MicroRNA-493 suppresses tumor growth, invasion and metastasis of lung cancer by regulating E2F1.

miRNAs have been proposed to be key regulators of progression and metastasis in cancer. However, an understanding of their roles and molecular mechanisms is needed to provide deeper insights for better therapeutic opportunities. In this study we investigated the role and mechanism of miR-493 in the...

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Autores principales:	Yixue Gu, Ye Cheng, Ying Song, Zhijie Zhang, Min Deng, Chengkun Wang, Guopei Zheng, Zhimin He
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/14adb6e29b9f479e815c01e28603a6ea
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spelling	oai:doaj.org-article:14adb6e29b9f479e815c01e28603a6ea2021-11-25T06:05:32ZMicroRNA-493 suppresses tumor growth, invasion and metastasis of lung cancer by regulating E2F1.1932-620310.1371/journal.pone.0102602https://doaj.org/article/14adb6e29b9f479e815c01e28603a6ea2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25105419/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203miRNAs have been proposed to be key regulators of progression and metastasis in cancer. However, an understanding of their roles and molecular mechanisms is needed to provide deeper insights for better therapeutic opportunities. In this study we investigated the role and mechanism of miR-493 in the development and progression of nonsmall-cell lung cancer (NSCLC). Our data indicated that the expression of miR-493 was markedly reduced in pulmonary carcinoma. The ectopic expression of miR-493 impaired cell growth and invasion in vitro and in vivo. Mechanically, miR-493 commonly directly targeted E2F1, which resulted in a robust reduction of the expression of mRNA and protein. This effect, in turn, decreased the growth, invasion and metastasis of lung cancer cells. Our findings highlight the importance of miR-493 dysfunction in promoting tumor progression, and implicate miR-493 as a potential therapeutic target in lung cancer.Yixue GuYe ChengYing SongZhijie ZhangMin DengChengkun WangGuopei ZhengZhimin HePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e102602 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yixue Gu Ye Cheng Ying Song Zhijie Zhang Min Deng Chengkun Wang Guopei Zheng Zhimin He MicroRNA-493 suppresses tumor growth, invasion and metastasis of lung cancer by regulating E2F1.
description	miRNAs have been proposed to be key regulators of progression and metastasis in cancer. However, an understanding of their roles and molecular mechanisms is needed to provide deeper insights for better therapeutic opportunities. In this study we investigated the role and mechanism of miR-493 in the development and progression of nonsmall-cell lung cancer (NSCLC). Our data indicated that the expression of miR-493 was markedly reduced in pulmonary carcinoma. The ectopic expression of miR-493 impaired cell growth and invasion in vitro and in vivo. Mechanically, miR-493 commonly directly targeted E2F1, which resulted in a robust reduction of the expression of mRNA and protein. This effect, in turn, decreased the growth, invasion and metastasis of lung cancer cells. Our findings highlight the importance of miR-493 dysfunction in promoting tumor progression, and implicate miR-493 as a potential therapeutic target in lung cancer.
format	article
author	Yixue Gu Ye Cheng Ying Song Zhijie Zhang Min Deng Chengkun Wang Guopei Zheng Zhimin He
author_facet	Yixue Gu Ye Cheng Ying Song Zhijie Zhang Min Deng Chengkun Wang Guopei Zheng Zhimin He
author_sort	Yixue Gu
title	MicroRNA-493 suppresses tumor growth, invasion and metastasis of lung cancer by regulating E2F1.
title_short	MicroRNA-493 suppresses tumor growth, invasion and metastasis of lung cancer by regulating E2F1.
title_full	MicroRNA-493 suppresses tumor growth, invasion and metastasis of lung cancer by regulating E2F1.
title_fullStr	MicroRNA-493 suppresses tumor growth, invasion and metastasis of lung cancer by regulating E2F1.
title_full_unstemmed	MicroRNA-493 suppresses tumor growth, invasion and metastasis of lung cancer by regulating E2F1.
title_sort	microrna-493 suppresses tumor growth, invasion and metastasis of lung cancer by regulating e2f1.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/14adb6e29b9f479e815c01e28603a6ea
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MicroRNA-493 suppresses tumor growth, invasion and metastasis of lung cancer by regulating E2F1.

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