5-epi-Sinuleptolide from Soft Corals of the Genus Sinularia Exerts Cytotoxic Effects on Pancreatic Cancer Cell Lines via the Inhibition of JAK2/STAT3, AKT, and ERK Activity

Pancreatic ductal adenocarcinoma is one of the most lethal malignancies: more than half of patients are diagnosed with a metastatic disease, which is associated with a five-year survival rate of only 3%. 5-epi-Sinuleptolide, a norditerpene isolated from Sinularia...

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Autores principales:	Wan-Chi Tsai, Wen-Hung Wang, Bo-Cian Huang, Chiung-Yao Huang, Jyh-Horng Sheu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	soft corals 5-<i>epi</i>-sinuleptolide pancreatic cancer cytotoxicity STAT3 Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/149d14d5b9cc4beba84d801fae5c268c
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spelling	oai:doaj.org-article:149d14d5b9cc4beba84d801fae5c268c2021-11-25T18:28:32Z5-<i>epi</i>-Sinuleptolide from Soft Corals of the Genus <i>Sinularia</i> Exerts Cytotoxic Effects on Pancreatic Cancer Cell Lines via the Inhibition of JAK2/STAT3, AKT, and ERK Activity10.3390/molecules262269321420-3049https://doaj.org/article/149d14d5b9cc4beba84d801fae5c268c2021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6932https://doaj.org/toc/1420-3049Pancreatic ductal adenocarcinoma is one of the most lethal malignancies: more than half of patients are diagnosed with a metastatic disease, which is associated with a five-year survival rate of only 3%. 5-<i>epi</i>-Sinuleptolide, a norditerpene isolated from <i>Sinularia</i> sp., has been demonstrated to possess cytotoxic activity against cancer cells. However, the cytotoxicity against pancreatic cancer cells and the related mechanisms are unknown. The aim of this study was to evaluate the anti-pancreatic cancer potential of 5-<i>epi</i>-sinuleptolide and to elucidate the underlying mechanisms. The inhibitory effects of 5-<i>epi</i>-sinuleptolide treatment on the proliferation of pancreatic cancer cells were determined and the results showed that 5-<i>epi</i>-sinuleptolide treatment inhibited cell proliferation, induced apoptosis and G2/M cell cycle arrest, and suppressed the invasion of pancreatic cancer cells. The results of western blotting further revealed that 5-<i>epi</i>-sinuleptolide could inhibit JAK2/STAT3, AKT, and ERK phosphorylation, which may account for the diverse cytotoxic effects of 5-<i>epi</i>-sinuleptolide. Taken together, our present investigation unveils a new therapeutic and anti-metastatic potential of 5-<i>epi</i>-sinuleptolide for pancreatic cancer treatment.Wan-Chi TsaiWen-Hung WangBo-Cian HuangChiung-Yao HuangJyh-Horng SheuMDPI AGarticlesoft corals5-<i>epi</i>-sinuleptolidepancreatic cancercytotoxicitySTAT3Organic chemistryQD241-441ENMolecules, Vol 26, Iss 6932, p 6932 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	soft corals 5-<i>epi</i>-sinuleptolide pancreatic cancer cytotoxicity STAT3 Organic chemistry QD241-441
spellingShingle	soft corals 5-<i>epi</i>-sinuleptolide pancreatic cancer cytotoxicity STAT3 Organic chemistry QD241-441 Wan-Chi Tsai Wen-Hung Wang Bo-Cian Huang Chiung-Yao Huang Jyh-Horng Sheu 5-<i>epi</i>-Sinuleptolide from Soft Corals of the Genus <i>Sinularia</i> Exerts Cytotoxic Effects on Pancreatic Cancer Cell Lines via the Inhibition of JAK2/STAT3, AKT, and ERK Activity
description	Pancreatic ductal adenocarcinoma is one of the most lethal malignancies: more than half of patients are diagnosed with a metastatic disease, which is associated with a five-year survival rate of only 3%. 5-<i>epi</i>-Sinuleptolide, a norditerpene isolated from <i>Sinularia</i> sp., has been demonstrated to possess cytotoxic activity against cancer cells. However, the cytotoxicity against pancreatic cancer cells and the related mechanisms are unknown. The aim of this study was to evaluate the anti-pancreatic cancer potential of 5-<i>epi</i>-sinuleptolide and to elucidate the underlying mechanisms. The inhibitory effects of 5-<i>epi</i>-sinuleptolide treatment on the proliferation of pancreatic cancer cells were determined and the results showed that 5-<i>epi</i>-sinuleptolide treatment inhibited cell proliferation, induced apoptosis and G2/M cell cycle arrest, and suppressed the invasion of pancreatic cancer cells. The results of western blotting further revealed that 5-<i>epi</i>-sinuleptolide could inhibit JAK2/STAT3, AKT, and ERK phosphorylation, which may account for the diverse cytotoxic effects of 5-<i>epi</i>-sinuleptolide. Taken together, our present investigation unveils a new therapeutic and anti-metastatic potential of 5-<i>epi</i>-sinuleptolide for pancreatic cancer treatment.
format	article
author	Wan-Chi Tsai Wen-Hung Wang Bo-Cian Huang Chiung-Yao Huang Jyh-Horng Sheu
author_facet	Wan-Chi Tsai Wen-Hung Wang Bo-Cian Huang Chiung-Yao Huang Jyh-Horng Sheu
author_sort	Wan-Chi Tsai
title	5-<i>epi</i>-Sinuleptolide from Soft Corals of the Genus <i>Sinularia</i> Exerts Cytotoxic Effects on Pancreatic Cancer Cell Lines via the Inhibition of JAK2/STAT3, AKT, and ERK Activity
title_short	5-<i>epi</i>-Sinuleptolide from Soft Corals of the Genus <i>Sinularia</i> Exerts Cytotoxic Effects on Pancreatic Cancer Cell Lines via the Inhibition of JAK2/STAT3, AKT, and ERK Activity
title_full	5-<i>epi</i>-Sinuleptolide from Soft Corals of the Genus <i>Sinularia</i> Exerts Cytotoxic Effects on Pancreatic Cancer Cell Lines via the Inhibition of JAK2/STAT3, AKT, and ERK Activity
title_fullStr	5-<i>epi</i>-Sinuleptolide from Soft Corals of the Genus <i>Sinularia</i> Exerts Cytotoxic Effects on Pancreatic Cancer Cell Lines via the Inhibition of JAK2/STAT3, AKT, and ERK Activity
title_full_unstemmed	5-<i>epi</i>-Sinuleptolide from Soft Corals of the Genus <i>Sinularia</i> Exerts Cytotoxic Effects on Pancreatic Cancer Cell Lines via the Inhibition of JAK2/STAT3, AKT, and ERK Activity
title_sort	5-<i>epi</i>-sinuleptolide from soft corals of the genus <i>sinularia</i> exerts cytotoxic effects on pancreatic cancer cell lines via the inhibition of jak2/stat3, akt, and erk activity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/149d14d5b9cc4beba84d801fae5c268c
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5-<i>epi</i>-Sinuleptolide from Soft Corals of the Genus <i>Sinularia</i> Exerts Cytotoxic Effects on Pancreatic Cancer Cell Lines via the Inhibition of JAK2/STAT3, AKT, and ERK Activity

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