AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis

Nonalcoholic steatohepatitis (NASH) and associated liver fibrosis have limited therapy options. Here the authors report a novel adiponectin-based dual agonist for adiponectin receptors 1 and 2 with a longer half-life, and show that it ameliorates NASH and liver fibrosis in mouse models.

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Autores principales:	Hongjiao Xu, Qian Zhao, Nazi Song, Zhibin Yan, Runfeng Lin, Shuohan Wu, Lili Jiang, Sihua Hong, Junqiu Xie, Huihao Zhou, Rui Wang, Xianxing Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/14a1b270a4d24c8f81f31ac78a992843
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spelling	oai:doaj.org-article:14a1b270a4d24c8f81f31ac78a9928432021-12-02T17:31:24ZAdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis10.1038/s41467-020-19668-y2041-1723https://doaj.org/article/14a1b270a4d24c8f81f31ac78a9928432020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19668-yhttps://doaj.org/toc/2041-1723Nonalcoholic steatohepatitis (NASH) and associated liver fibrosis have limited therapy options. Here the authors report a novel adiponectin-based dual agonist for adiponectin receptors 1 and 2 with a longer half-life, and show that it ameliorates NASH and liver fibrosis in mouse models.Hongjiao XuQian ZhaoNazi SongZhibin YanRunfeng LinShuohan WuLili JiangSihua HongJunqiu XieHuihao ZhouRui WangXianxing JiangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hongjiao Xu Qian Zhao Nazi Song Zhibin Yan Runfeng Lin Shuohan Wu Lili Jiang Sihua Hong Junqiu Xie Huihao Zhou Rui Wang Xianxing Jiang AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis
description	Nonalcoholic steatohepatitis (NASH) and associated liver fibrosis have limited therapy options. Here the authors report a novel adiponectin-based dual agonist for adiponectin receptors 1 and 2 with a longer half-life, and show that it ameliorates NASH and liver fibrosis in mouse models.
format	article
author	Hongjiao Xu Qian Zhao Nazi Song Zhibin Yan Runfeng Lin Shuohan Wu Lili Jiang Sihua Hong Junqiu Xie Huihao Zhou Rui Wang Xianxing Jiang
author_facet	Hongjiao Xu Qian Zhao Nazi Song Zhibin Yan Runfeng Lin Shuohan Wu Lili Jiang Sihua Hong Junqiu Xie Huihao Zhou Rui Wang Xianxing Jiang
author_sort	Hongjiao Xu
title	AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis
title_short	AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis
title_full	AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis
title_fullStr	AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis
title_full_unstemmed	AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis
title_sort	adipor1/adipor2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/14a1b270a4d24c8f81f31ac78a992843
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AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis

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