Emerging Roles of Long Noncoding RNAs in Immuno-Oncology

Long noncoding RNAs (lncRNAs), defined as ncRNAs no longer than 200 nucleotides, play an important role in cancer development. Accumulating research on lncRNAs offers a compelling new aspect of genome modulation, in which they are involved in chromatin remodeling, transcriptional and post-transcript...

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Autores principales:	Xin Wang, Xu Wang, Midie Xu, Weiqi Sheng
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	lncRNA cancer tumor environment immune surveillance immuno-oncology Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/14b94cfa38c64a1e9ac32e5b0b56f012
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id	oai:doaj.org-article:14b94cfa38c64a1e9ac32e5b0b56f012
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spelling	oai:doaj.org-article:14b94cfa38c64a1e9ac32e5b0b56f0122021-12-01T00:58:02ZEmerging Roles of Long Noncoding RNAs in Immuno-Oncology2296-634X10.3389/fcell.2021.722904https://doaj.org/article/14b94cfa38c64a1e9ac32e5b0b56f0122021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.722904/fullhttps://doaj.org/toc/2296-634XLong noncoding RNAs (lncRNAs), defined as ncRNAs no longer than 200 nucleotides, play an important role in cancer development. Accumulating research on lncRNAs offers a compelling new aspect of genome modulation, in which they are involved in chromatin remodeling, transcriptional and post-transcriptional regulation, and cross-talk with other nucleic acids. Increasing evidence suggests that lncRNAs reshape the tumor microenvironment (TME), which accounts for tumor development and progression. At the same time, the insightful findings on lncRNAs in immune recognition and evasion in tumor-infiltrating immune cells raise concerns with regard to immuno-oncology. In this review, we describe the essential characteristics of lncRNAs, elucidate functions of immune components engaged in tumor surveillance, and present some instructive examples in this new area.Xin WangXin WangXu WangXu WangMidie XuMidie XuWeiqi ShengWeiqi ShengFrontiers Media S.A.articlelncRNAcancertumor environmentimmune surveillanceimmuno-oncologyBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lncRNA cancer tumor environment immune surveillance immuno-oncology Biology (General) QH301-705.5
spellingShingle	lncRNA cancer tumor environment immune surveillance immuno-oncology Biology (General) QH301-705.5 Xin Wang Xin Wang Xu Wang Xu Wang Midie Xu Midie Xu Weiqi Sheng Weiqi Sheng Emerging Roles of Long Noncoding RNAs in Immuno-Oncology
description	Long noncoding RNAs (lncRNAs), defined as ncRNAs no longer than 200 nucleotides, play an important role in cancer development. Accumulating research on lncRNAs offers a compelling new aspect of genome modulation, in which they are involved in chromatin remodeling, transcriptional and post-transcriptional regulation, and cross-talk with other nucleic acids. Increasing evidence suggests that lncRNAs reshape the tumor microenvironment (TME), which accounts for tumor development and progression. At the same time, the insightful findings on lncRNAs in immune recognition and evasion in tumor-infiltrating immune cells raise concerns with regard to immuno-oncology. In this review, we describe the essential characteristics of lncRNAs, elucidate functions of immune components engaged in tumor surveillance, and present some instructive examples in this new area.
format	article
author	Xin Wang Xin Wang Xu Wang Xu Wang Midie Xu Midie Xu Weiqi Sheng Weiqi Sheng
author_facet	Xin Wang Xin Wang Xu Wang Xu Wang Midie Xu Midie Xu Weiqi Sheng Weiqi Sheng
author_sort	Xin Wang
title	Emerging Roles of Long Noncoding RNAs in Immuno-Oncology
title_short	Emerging Roles of Long Noncoding RNAs in Immuno-Oncology
title_full	Emerging Roles of Long Noncoding RNAs in Immuno-Oncology
title_fullStr	Emerging Roles of Long Noncoding RNAs in Immuno-Oncology
title_full_unstemmed	Emerging Roles of Long Noncoding RNAs in Immuno-Oncology
title_sort	emerging roles of long noncoding rnas in immuno-oncology
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/14b94cfa38c64a1e9ac32e5b0b56f012
work_keys_str_mv	AT xinwang emergingrolesoflongnoncodingrnasinimmunooncology AT xinwang emergingrolesoflongnoncodingrnasinimmunooncology AT xuwang emergingrolesoflongnoncodingrnasinimmunooncology AT xuwang emergingrolesoflongnoncodingrnasinimmunooncology AT midiexu emergingrolesoflongnoncodingrnasinimmunooncology AT midiexu emergingrolesoflongnoncodingrnasinimmunooncology AT weiqisheng emergingrolesoflongnoncodingrnasinimmunooncology AT weiqisheng emergingrolesoflongnoncodingrnasinimmunooncology
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Emerging Roles of Long Noncoding RNAs in Immuno-Oncology

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