IMMUNE STATUS AND CYTOKINE PROFILE IN CHILDREN WITH PERINATAL DAMAGES OF CNS

Abstract. The aim of the study was to verify etiological agents of CNS perinatal damages in children of early age and to study peculiarities of immune and cytokine statuses during pathogenetically grounded therapy.618 children aged from 1 month till 3 years were examined. Changes of neurologic statu...

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Autor principal:	O. V. Nikogosova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	perinatal infection neurology immunocorrection Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/1497dfdd21ff4e83b393ff2cc59f44cb
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spelling	oai:doaj.org-article:1497dfdd21ff4e83b393ff2cc59f44cb2021-11-18T08:03:41ZIMMUNE STATUS AND CYTOKINE PROFILE IN CHILDREN WITH PERINATAL DAMAGES OF CNS1563-06252313-741X10.15789/1563-0625-2005-4-425-432https://doaj.org/article/1497dfdd21ff4e83b393ff2cc59f44cb2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/503https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The aim of the study was to verify etiological agents of CNS perinatal damages in children of early age and to study peculiarities of immune and cytokine statuses during pathogenetically grounded therapy.618 children aged from 1 month till 3 years were examined. Changes of neurologic status were interrogated and complete standard paraclinical examination was carried out. Basic clinical groups were formed.Immunoassay program, which included verification of a causative agent and determination of indices of cellular and humoral immunities, was used to identify a causative agent and to determin infectious activity. Direct methods of investigation which reveal a causative agent and indirect methods which register specific immune response were used. Patients were divided into groups on the basis of etiological agent.The program of pharmacotherapy was based on findings, immune status and in particular immune mediators. This program included specific anti-infectious therapy and adequate immunorehabilitation. Data analysis was made for groups of patients who got symptomatic therapy in neurologic disease and who got immunocorrective and anti-infectious therapy in addition to standard treatment. Comparison of clinical characteristics showed considerable improvement of patients in the latter group, what correlated with laboratorial data. Normalization of principal indices of immune and cytokine statuses which ensure development of anti-infectious immunity resulted in persistent infectious remission, noticeable improvement of clinical state of the invalidity rate.O. V. NikogosovaSPb RAACIarticleperinatal infectionneurologyimmunocorrectionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 7, Iss 4, Pp 425-432 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	perinatal infection neurology immunocorrection Immunologic diseases. Allergy RC581-607
spellingShingle	perinatal infection neurology immunocorrection Immunologic diseases. Allergy RC581-607 O. V. Nikogosova IMMUNE STATUS AND CYTOKINE PROFILE IN CHILDREN WITH PERINATAL DAMAGES OF CNS
description	Abstract. The aim of the study was to verify etiological agents of CNS perinatal damages in children of early age and to study peculiarities of immune and cytokine statuses during pathogenetically grounded therapy.618 children aged from 1 month till 3 years were examined. Changes of neurologic status were interrogated and complete standard paraclinical examination was carried out. Basic clinical groups were formed.Immunoassay program, which included verification of a causative agent and determination of indices of cellular and humoral immunities, was used to identify a causative agent and to determin infectious activity. Direct methods of investigation which reveal a causative agent and indirect methods which register specific immune response were used. Patients were divided into groups on the basis of etiological agent.The program of pharmacotherapy was based on findings, immune status and in particular immune mediators. This program included specific anti-infectious therapy and adequate immunorehabilitation. Data analysis was made for groups of patients who got symptomatic therapy in neurologic disease and who got immunocorrective and anti-infectious therapy in addition to standard treatment. Comparison of clinical characteristics showed considerable improvement of patients in the latter group, what correlated with laboratorial data. Normalization of principal indices of immune and cytokine statuses which ensure development of anti-infectious immunity resulted in persistent infectious remission, noticeable improvement of clinical state of the invalidity rate.
format	article
author	O. V. Nikogosova
author_facet	O. V. Nikogosova
author_sort	O. V. Nikogosova
title	IMMUNE STATUS AND CYTOKINE PROFILE IN CHILDREN WITH PERINATAL DAMAGES OF CNS
title_short	IMMUNE STATUS AND CYTOKINE PROFILE IN CHILDREN WITH PERINATAL DAMAGES OF CNS
title_full	IMMUNE STATUS AND CYTOKINE PROFILE IN CHILDREN WITH PERINATAL DAMAGES OF CNS
title_fullStr	IMMUNE STATUS AND CYTOKINE PROFILE IN CHILDREN WITH PERINATAL DAMAGES OF CNS
title_full_unstemmed	IMMUNE STATUS AND CYTOKINE PROFILE IN CHILDREN WITH PERINATAL DAMAGES OF CNS
title_sort	immune status and cytokine profile in children with perinatal damages of cns
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/1497dfdd21ff4e83b393ff2cc59f44cb
work_keys_str_mv	AT ovnikogosova immunestatusandcytokineprofileinchildrenwithperinataldamagesofcns
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IMMUNE STATUS AND CYTOKINE PROFILE IN CHILDREN WITH PERINATAL DAMAGES OF CNS

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