Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections

Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections

Pulmonary infections constitute a substantial health problem worldwide. Here the authors show that phagocytes similar to primitive macrophages can be generated from human induced pluripotent stem cells, by the use of industry-compatible, stirred-tank bioreactors, and applied as a cell-based therapy...

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Autores principales: Mania Ackermann, Henning Kempf, Miriam Hetzel, Christina Hesse, Anna Rafiei Hashtchin, Kerstin Brinkert, Juliane Wilhelmine Schott, Kathrin Haake, Mark Philipp Kühnel, Silke Glage, Constanca Figueiredo, Danny Jonigk, Katherina Sewald, Axel Schambach, Sabine Wronski, Thomas Moritz, Ulrich Martin, Robert Zweigerdt, Antje Munder, Nico Lachmann
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/14b2e8c926bf42f1a34ca9cec6a3b9d0
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spelling oai:doaj.org-article:14b2e8c926bf42f1a34ca9cec6a3b9d02021-12-02T17:32:49ZBioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections10.1038/s41467-018-07570-72041-1723https://doaj.org/article/14b2e8c926bf42f1a34ca9cec6a3b9d02018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07570-7https://doaj.org/toc/2041-1723Pulmonary infections constitute a substantial health problem worldwide. Here the authors show that phagocytes similar to primitive macrophages can be generated from human induced pluripotent stem cells, by the use of industry-compatible, stirred-tank bioreactors, and applied as a cell-based therapy to treat acute bacterial infections in mice.Mania AckermannHenning KempfMiriam HetzelChristina HesseAnna Rafiei HashtchinKerstin BrinkertJuliane Wilhelmine SchottKathrin HaakeMark Philipp KühnelSilke GlageConstanca FigueiredoDanny JonigkKatherina SewaldAxel SchambachSabine WronskiThomas MoritzUlrich MartinRobert ZweigerdtAntje MunderNico LachmannNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mania Ackermann
Henning Kempf
Miriam Hetzel
Christina Hesse
Anna Rafiei Hashtchin
Kerstin Brinkert
Juliane Wilhelmine Schott
Kathrin Haake
Mark Philipp Kühnel
Silke Glage
Constanca Figueiredo
Danny Jonigk
Katherina Sewald
Axel Schambach
Sabine Wronski
Thomas Moritz
Ulrich Martin
Robert Zweigerdt
Antje Munder
Nico Lachmann
Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections
description Pulmonary infections constitute a substantial health problem worldwide. Here the authors show that phagocytes similar to primitive macrophages can be generated from human induced pluripotent stem cells, by the use of industry-compatible, stirred-tank bioreactors, and applied as a cell-based therapy to treat acute bacterial infections in mice.
format article
author Mania Ackermann
Henning Kempf
Miriam Hetzel
Christina Hesse
Anna Rafiei Hashtchin
Kerstin Brinkert
Juliane Wilhelmine Schott
Kathrin Haake
Mark Philipp Kühnel
Silke Glage
Constanca Figueiredo
Danny Jonigk
Katherina Sewald
Axel Schambach
Sabine Wronski
Thomas Moritz
Ulrich Martin
Robert Zweigerdt
Antje Munder
Nico Lachmann
author_facet Mania Ackermann
Henning Kempf
Miriam Hetzel
Christina Hesse
Anna Rafiei Hashtchin
Kerstin Brinkert
Juliane Wilhelmine Schott
Kathrin Haake
Mark Philipp Kühnel
Silke Glage
Constanca Figueiredo
Danny Jonigk
Katherina Sewald
Axel Schambach
Sabine Wronski
Thomas Moritz
Ulrich Martin
Robert Zweigerdt
Antje Munder
Nico Lachmann
author_sort Mania Ackermann
title Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections
title_short Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections
title_full Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections
title_fullStr Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections
title_full_unstemmed Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections
title_sort bioreactor-based mass production of human ipsc-derived macrophages enables immunotherapies against bacterial airway infections
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/14b2e8c926bf42f1a34ca9cec6a3b9d0
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