Long Non-coding RNA Uc.48+ Small Interfering RNA Alleviates Neuroinflammatory Hyperalgesia in Gp120-Treated Rats via the P2Y12 Receptor

Human immunodeficiency virus envelope glycoprotein 120 (gp120) leads to hyperalgesia. Long non-coding RNAs are characterized by the lack of a protein-coding sequence and may contribute to the development and maintenance of inflammatory and neuroinflammatory pain. Rats with neuroinflammatory pain wer...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lichao Peng, Bing Wu, Liran Shi, Lifang Zou, Lin Li, Runan Yang, Xiumei Xu, Guilin Li, Shuangmei Liu, Chunping Zhang, Shangdong Liang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	dorsal root ganglia HIV gp120-associated neuroinflammatory pain long non-coding RNA small interfering RNA P2Y12 receptor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/14a58a6433434ac39fedc2ffeb47e42a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:14a58a6433434ac39fedc2ffeb47e42a
record_format	dspace
spelling	oai:doaj.org-article:14a58a6433434ac39fedc2ffeb47e42a2021-12-01T08:49:48ZLong Non-coding RNA Uc.48+ Small Interfering RNA Alleviates Neuroinflammatory Hyperalgesia in Gp120-Treated Rats via the P2Y12 Receptor1662-453X10.3389/fnins.2021.663962https://doaj.org/article/14a58a6433434ac39fedc2ffeb47e42a2021-07-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.663962/fullhttps://doaj.org/toc/1662-453XHuman immunodeficiency virus envelope glycoprotein 120 (gp120) leads to hyperalgesia. Long non-coding RNAs are characterized by the lack of a protein-coding sequence and may contribute to the development and maintenance of inflammatory and neuroinflammatory pain. Rats with neuroinflammatory pain were established by gp120 treatment, which is featured by intensified pain behaviors. Long non-coding RNA uc.48+ was increased in the dorsal root ganglia of gp120-treated rats, and small interfering RNA that targets uc.48+ markedly alleviated hyperalgesia in gp120-treated rats. Notably, uc.48+ overexpression increased P2Y12 expression in control rats dorsal root ganglia and induced hyperalgesia. Uc.48+ small interfering RNA inhibited P2Y12 expression in gp120-treated rats. Uc.48+ potentiated P2Y12 receptor functions in the neurons and heterologous cells. Therefore, uc.48+ siRNA treatment reduced the upregulation of P2Y12 expression and function in DRG neurons, and, hence, alleviated hyperalgesia in gp120-treated rats.Lichao PengBing WuBing WuLiran ShiLiran ShiLifang ZouLifang ZouLin LiLin LiRunan YangRunan YangXiumei XuXiumei XuGuilin LiGuilin LiShuangmei LiuShuangmei LiuChunping ZhangChunping ZhangShangdong LiangShangdong LiangFrontiers Media S.A.articledorsal root gangliaHIV gp120-associated neuroinflammatory painlong non-coding RNAsmall interfering RNAP2Y12 receptorNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dorsal root ganglia HIV gp120-associated neuroinflammatory pain long non-coding RNA small interfering RNA P2Y12 receptor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	dorsal root ganglia HIV gp120-associated neuroinflammatory pain long non-coding RNA small interfering RNA P2Y12 receptor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Lichao Peng Bing Wu Bing Wu Liran Shi Liran Shi Lifang Zou Lifang Zou Lin Li Lin Li Runan Yang Runan Yang Xiumei Xu Xiumei Xu Guilin Li Guilin Li Shuangmei Liu Shuangmei Liu Chunping Zhang Chunping Zhang Shangdong Liang Shangdong Liang Long Non-coding RNA Uc.48+ Small Interfering RNA Alleviates Neuroinflammatory Hyperalgesia in Gp120-Treated Rats via the P2Y12 Receptor
description	Human immunodeficiency virus envelope glycoprotein 120 (gp120) leads to hyperalgesia. Long non-coding RNAs are characterized by the lack of a protein-coding sequence and may contribute to the development and maintenance of inflammatory and neuroinflammatory pain. Rats with neuroinflammatory pain were established by gp120 treatment, which is featured by intensified pain behaviors. Long non-coding RNA uc.48+ was increased in the dorsal root ganglia of gp120-treated rats, and small interfering RNA that targets uc.48+ markedly alleviated hyperalgesia in gp120-treated rats. Notably, uc.48+ overexpression increased P2Y12 expression in control rats dorsal root ganglia and induced hyperalgesia. Uc.48+ small interfering RNA inhibited P2Y12 expression in gp120-treated rats. Uc.48+ potentiated P2Y12 receptor functions in the neurons and heterologous cells. Therefore, uc.48+ siRNA treatment reduced the upregulation of P2Y12 expression and function in DRG neurons, and, hence, alleviated hyperalgesia in gp120-treated rats.
