TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression

Insulin resistance is associated with development of type 2 diabetes. Here the authors show that TAZ interacts with c-Jun and Tead4, inducing expression of the insulin receptor substrate 1 (IRS1) leading to increased glucose uptake in muscle, and that its activity is counteracted by statin administr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jun-Ha Hwang, A Rum Kim, Kyung Min Kim, Jung Il Park, Ho Taek Oh, Sung A Moon, Mi Ran Byun, Hana Jeong, Hyo Kyung Kim, Michael B. Yaffe, Eun Sook Hwang, Jeong-Ho Hong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/14b73c8beec04ed68f0d0254de686c27
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:14b73c8beec04ed68f0d0254de686c27
record_format	dspace
spelling	oai:doaj.org-article:14b73c8beec04ed68f0d0254de686c272021-12-02T17:01:47ZTAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression10.1038/s41467-019-08287-x2041-1723https://doaj.org/article/14b73c8beec04ed68f0d0254de686c272019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08287-xhttps://doaj.org/toc/2041-1723Insulin resistance is associated with development of type 2 diabetes. Here the authors show that TAZ interacts with c-Jun and Tead4, inducing expression of the insulin receptor substrate 1 (IRS1) leading to increased glucose uptake in muscle, and that its activity is counteracted by statin administration.Jun-Ha HwangA Rum KimKyung Min KimJung Il ParkHo Taek OhSung A MoonMi Ran ByunHana JeongHyo Kyung KimMichael B. YaffeEun Sook HwangJeong-Ho HongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jun-Ha Hwang A Rum Kim Kyung Min Kim Jung Il Park Ho Taek Oh Sung A Moon Mi Ran Byun Hana Jeong Hyo Kyung Kim Michael B. Yaffe Eun Sook Hwang Jeong-Ho Hong TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression
description	Insulin resistance is associated with development of type 2 diabetes. Here the authors show that TAZ interacts with c-Jun and Tead4, inducing expression of the insulin receptor substrate 1 (IRS1) leading to increased glucose uptake in muscle, and that its activity is counteracted by statin administration.
format	article
author	Jun-Ha Hwang A Rum Kim Kyung Min Kim Jung Il Park Ho Taek Oh Sung A Moon Mi Ran Byun Hana Jeong Hyo Kyung Kim Michael B. Yaffe Eun Sook Hwang Jeong-Ho Hong
author_facet	Jun-Ha Hwang A Rum Kim Kyung Min Kim Jung Il Park Ho Taek Oh Sung A Moon Mi Ran Byun Hana Jeong Hyo Kyung Kim Michael B. Yaffe Eun Sook Hwang Jeong-Ho Hong
author_sort	Jun-Ha Hwang
title	TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression
title_short	TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression
title_full	TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression
title_fullStr	TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression
title_full_unstemmed	TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression
title_sort	taz couples hippo/wnt signalling and insulin sensitivity through irs1 expression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/14b73c8beec04ed68f0d0254de686c27
work_keys_str_mv	AT junhahwang tazcoupleshippowntsignallingandinsulinsensitivitythroughirs1expression AT arumkim tazcoupleshippowntsignallingandinsulinsensitivitythroughirs1expression AT kyungminkim tazcoupleshippowntsignallingandinsulinsensitivitythroughirs1expression AT jungilpark tazcoupleshippowntsignallingandinsulinsensitivitythroughirs1expression AT hotaekoh tazcoupleshippowntsignallingandinsulinsensitivitythroughirs1expression AT sungamoon tazcoupleshippowntsignallingandinsulinsensitivitythroughirs1expression AT miranbyun tazcoupleshippowntsignallingandinsulinsensitivitythroughirs1expression AT hanajeong tazcoupleshippowntsignallingandinsulinsensitivitythroughirs1expression AT hyokyungkim tazcoupleshippowntsignallingandinsulinsensitivitythroughirs1expression AT michaelbyaffe tazcoupleshippowntsignallingandinsulinsensitivitythroughirs1expression AT eunsookhwang tazcoupleshippowntsignallingandinsulinsensitivitythroughirs1expression AT jeonghohong tazcoupleshippowntsignallingandinsulinsensitivitythroughirs1expression
_version_	1718382010674708480

TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression

Ejemplares similares