Fast and equilibrium CEST imaging of brain tumor patients at 3T

Chemical exchange saturation transfer (CEST) MRI, versatile for detecting endogenous mobile proteins and tissue pH, has proved valuable in tumor imaging. However, CEST MRI scans are often performed under non-equilibrium conditions, which confound tissue characterization. This study proposed a quasi-...

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Autores principales:	Yin Wu, Zhou Liu, Qian Yang, Liyan Zou, Fan Zhang, Long Qian, Xin Liu, Hairong Zheng, Dehong Luo, Phillip Zhe Sun
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Amide proton transfer Chemical exchange saturation transfer Quasi-steady-state (QUASS) Tumor Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/14971f3d4d8344f7864e16771618e886
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spelling	oai:doaj.org-article:14971f3d4d8344f7864e16771618e8862021-12-04T04:33:59ZFast and equilibrium CEST imaging of brain tumor patients at 3T2213-158210.1016/j.nicl.2021.102890https://doaj.org/article/14971f3d4d8344f7864e16771618e8862022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S221315822100334Xhttps://doaj.org/toc/2213-1582Chemical exchange saturation transfer (CEST) MRI, versatile for detecting endogenous mobile proteins and tissue pH, has proved valuable in tumor imaging. However, CEST MRI scans are often performed under non-equilibrium conditions, which confound tissue characterization. This study proposed a quasi-steady-state (QUASS) CEST MRI algorithm to standardize fast and accurate tumor imaging at 3 T. The CEST signal evolution was modeled by longitudinal relaxation rate during relaxation delay (Td) and spinlock relaxation during RF saturation time (Ts), from which the QUASS CEST effect is derived. Numerical simulation and human MR imaging experiments (7 healthy volunteers and 19 tumor patients) were conducted at 3 T to compare the CEST measurements obtained under two representative experimental conditions. In addition, amide proton transfer (APT), combined magnetization transfer (MT) and nuclear overhauser enhancement (NOE) effects, and direct water saturation were isolated using a 3-pool Lorentzian fitting in white matter and gray matter of healthy volunteers and for patients in the contralateral normal-appearing white matter and tumor regions. Finally, the student's t-test was performed between conventional and QUASS CEST measurements. The routine APT and combined MT & NOE measures significantly varied with Ts and Td (P < .001) and were significantly smaller than the corresponding QUASS indices (P < .001). In contrast, the results from the QUASS reconstruction showed little dependence on the scan protocol (P > .05), indicating the accuracy and robustness of QUASS CEST MRI for tumor imaging. To summarize, the QUASS CEST reconstruction algorithm enables fast and accurate tumor CEST imaging at 3 T, promising to expedite and standardize clinical CEST MRI.Yin WuZhou LiuQian YangLiyan ZouFan ZhangLong QianXin LiuHairong ZhengDehong LuoPhillip Zhe SunElsevierarticleAmide proton transferChemical exchange saturation transferQuasi-steady-state (QUASS)TumorComputer applications to medicine. Medical informaticsR858-859.7Neurology. Diseases of the nervous systemRC346-429ENNeuroImage: Clinical, Vol 33, Iss , Pp 102890- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Amide proton transfer Chemical exchange saturation transfer Quasi-steady-state (QUASS) Tumor Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Amide proton transfer Chemical exchange saturation transfer Quasi-steady-state (QUASS) Tumor Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429 Yin Wu Zhou Liu Qian Yang Liyan Zou Fan Zhang Long Qian Xin Liu Hairong Zheng Dehong Luo Phillip Zhe Sun Fast and equilibrium CEST imaging of brain tumor patients at 3T
description	Chemical exchange saturation transfer (CEST) MRI, versatile for detecting endogenous mobile proteins and tissue pH, has proved valuable in tumor imaging. However, CEST MRI scans are often performed under non-equilibrium conditions, which confound tissue characterization. This study proposed a quasi-steady-state (QUASS) CEST MRI algorithm to standardize fast and accurate tumor imaging at 3 T. The CEST signal evolution was modeled by longitudinal relaxation rate during relaxation delay (Td) and spinlock relaxation during RF saturation time (Ts), from which the QUASS CEST effect is derived. Numerical simulation and human MR imaging experiments (7 healthy volunteers and 19 tumor patients) were conducted at 3 T to compare the CEST measurements obtained under two representative experimental conditions. In addition, amide proton transfer (APT), combined magnetization transfer (MT) and nuclear overhauser enhancement (NOE) effects, and direct water saturation were isolated using a 3-pool Lorentzian fitting in white matter and gray matter of healthy volunteers and for patients in the contralateral normal-appearing white matter and tumor regions. Finally, the student's t-test was performed between conventional and QUASS CEST measurements. The routine APT and combined MT & NOE measures significantly varied with Ts and Td (P < .001) and were significantly smaller than the corresponding QUASS indices (P < .001). In contrast, the results from the QUASS reconstruction showed little dependence on the scan protocol (P > .05), indicating the accuracy and robustness of QUASS CEST MRI for tumor imaging. To summarize, the QUASS CEST reconstruction algorithm enables fast and accurate tumor CEST imaging at 3 T, promising to expedite and standardize clinical CEST MRI.
format	article
author	Yin Wu Zhou Liu Qian Yang Liyan Zou Fan Zhang Long Qian Xin Liu Hairong Zheng Dehong Luo Phillip Zhe Sun
author_facet	Yin Wu Zhou Liu Qian Yang Liyan Zou Fan Zhang Long Qian Xin Liu Hairong Zheng Dehong Luo Phillip Zhe Sun
author_sort	Yin Wu
title	Fast and equilibrium CEST imaging of brain tumor patients at 3T
title_short	Fast and equilibrium CEST imaging of brain tumor patients at 3T
title_full	Fast and equilibrium CEST imaging of brain tumor patients at 3T
title_fullStr	Fast and equilibrium CEST imaging of brain tumor patients at 3T
title_full_unstemmed	Fast and equilibrium CEST imaging of brain tumor patients at 3T
title_sort	fast and equilibrium cest imaging of brain tumor patients at 3t
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/14971f3d4d8344f7864e16771618e886
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_version_	1718372953686540288

Fast and equilibrium CEST imaging of brain tumor patients at 3T

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