Targeting the Gut Microbiome in Prader-Willi Syndrome

Overwhelming evidence demonstrates an important role of the gut microbiome in the development of a wide range of diseases, including obesity, metabolic disorders, and mental health symptoms. Indeed, interventions targeting the gut microbiome are being actively investigated as a therapeutic strategy...

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Autores principales:	Marta Ramon-Krauel, Montse Amat-Bou, Mercedes Serrano, Antonio F. Martinez-Monseny, Carles Lerin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	gut microbiota probiotics Prader-Willi syndrome obesity mental health symptoms Medicine R
Acceso en línea:	https://doaj.org/article/14adf4c6e9af4b97985e574983df019d
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spelling	oai:doaj.org-article:14adf4c6e9af4b97985e574983df019d2021-11-25T18:01:47ZTargeting the Gut Microbiome in Prader-Willi Syndrome10.3390/jcm102253282077-0383https://doaj.org/article/14adf4c6e9af4b97985e574983df019d2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5328https://doaj.org/toc/2077-0383Overwhelming evidence demonstrates an important role of the gut microbiome in the development of a wide range of diseases, including obesity, metabolic disorders, and mental health symptoms. Indeed, interventions targeting the gut microbiome are being actively investigated as a therapeutic strategy to tackle these diseases. Given that obesity and mental health symptoms are both hallmarks of Prader-Willi syndrome, targeting the gut microbiome may be a promising therapeutical strategy. Only a few studies have investigated the gut microbiome in the context of Prader-Willi syndrome and assessed the efficacy of probiotic supplementation as a therapeutic strategy for this disease. Here, we review the knowledge obtained to this date regarding the gut microbiome in individuals with Prader-Willi syndrome. The limited evidence available indicate that probiotic supplementation improves some metabolic and mental health aspects, however further studies are warranted to determine whether targeting the gut microbiome may constitute a safe and efficient strategy to treat individuals with Prader-Willi syndrome.Marta Ramon-KrauelMontse Amat-BouMercedes SerranoAntonio F. Martinez-MonsenyCarles LerinMDPI AGarticlegut microbiotaprobioticsPrader-Willi syndromeobesitymental health symptomsMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5328, p 5328 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gut microbiota probiotics Prader-Willi syndrome obesity mental health symptoms Medicine R
spellingShingle	gut microbiota probiotics Prader-Willi syndrome obesity mental health symptoms Medicine R Marta Ramon-Krauel Montse Amat-Bou Mercedes Serrano Antonio F. Martinez-Monseny Carles Lerin Targeting the Gut Microbiome in Prader-Willi Syndrome
description	Overwhelming evidence demonstrates an important role of the gut microbiome in the development of a wide range of diseases, including obesity, metabolic disorders, and mental health symptoms. Indeed, interventions targeting the gut microbiome are being actively investigated as a therapeutic strategy to tackle these diseases. Given that obesity and mental health symptoms are both hallmarks of Prader-Willi syndrome, targeting the gut microbiome may be a promising therapeutical strategy. Only a few studies have investigated the gut microbiome in the context of Prader-Willi syndrome and assessed the efficacy of probiotic supplementation as a therapeutic strategy for this disease. Here, we review the knowledge obtained to this date regarding the gut microbiome in individuals with Prader-Willi syndrome. The limited evidence available indicate that probiotic supplementation improves some metabolic and mental health aspects, however further studies are warranted to determine whether targeting the gut microbiome may constitute a safe and efficient strategy to treat individuals with Prader-Willi syndrome.
format	article
author	Marta Ramon-Krauel Montse Amat-Bou Mercedes Serrano Antonio F. Martinez-Monseny Carles Lerin
author_facet	Marta Ramon-Krauel Montse Amat-Bou Mercedes Serrano Antonio F. Martinez-Monseny Carles Lerin
author_sort	Marta Ramon-Krauel
title	Targeting the Gut Microbiome in Prader-Willi Syndrome
title_short	Targeting the Gut Microbiome in Prader-Willi Syndrome
title_full	Targeting the Gut Microbiome in Prader-Willi Syndrome
title_fullStr	Targeting the Gut Microbiome in Prader-Willi Syndrome
title_full_unstemmed	Targeting the Gut Microbiome in Prader-Willi Syndrome
title_sort	targeting the gut microbiome in prader-willi syndrome
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/14adf4c6e9af4b97985e574983df019d
work_keys_str_mv	AT martaramonkrauel targetingthegutmicrobiomeinpraderwillisyndrome AT montseamatbou targetingthegutmicrobiomeinpraderwillisyndrome AT mercedesserrano targetingthegutmicrobiomeinpraderwillisyndrome AT antoniofmartinezmonseny targetingthegutmicrobiomeinpraderwillisyndrome AT carleslerin targetingthegutmicrobiomeinpraderwillisyndrome
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Targeting the Gut Microbiome in Prader-Willi Syndrome

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