sanghyo Kim1,2 1Department of Bionanotechnology, Gachon University, Bokjeong-Dong, Sujeong-Gu, Seongnam-Si, Gyeonggi-Do, 2Graduate Gachon Medical Research Institute, Gil Medical Center, Incheon, Republic of Korea Abstract: In recent years, the field of metal-based drugs has been dominated by other existing precious metal drugs, and many researchers have focused their attention on the synthesis of various ruthenium (Ru) complexes due to their potential medical and pharmaceutical applications. The beneficial properties of Ru, which make it a highly promising therapeutic agent, include its variable oxidation states, low toxicity, high selectivity for diseased cells, ligand exchange properties, and the ability to mimic iron binding to biomolecules. In addition, Ru complexes have favorable adsorption properties, along with excellent photochemical and photophysical properties, which make them promising tools for photodynamic therapy. At present, nanostructured materials functionalized with Ru complexes have become an efficient way to administer Ru-based anticancer drugs for cancer treatment. In this review, the recent developments in the nanostructured materials functionalized with Ru complexes for targeted drug delivery to tumors are discussed. In addition, information on “traditional” (ie, non-nanostructured) Ru-based cancer therapies is included in a precise manner. Keywords: metallodrugs, nanotechnology, cancer treatment, cell apoptosis, DNA damage, toxicity
format	article
author	Thangavel P Viswanath B Kim S
author_facet	Thangavel P Viswanath B Kim S
author_sort	Thangavel P
title	Recent developments in the nanostructured materials functionalized with ruthenium complexes for targeted drug delivery to tumors
title_short	Recent developments in the nanostructured materials functionalized with ruthenium complexes for targeted drug delivery to tumors
title_full	Recent developments in the nanostructured materials functionalized with ruthenium complexes for targeted drug delivery to tumors
title_fullStr	Recent developments in the nanostructured materials functionalized with ruthenium complexes for targeted drug delivery to tumors
title_full_unstemmed	Recent developments in the nanostructured materials functionalized with ruthenium complexes for targeted drug delivery to tumors
title_sort	recent developments in the nanostructured materials functionalized with ruthenium complexes for targeted drug delivery to tumors
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/1495aff1f628420cbf4d5c96df76d1f3
work_keys_str_mv	AT thangavelp recentdevelopmentsinthenanostructuredmaterialsfunctionalizedwithrutheniumcomplexesfortargeteddrugdeliverytotumors AT viswanathb recentdevelopmentsinthenanostructuredmaterialsfunctionalizedwithrutheniumcomplexesfortargeteddrugdeliverytotumors AT kims recentdevelopmentsinthenanostructuredmaterialsfunctionalizedwithrutheniumcomplexesfortargeteddrugdeliverytotumors
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Recent developments in the nanostructured materials functionalized with ruthenium complexes for targeted drug delivery to tumors

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