Intravitreal gas injection for the treatment of diabetic macular edema

Dominic McHugh, Bhaskar Gupta, Manzar Saeed King&#39;s College Hospital, Denmark Hill, London, England, UK Purpose: This study investigates the efficacy of an intravitreal gas injection in inducing a posterior vitreous detachment (PVD) in patients with clinically significant diabetic macular...

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Autores principales:	McHugh D, Gupta B, Saeed M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/14a924cabdb049f382559168205489d6
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spelling	oai:doaj.org-article:14a924cabdb049f382559168205489d62021-12-02T03:23:53ZIntravitreal gas injection for the treatment of diabetic macular edema1177-54671177-5483https://doaj.org/article/14a924cabdb049f382559168205489d62011-10-01T00:00:00Zhttp://www.dovepress.com/intravitreal-gas-injection-for-the-treatment-of-diabetic-macular-edema-a8548https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Dominic McHugh, Bhaskar Gupta, Manzar Saeed King&#39;s College Hospital, Denmark Hill, London, England, UK Purpose: This study investigates the efficacy of an intravitreal gas injection in inducing a posterior vitreous detachment (PVD) in patients with clinically significant diabetic macular edema refractory to laser therapy. Methods: A local ethics committee-approved technique of an intravitreal injection of pure perfluoropropane gas (C3F8) was performed for all participants. After a period of prone positioning, the patients underwent regular and detailed clinical review. Main outcome measures: The induction of a PVD, change in macular thickness, change in visual acuity. Results: A PVD was induced in all five eyes with subsequent signs of reduction in macular thickness and resolution of exudates. Mean visual improvement was 11 ETDRS (Early Treatment Diabetic Retinopathy Study) letters (range 4&ndash;21). Apart from a transient vitreous hemorrhage in one eye, there were no significant treatment-related complications. Conclusion: The induction of a PVD by pneumatic retinopexy appears to have a significant influence on diabetic macular edema in eyes which have not successfully responded to macular laser therapy. A randomized clinical trial is justified on the basis of the initial promising data. Keywords: optical coherence tomography, OCT, posterior vitreous detachment, perfluoropropaneMcHugh DGupta BSaeed MDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 1543-1548 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 McHugh D Gupta B Saeed M Intravitreal gas injection for the treatment of diabetic macular edema
description	Dominic McHugh, Bhaskar Gupta, Manzar Saeed King&#39;s College Hospital, Denmark Hill, London, England, UK Purpose: This study investigates the efficacy of an intravitreal gas injection in inducing a posterior vitreous detachment (PVD) in patients with clinically significant diabetic macular edema refractory to laser therapy. Methods: A local ethics committee-approved technique of an intravitreal injection of pure perfluoropropane gas (C3F8) was performed for all participants. After a period of prone positioning, the patients underwent regular and detailed clinical review. Main outcome measures: The induction of a PVD, change in macular thickness, change in visual acuity. Results: A PVD was induced in all five eyes with subsequent signs of reduction in macular thickness and resolution of exudates. Mean visual improvement was 11 ETDRS (Early Treatment Diabetic Retinopathy Study) letters (range 4&ndash;21). Apart from a transient vitreous hemorrhage in one eye, there were no significant treatment-related complications. Conclusion: The induction of a PVD by pneumatic retinopexy appears to have a significant influence on diabetic macular edema in eyes which have not successfully responded to macular laser therapy. A randomized clinical trial is justified on the basis of the initial promising data. Keywords: optical coherence tomography, OCT, posterior vitreous detachment, perfluoropropane
format	article
author	McHugh D Gupta B Saeed M
author_facet	McHugh D Gupta B Saeed M
author_sort	McHugh D
title	Intravitreal gas injection for the treatment of diabetic macular edema
title_short	Intravitreal gas injection for the treatment of diabetic macular edema
title_full	Intravitreal gas injection for the treatment of diabetic macular edema
title_fullStr	Intravitreal gas injection for the treatment of diabetic macular edema
title_full_unstemmed	Intravitreal gas injection for the treatment of diabetic macular edema
title_sort	intravitreal gas injection for the treatment of diabetic macular edema
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/14a924cabdb049f382559168205489d6
work_keys_str_mv	AT mchughd intravitrealgasinjectionforthetreatmentofdiabeticmacularedema AT guptab intravitrealgasinjectionforthetreatmentofdiabeticmacularedema AT saeedm intravitrealgasinjectionforthetreatmentofdiabeticmacularedema
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Intravitreal gas injection for the treatment of diabetic macular edema

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