format	article
author	Lichao Peng Bing Wu Bing Wu Liran Shi Liran Shi Lifang Zou Lifang Zou Lin Li Lin Li Runan Yang Runan Yang Xiumei Xu Xiumei Xu Guilin Li Guilin Li Shuangmei Liu Shuangmei Liu Chunping Zhang Chunping Zhang Shangdong Liang Shangdong Liang
author_facet	Lichao Peng Bing Wu Bing Wu Liran Shi Liran Shi Lifang Zou Lifang Zou Lin Li Lin Li Runan Yang Runan Yang Xiumei Xu Xiumei Xu Guilin Li Guilin Li Shuangmei Liu Shuangmei Liu Chunping Zhang Chunping Zhang Shangdong Liang Shangdong Liang
author_sort	Lichao Peng
title	Long Non-coding RNA Uc.48+ Small Interfering RNA Alleviates Neuroinflammatory Hyperalgesia in Gp120-Treated Rats via the P2Y12 Receptor
title_short	Long Non-coding RNA Uc.48+ Small Interfering RNA Alleviates Neuroinflammatory Hyperalgesia in Gp120-Treated Rats via the P2Y12 Receptor
title_full	Long Non-coding RNA Uc.48+ Small Interfering RNA Alleviates Neuroinflammatory Hyperalgesia in Gp120-Treated Rats via the P2Y12 Receptor
title_fullStr	Long Non-coding RNA Uc.48+ Small Interfering RNA Alleviates Neuroinflammatory Hyperalgesia in Gp120-Treated Rats via the P2Y12 Receptor
title_full_unstemmed	Long Non-coding RNA Uc.48+ Small Interfering RNA Alleviates Neuroinflammatory Hyperalgesia in Gp120-Treated Rats via the P2Y12 Receptor
title_sort	long non-coding rna uc.48+ small interfering rna alleviates neuroinflammatory hyperalgesia in gp120-treated rats via the p2y12 receptor
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/14a58a6433434ac39fedc2ffeb47e42a
work_keys_str_mv	AT lichaopeng longnoncodingrnauc48smallinterferingrnaalleviatesneuroinflammatoryhyperalgesiaingp120treatedratsviathep2y12receptor AT bingwu longnoncodingrnauc48smallinterferingrnaalleviatesneuroinflammatoryhyperalgesiaingp120treatedratsviathep2y12receptor AT bingwu longnoncodingrnauc48smallinterferingrnaalleviatesneuroinflammatoryhyperalgesiaingp120treatedratsviathep2y12receptor AT liranshi longnoncodingrnauc48smallinterferingrnaalleviatesneuroinflammatoryhyperalgesiaingp120treatedratsviathep2y12receptor AT liranshi longnoncodingrnauc48smallinterferingrnaalleviatesneuroinflammatoryhyperalgesiaingp120treatedratsviathep2y12receptor AT lifangzou longnoncodingrnauc48smallinterferingrnaalleviatesneuroinflammatoryhyperalgesiaingp120treatedratsviathep2y12receptor AT lifangzou longnoncodingrnauc48smallinterferingrnaalleviatesneuroinflammatoryhyperalgesiaingp120treatedratsviathep2y12receptor AT linli longnoncodingrnauc48smallinterferingrnaalleviatesneuroinflammatoryhyperalgesiaingp120treatedratsviathep2y12receptor AT linli longnoncodingrnauc48smallinterferingrnaalleviatesneuroinflammatoryhyperalgesiaingp120treatedratsviathep2y12receptor AT runanyang longnoncodingrnauc48smallinterferingrnaalleviatesneuroinflammatoryhyperalgesiaingp120treatedratsviathep2y12receptor AT runanyang longnoncodingrnauc48smallinterferingrnaalleviatesneuroinflammatoryhyperalgesiaingp120treatedratsviathep2y12receptor AT xiumeixu longnoncodingrnauc48smallinterferingrnaalleviatesneuroinflammatoryhyperalgesiaingp120treatedratsviathep2y12receptor AT xiumeixu longnoncodingrnauc48smallinterferingrnaalleviatesneuroinflammatoryhyperalgesiaingp120treatedratsviathep2y12receptor AT guilinli longnoncodingrnauc48smallinterferingrnaalleviatesneuroinflammatoryhyperalgesiaingp120treatedratsviathep2y12receptor AT guilinli longnoncodingrnauc48smallinterferingrnaalleviatesneuroinflammatoryhyperalgesiaingp120treatedratsviathep2y12receptor AT shuangmeiliu longnoncodingrnauc48smallinterferingrnaalleviatesneuroinflammatoryhyperalgesiaingp120treatedratsviathep2y12receptor AT shuangmeiliu longnoncodingrnauc48smallinterferingrnaalleviatesneuroinflammatoryhyperalgesiaingp120treatedratsviathep2y12receptor AT chunpingzhang longnoncodingrnauc48smallinterferingrnaalleviatesneuroinflammatoryhyperalgesiaingp120treatedratsviathep2y12receptor AT chunpingzhang longnoncodingrnauc48smallinterferingrnaalleviatesneuroinflammatoryhyperalgesiaingp120treatedratsviathep2y12receptor AT shangdongliang longnoncodingrnauc48smallinterferingrnaalleviatesneuroinflammatoryhyperalgesiaingp120treatedratsviathep2y12receptor AT shangdongliang longnoncodingrnauc48smallinterferingrnaalleviatesneuroinflammatoryhyperalgesiaingp120treatedratsviathep2y12receptor
_version_	1718405339135606784

Long Non-coding RNA Uc.48+ Small Interfering RNA Alleviates Neuroinflammatory Hyperalgesia in Gp120-Treated Rats via the P2Y12 Receptor

Ejemplares similares