Multiple spots of photodynamic therapy for the treatment of severe chronic central serous chorioretinopathy

George D Tsakonas, Athanasios I Kotsolis, Chrysanthi Koutsandrea, Ilias Georgalas, Dimitrios Papakonstantinou, Ioannis D LadasFirst Department of Ophthalmology, Medical School of Athens University, Athens, GreecePurpose: To evaluate the efficacy and safety of fluorescein angiography (FA)-guided phot...

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Autores principales:	Tsakonas GD, Kotsolis AI, Koutsandrea C, Georgalas I, Papaconstantinou D, Ladas ID
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/14b4e650afde4f8496a4c73cfad8d84b
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spelling	oai:doaj.org-article:14b4e650afde4f8496a4c73cfad8d84b2021-12-02T02:07:57ZMultiple spots of photodynamic therapy for the treatment of severe chronic central serous chorioretinopathy1177-54671177-5483https://doaj.org/article/14b4e650afde4f8496a4c73cfad8d84b2012-10-01T00:00:00Zhttp://www.dovepress.com/multiple-spots-of-photodynamic-therapy-for-the-treatment-of-severe-chr-a11216https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483George D Tsakonas, Athanasios I Kotsolis, Chrysanthi Koutsandrea, Ilias Georgalas, Dimitrios Papakonstantinou, Ioannis D LadasFirst Department of Ophthalmology, Medical School of Athens University, Athens, GreecePurpose: To evaluate the efficacy and safety of fluorescein angiography (FA)-guided photodynamic therapy (PDT) for the treatment of severe chronic central serous chorioretinopathy (CSC).Methods: Patients presenting with chronic CSC with multiple areas of retinal pigment epithelium decompensation, with or without focal leaks, were treated with FA-guided full-fluence PDT. Best-corrected visual acuity (BCVA), optical coherence tomography (OCT), FA, indocyanine green angiography, and fundus autofluorescence were used to determine functional and anatomic outcomes.Results: Twenty-one eyes (17 patients) were treated with PDT and followed for a median of 24 months (range, 12&ndash;73). In fourteen eyes (66.66%), two PDT spots were performed within the same session. In three eyes (14.28%), three PDT spots were performed, in two eyes (9.52%) four spots, and in two eyes (9.52%) five spots. In 17 eyes (80.95%), the leakage in FA and the subretinal fluid in OCT disappeared after only one session of PDT. In four eyes (19.05%), a second session &ndash; with only one spot &ndash; of PDT was required due to persistent or recurrent leakage and subfoveal SRF. Median BCVA improved significantly from 20/63 at baseline to 20/40 at 3 months (P = 0.0002) and 20/32 at 6 months (P &lt; 0.0001), and remained improved until the last examination (20/25, P &lt; 0.0001). Two patients complained of a transient central scotoma after the treatment.Conclusion: FA-guided full-fluence PDT with multiple PDT spots within the same session seems to be effective and safe for the treatment of chronic CSC cases with multiple areas of retinal pigment epithelium decompensation.Keywords: central serous chorioretinopathy, photodynamic therapyTsakonas GDKotsolis AIKoutsandrea CGeorgalas IPapaconstantinou DLadas IDDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 1639-1644 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Tsakonas GD Kotsolis AI Koutsandrea C Georgalas I Papaconstantinou D Ladas ID Multiple spots of photodynamic therapy for the treatment of severe chronic central serous chorioretinopathy
description	George D Tsakonas, Athanasios I Kotsolis, Chrysanthi Koutsandrea, Ilias Georgalas, Dimitrios Papakonstantinou, Ioannis D LadasFirst Department of Ophthalmology, Medical School of Athens University, Athens, GreecePurpose: To evaluate the efficacy and safety of fluorescein angiography (FA)-guided photodynamic therapy (PDT) for the treatment of severe chronic central serous chorioretinopathy (CSC).Methods: Patients presenting with chronic CSC with multiple areas of retinal pigment epithelium decompensation, with or without focal leaks, were treated with FA-guided full-fluence PDT. Best-corrected visual acuity (BCVA), optical coherence tomography (OCT), FA, indocyanine green angiography, and fundus autofluorescence were used to determine functional and anatomic outcomes.Results: Twenty-one eyes (17 patients) were treated with PDT and followed for a median of 24 months (range, 12&ndash;73). In fourteen eyes (66.66%), two PDT spots were performed within the same session. In three eyes (14.28%), three PDT spots were performed, in two eyes (9.52%) four spots, and in two eyes (9.52%) five spots. In 17 eyes (80.95%), the leakage in FA and the subretinal fluid in OCT disappeared after only one session of PDT. In four eyes (19.05%), a second session &ndash; with only one spot &ndash; of PDT was required due to persistent or recurrent leakage and subfoveal SRF. Median BCVA improved significantly from 20/63 at baseline to 20/40 at 3 months (P = 0.0002) and 20/32 at 6 months (P &lt; 0.0001), and remained improved until the last examination (20/25, P &lt; 0.0001). Two patients complained of a transient central scotoma after the treatment.Conclusion: FA-guided full-fluence PDT with multiple PDT spots within the same session seems to be effective and safe for the treatment of chronic CSC cases with multiple areas of retinal pigment epithelium decompensation.Keywords: central serous chorioretinopathy, photodynamic therapy
format	article
author	Tsakonas GD Kotsolis AI Koutsandrea C Georgalas I Papaconstantinou D Ladas ID
author_facet	Tsakonas GD Kotsolis AI Koutsandrea C Georgalas I Papaconstantinou D Ladas ID
author_sort	Tsakonas GD
title	Multiple spots of photodynamic therapy for the treatment of severe chronic central serous chorioretinopathy
title_short	Multiple spots of photodynamic therapy for the treatment of severe chronic central serous chorioretinopathy
title_full	Multiple spots of photodynamic therapy for the treatment of severe chronic central serous chorioretinopathy
title_fullStr	Multiple spots of photodynamic therapy for the treatment of severe chronic central serous chorioretinopathy
title_full_unstemmed	Multiple spots of photodynamic therapy for the treatment of severe chronic central serous chorioretinopathy
title_sort	multiple spots of photodynamic therapy for the treatment of severe chronic central serous chorioretinopathy
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/14b4e650afde4f8496a4c73cfad8d84b
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Multiple spots of photodynamic therapy for the treatment of severe chronic central serous chorioretinopathy

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