Phylogeographical Analyses and Antibiotic Resistance Genes of <italic toggle="yes">Acinetobacter johnsonii</italic> Highlight Its Clinical Relevance

ABSTRACT Acinetobacter johnsonii has been severely understudied and its population structure and the presence of antibiotic resistance genes (ARGs) are very much uncertain. Our phylogeographical analysis shows that intercontinental transmission has occurred frequently and that different lineages are...

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Autores principales:	Santiago Castillo-Ramírez, Valeria Mateo-Estrada, Gerardo Gonzalez-Rocha, Andrés Opazo-Capurro
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	Acinetobacter johnsonii population structure antibiotic resistance emerging pathogens horizontal gene transfer population genomics Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/14a49888001847ed86fd81d20deb8d8d
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spelling	oai:doaj.org-article:14a49888001847ed86fd81d20deb8d8d2021-11-15T15:30:51ZPhylogeographical Analyses and Antibiotic Resistance Genes of <italic toggle="yes">Acinetobacter johnsonii</italic> Highlight Its Clinical Relevance10.1128/mSphere.00581-202379-5042https://doaj.org/article/14a49888001847ed86fd81d20deb8d8d2020-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00581-20https://doaj.org/toc/2379-5042ABSTRACT Acinetobacter johnsonii has been severely understudied and its population structure and the presence of antibiotic resistance genes (ARGs) are very much uncertain. Our phylogeographical analysis shows that intercontinental transmission has occurred frequently and that different lineages are circulating within single countries; notably, clinical and nonclinical strains are not well differentiated from one another. Importantly, in this species recombination is a significant source of single nucleotide polymorphisms. Furthermore, our results show this species could be an important reservoir of ARGs since it has a significant amount of ARGs, and many of them show signals of horizontal gene transfer. Thus, this study clearly points out the clinical importance of A. johnsonii and the urgent need to better appreciate its genomic diversity.Santiago Castillo-RamírezValeria Mateo-EstradaGerardo Gonzalez-RochaAndrés Opazo-CapurroAmerican Society for MicrobiologyarticleAcinetobacter johnsoniipopulation structureantibiotic resistanceemerging pathogenshorizontal gene transferpopulation genomicsMicrobiologyQR1-502ENmSphere, Vol 5, Iss 4 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Acinetobacter johnsonii population structure antibiotic resistance emerging pathogens horizontal gene transfer population genomics Microbiology QR1-502
spellingShingle	Acinetobacter johnsonii population structure antibiotic resistance emerging pathogens horizontal gene transfer population genomics Microbiology QR1-502 Santiago Castillo-Ramírez Valeria Mateo-Estrada Gerardo Gonzalez-Rocha Andrés Opazo-Capurro Phylogeographical Analyses and Antibiotic Resistance Genes of <italic toggle="yes">Acinetobacter johnsonii</italic> Highlight Its Clinical Relevance
description	ABSTRACT Acinetobacter johnsonii has been severely understudied and its population structure and the presence of antibiotic resistance genes (ARGs) are very much uncertain. Our phylogeographical analysis shows that intercontinental transmission has occurred frequently and that different lineages are circulating within single countries; notably, clinical and nonclinical strains are not well differentiated from one another. Importantly, in this species recombination is a significant source of single nucleotide polymorphisms. Furthermore, our results show this species could be an important reservoir of ARGs since it has a significant amount of ARGs, and many of them show signals of horizontal gene transfer. Thus, this study clearly points out the clinical importance of A. johnsonii and the urgent need to better appreciate its genomic diversity.
format	article
author	Santiago Castillo-Ramírez Valeria Mateo-Estrada Gerardo Gonzalez-Rocha Andrés Opazo-Capurro
author_facet	Santiago Castillo-Ramírez Valeria Mateo-Estrada Gerardo Gonzalez-Rocha Andrés Opazo-Capurro
author_sort	Santiago Castillo-Ramírez
title	Phylogeographical Analyses and Antibiotic Resistance Genes of <italic toggle="yes">Acinetobacter johnsonii</italic> Highlight Its Clinical Relevance
title_short	Phylogeographical Analyses and Antibiotic Resistance Genes of <italic toggle="yes">Acinetobacter johnsonii</italic> Highlight Its Clinical Relevance
title_full	Phylogeographical Analyses and Antibiotic Resistance Genes of <italic toggle="yes">Acinetobacter johnsonii</italic> Highlight Its Clinical Relevance
title_fullStr	Phylogeographical Analyses and Antibiotic Resistance Genes of <italic toggle="yes">Acinetobacter johnsonii</italic> Highlight Its Clinical Relevance
title_full_unstemmed	Phylogeographical Analyses and Antibiotic Resistance Genes of <italic toggle="yes">Acinetobacter johnsonii</italic> Highlight Its Clinical Relevance
title_sort	phylogeographical analyses and antibiotic resistance genes of <italic toggle="yes">acinetobacter johnsonii</italic> highlight its clinical relevance
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/14a49888001847ed86fd81d20deb8d8d
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Phylogeographical Analyses and Antibiotic Resistance Genes of <italic toggle="yes">Acinetobacter johnsonii</italic> Highlight Its Clinical Relevance

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