The relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment

Abstract We assessed the structure–function relationship of the human cholinergic system and hypothesized that structural measures are associated with short-latency sensory afferent inhibition (SAI), an electrophysiological measure of central cholinergic signal transmission. Healthy volunteers (n = ...

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Autores principales:	Jessica Peter, Isabella Mayer, Thomas Kammer, Lora Minkova, Jacob Lahr, Stefan Klöppel, Michel J. Grothe, Michael Orth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/14a640e78bd34437a2d0eb958651d24e
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spelling	oai:doaj.org-article:14a640e78bd34437a2d0eb958651d24e2021-12-02T16:28:06ZThe relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment10.1038/s41598-021-95573-82045-2322https://doaj.org/article/14a640e78bd34437a2d0eb958651d24e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95573-8https://doaj.org/toc/2045-2322Abstract We assessed the structure–function relationship of the human cholinergic system and hypothesized that structural measures are associated with short-latency sensory afferent inhibition (SAI), an electrophysiological measure of central cholinergic signal transmission. Healthy volunteers (n = 36) and patients with mild cognitive impairment (MCI, n = 20) underwent median nerve SAI and 3T structural MRI to determine the volume of the basal forebrain and the thalamus. Patients with MCI had smaller basal forebrain (p < 0.001) or thalamus volumes (p < 0.001) than healthy volunteers. Healthy SAI responders (> 10% SAI) had more basal forebrain volume than non-responders (p = 0.004) or patients with MCI (p < 0.001). More basal forebrain volume was associated with stronger SAI in healthy volunteers (r = 0.33, p < 0.05) but not patients with MCI. There was no significant relationship between thalamus volumes and SAI. Basal forebrain volume is associated with cholinergic function (SAI) in healthy volunteers but not in MCI patients. The in-vivo investigation of the structure–function relationship could further our understanding of the human cholinergic system in patients with suspected or known cholinergic system degeneration.Jessica PeterIsabella MayerThomas KammerLora MinkovaJacob LahrStefan KlöppelMichel J. GrotheMichael OrthNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jessica Peter Isabella Mayer Thomas Kammer Lora Minkova Jacob Lahr Stefan Klöppel Michel J. Grothe Michael Orth The relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment
description	Abstract We assessed the structure–function relationship of the human cholinergic system and hypothesized that structural measures are associated with short-latency sensory afferent inhibition (SAI), an electrophysiological measure of central cholinergic signal transmission. Healthy volunteers (n = 36) and patients with mild cognitive impairment (MCI, n = 20) underwent median nerve SAI and 3T structural MRI to determine the volume of the basal forebrain and the thalamus. Patients with MCI had smaller basal forebrain (p < 0.001) or thalamus volumes (p < 0.001) than healthy volunteers. Healthy SAI responders (> 10% SAI) had more basal forebrain volume than non-responders (p = 0.004) or patients with MCI (p < 0.001). More basal forebrain volume was associated with stronger SAI in healthy volunteers (r = 0.33, p < 0.05) but not patients with MCI. There was no significant relationship between thalamus volumes and SAI. Basal forebrain volume is associated with cholinergic function (SAI) in healthy volunteers but not in MCI patients. The in-vivo investigation of the structure–function relationship could further our understanding of the human cholinergic system in patients with suspected or known cholinergic system degeneration.
format	article
author	Jessica Peter Isabella Mayer Thomas Kammer Lora Minkova Jacob Lahr Stefan Klöppel Michel J. Grothe Michael Orth
author_facet	Jessica Peter Isabella Mayer Thomas Kammer Lora Minkova Jacob Lahr Stefan Klöppel Michel J. Grothe Michael Orth
author_sort	Jessica Peter
title	The relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment
title_short	The relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment
title_full	The relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment
title_fullStr	The relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment
title_full_unstemmed	The relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment
title_sort	relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/14a640e78bd34437a2d0eb958651d24e
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The relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment

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