Bio-Performance of Hydrothermally and Plasma-Treated Titanium: The New Generation of Vascular Stents

The research presented herein follows an urgent global need for the development of novel surface engineering techniques that would allow the fabrication of next-generation cardiovascular stents, which would drastically reduce cardiovascular diseases (CVD). The combination of hydrothermal treatment (...

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Autores principales:	Metka Benčina, Niharika Rawat, Katja Lakota, Snežna Sodin-Šemrl, Aleš Iglič, Ita Junkar
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cardiovascular disease metallic stents hydrothermal treatment non-thermal plasma treatment TiO<sub>2</sub> Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/14b264dcdcd54b319f60be0e8c2abeff
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spelling	oai:doaj.org-article:14b264dcdcd54b319f60be0e8c2abeff2021-11-11T17:17:00ZBio-Performance of Hydrothermally and Plasma-Treated Titanium: The New Generation of Vascular Stents10.3390/ijms2221118581422-00671661-6596https://doaj.org/article/14b264dcdcd54b319f60be0e8c2abeff2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11858https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The research presented herein follows an urgent global need for the development of novel surface engineering techniques that would allow the fabrication of next-generation cardiovascular stents, which would drastically reduce cardiovascular diseases (CVD). The combination of hydrothermal treatment (HT) and treatment with highly reactive oxygen plasma (P) allowed for the formation of an oxygen-rich nanostructured surface. The morphology, surface roughness, chemical composition and wettability of the newly prepared oxide layer on the Ti substrate were characterized by scanning electron microscopy (SEM) with energy-dispersive X-ray analysis (EDX), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS) and water contact angle (WCA) analysis. The alteration of surface characteristics influenced the material’s bio-performance; platelet aggregation and activation was reduced on surfaces treated by hydrothermal treatment, as well as after plasma treatment. Moreover, it was shown that surfaces treated by both treatment procedures (HT and P) promoted the adhesion and proliferation of vascular endothelial cells, while at the same time inhibiting the adhesion and proliferation of vascular smooth muscle cells. The combination of both techniques presents a novel approach for the fabrication of vascular implants, with superior characteristics.Metka BenčinaNiharika RawatKatja LakotaSnežna Sodin-ŠemrlAleš IgličIta JunkarMDPI AGarticlecardiovascular diseasemetallic stentshydrothermal treatmentnon-thermal plasma treatmentTiO<sub>2</sub>Biology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11858, p 11858 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiovascular disease metallic stents hydrothermal treatment non-thermal plasma treatment TiO<sub>2</sub> Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	cardiovascular disease metallic stents hydrothermal treatment non-thermal plasma treatment TiO<sub>2</sub> Biology (General) QH301-705.5 Chemistry QD1-999 Metka Benčina Niharika Rawat Katja Lakota Snežna Sodin-Šemrl Aleš Iglič Ita Junkar Bio-Performance of Hydrothermally and Plasma-Treated Titanium: The New Generation of Vascular Stents
description	The research presented herein follows an urgent global need for the development of novel surface engineering techniques that would allow the fabrication of next-generation cardiovascular stents, which would drastically reduce cardiovascular diseases (CVD). The combination of hydrothermal treatment (HT) and treatment with highly reactive oxygen plasma (P) allowed for the formation of an oxygen-rich nanostructured surface. The morphology, surface roughness, chemical composition and wettability of the newly prepared oxide layer on the Ti substrate were characterized by scanning electron microscopy (SEM) with energy-dispersive X-ray analysis (EDX), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS) and water contact angle (WCA) analysis. The alteration of surface characteristics influenced the material’s bio-performance; platelet aggregation and activation was reduced on surfaces treated by hydrothermal treatment, as well as after plasma treatment. Moreover, it was shown that surfaces treated by both treatment procedures (HT and P) promoted the adhesion and proliferation of vascular endothelial cells, while at the same time inhibiting the adhesion and proliferation of vascular smooth muscle cells. The combination of both techniques presents a novel approach for the fabrication of vascular implants, with superior characteristics.
format	article
author	Metka Benčina Niharika Rawat Katja Lakota Snežna Sodin-Šemrl Aleš Iglič Ita Junkar
author_facet	Metka Benčina Niharika Rawat Katja Lakota Snežna Sodin-Šemrl Aleš Iglič Ita Junkar
author_sort	Metka Benčina
title	Bio-Performance of Hydrothermally and Plasma-Treated Titanium: The New Generation of Vascular Stents
title_short	Bio-Performance of Hydrothermally and Plasma-Treated Titanium: The New Generation of Vascular Stents
title_full	Bio-Performance of Hydrothermally and Plasma-Treated Titanium: The New Generation of Vascular Stents
title_fullStr	Bio-Performance of Hydrothermally and Plasma-Treated Titanium: The New Generation of Vascular Stents
title_full_unstemmed	Bio-Performance of Hydrothermally and Plasma-Treated Titanium: The New Generation of Vascular Stents
title_sort	bio-performance of hydrothermally and plasma-treated titanium: the new generation of vascular stents
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/14b264dcdcd54b319f60be0e8c2abeff
work_keys_str_mv	AT metkabencina bioperformanceofhydrothermallyandplasmatreatedtitaniumthenewgenerationofvascularstents AT niharikarawat bioperformanceofhydrothermallyandplasmatreatedtitaniumthenewgenerationofvascularstents AT katjalakota bioperformanceofhydrothermallyandplasmatreatedtitaniumthenewgenerationofvascularstents AT sneznasodinsemrl bioperformanceofhydrothermallyandplasmatreatedtitaniumthenewgenerationofvascularstents AT alesiglic bioperformanceofhydrothermallyandplasmatreatedtitaniumthenewgenerationofvascularstents AT itajunkar bioperformanceofhydrothermallyandplasmatreatedtitaniumthenewgenerationofvascularstents
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Bio-Performance of Hydrothermally and Plasma-Treated Titanium: The New Generation of Vascular Stents

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