Protective effect of the HLA-DRB1*13:02 allele in Japanese rheumatoid arthritis patients.

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease. Certain HLA-DRB1 "shared-epitope" alleles are reported to be positively associated with increased RA susceptibility, whereas some of the other alleles may be negatively associated. However, studies on the latter are rare...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Shomi Oka, Hiroshi Furukawa, Aya Kawasaki, Kota Shimada, Shoji Sugii, Atsushi Hashimoto, Akiko Komiya, Naoshi Fukui, Satoshi Ito, Tadashi Nakamura, Koichiro Saisho, Masao Katayama, Shinichiro Tsunoda, Hajime Sano, Kiyoshi Migita, Akiko Suda, Shouhei Nagaoka, Naoyuki Tsuchiya, Shigeto Tohma
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
R
Q
Acceso en línea:https://doaj.org/article/14bced75e3a94961b82be185c94b0c68
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:14bced75e3a94961b82be185c94b0c68
record_format dspace
spelling oai:doaj.org-article:14bced75e3a94961b82be185c94b0c682021-11-18T08:16:38ZProtective effect of the HLA-DRB1*13:02 allele in Japanese rheumatoid arthritis patients.1932-620310.1371/journal.pone.0099453https://doaj.org/article/14bced75e3a94961b82be185c94b0c682014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24911054/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease. Certain HLA-DRB1 "shared-epitope" alleles are reported to be positively associated with increased RA susceptibility, whereas some of the other alleles may be negatively associated. However, studies on the latter are rare. Here, we focus on the protective effects of DRB1 alleles in Japanese RA patients in an association study. Relative predispositional effects (RPE) were analyzed by sequential elimination of carriers of each allele with the strongest association. The protective effects of DRB1 alleles were investigated in patients stratified according to whether they possessed anti-citrullinated peptide antibodies (ACPA). The DRB1*13:02 allele was found to be negatively associated with RA (P = 4.59×10(-10), corrected P (Pc) = 1.42×10(-8), odds ratio [OR] 0.42, 95% CI 0.32-0.55, P [RPE] = 1.27×10(-6)); the genotypes DRB1*04:05/*13:02 and *09:01/*13:02 were also negatively associated with RA. The protective effect of *13:02 was also present in ACPA-positive patients (P = 3.95×10(-8), Pc = 1.22×10(-6), OR 0.42, 95%CI 0.31-0.58) whereas *15:02 was negatively associated only with ACPA-negative RA (P = 8.87×10(-5), Pc = 0.0026, OR 0.26, 95%CI 0.12-0.56). Thus, this study identified a negative association of DRB1*13:02 with Japanese RA; our findings support the protective role of DRB1*13:02 in the pathogenesis of ACPA-positive RA.Shomi OkaHiroshi FurukawaAya KawasakiKota ShimadaShoji SugiiAtsushi HashimotoAkiko KomiyaNaoshi FukuiSatoshi ItoTadashi NakamuraKoichiro SaishoMasao KatayamaShinichiro TsunodaHajime SanoKiyoshi MigitaAkiko SudaShouhei NagaokaNaoyuki TsuchiyaShigeto TohmaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e99453 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Shomi Oka
Hiroshi Furukawa
Aya Kawasaki
Kota Shimada
Shoji Sugii
Atsushi Hashimoto
Akiko Komiya
Naoshi Fukui
Satoshi Ito
Tadashi Nakamura
Koichiro Saisho
Masao Katayama
Shinichiro Tsunoda
Hajime Sano
Kiyoshi Migita
Akiko Suda
Shouhei Nagaoka
Naoyuki Tsuchiya
Shigeto Tohma
Protective effect of the HLA-DRB1*13:02 allele in Japanese rheumatoid arthritis patients.
description Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease. Certain HLA-DRB1 "shared-epitope" alleles are reported to be positively associated with increased RA susceptibility, whereas some of the other alleles may be negatively associated. However, studies on the latter are rare. Here, we focus on the protective effects of DRB1 alleles in Japanese RA patients in an association study. Relative predispositional effects (RPE) were analyzed by sequential elimination of carriers of each allele with the strongest association. The protective effects of DRB1 alleles were investigated in patients stratified according to whether they possessed anti-citrullinated peptide antibodies (ACPA). The DRB1*13:02 allele was found to be negatively associated with RA (P = 4.59×10(-10), corrected P (Pc) = 1.42×10(-8), odds ratio [OR] 0.42, 95% CI 0.32-0.55, P [RPE] = 1.27×10(-6)); the genotypes DRB1*04:05/*13:02 and *09:01/*13:02 were also negatively associated with RA. The protective effect of *13:02 was also present in ACPA-positive patients (P = 3.95×10(-8), Pc = 1.22×10(-6), OR 0.42, 95%CI 0.31-0.58) whereas *15:02 was negatively associated only with ACPA-negative RA (P = 8.87×10(-5), Pc = 0.0026, OR 0.26, 95%CI 0.12-0.56). Thus, this study identified a negative association of DRB1*13:02 with Japanese RA; our findings support the protective role of DRB1*13:02 in the pathogenesis of ACPA-positive RA.
format article
author Shomi Oka
Hiroshi Furukawa
Aya Kawasaki
Kota Shimada
Shoji Sugii
Atsushi Hashimoto
Akiko Komiya
Naoshi Fukui
Satoshi Ito
Tadashi Nakamura
Koichiro Saisho
Masao Katayama
Shinichiro Tsunoda
Hajime Sano
Kiyoshi Migita
Akiko Suda
Shouhei Nagaoka
Naoyuki Tsuchiya
Shigeto Tohma
author_facet Shomi Oka
Hiroshi Furukawa
Aya Kawasaki
Kota Shimada
Shoji Sugii
Atsushi Hashimoto
Akiko Komiya
Naoshi Fukui
Satoshi Ito
Tadashi Nakamura
Koichiro Saisho
Masao Katayama
Shinichiro Tsunoda
Hajime Sano
Kiyoshi Migita
Akiko Suda
Shouhei Nagaoka
Naoyuki Tsuchiya
Shigeto Tohma
author_sort Shomi Oka
title Protective effect of the HLA-DRB1*13:02 allele in Japanese rheumatoid arthritis patients.
title_short Protective effect of the HLA-DRB1*13:02 allele in Japanese rheumatoid arthritis patients.
title_full Protective effect of the HLA-DRB1*13:02 allele in Japanese rheumatoid arthritis patients.
title_fullStr Protective effect of the HLA-DRB1*13:02 allele in Japanese rheumatoid arthritis patients.
title_full_unstemmed Protective effect of the HLA-DRB1*13:02 allele in Japanese rheumatoid arthritis patients.
title_sort protective effect of the hla-drb1*13:02 allele in japanese rheumatoid arthritis patients.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/14bced75e3a94961b82be185c94b0c68
work_keys_str_mv AT shomioka protectiveeffectofthehladrb11302alleleinjapaneserheumatoidarthritispatients
AT hiroshifurukawa protectiveeffectofthehladrb11302alleleinjapaneserheumatoidarthritispatients
AT ayakawasaki protectiveeffectofthehladrb11302alleleinjapaneserheumatoidarthritispatients
AT kotashimada protectiveeffectofthehladrb11302alleleinjapaneserheumatoidarthritispatients
AT shojisugii protectiveeffectofthehladrb11302alleleinjapaneserheumatoidarthritispatients
AT atsushihashimoto protectiveeffectofthehladrb11302alleleinjapaneserheumatoidarthritispatients
AT akikokomiya protectiveeffectofthehladrb11302alleleinjapaneserheumatoidarthritispatients
AT naoshifukui protectiveeffectofthehladrb11302alleleinjapaneserheumatoidarthritispatients
AT satoshiito protectiveeffectofthehladrb11302alleleinjapaneserheumatoidarthritispatients
AT tadashinakamura protectiveeffectofthehladrb11302alleleinjapaneserheumatoidarthritispatients
AT koichirosaisho protectiveeffectofthehladrb11302alleleinjapaneserheumatoidarthritispatients
AT masaokatayama protectiveeffectofthehladrb11302alleleinjapaneserheumatoidarthritispatients
AT shinichirotsunoda protectiveeffectofthehladrb11302alleleinjapaneserheumatoidarthritispatients
AT hajimesano protectiveeffectofthehladrb11302alleleinjapaneserheumatoidarthritispatients
AT kiyoshimigita protectiveeffectofthehladrb11302alleleinjapaneserheumatoidarthritispatients
AT akikosuda protectiveeffectofthehladrb11302alleleinjapaneserheumatoidarthritispatients
AT shouheinagaoka protectiveeffectofthehladrb11302alleleinjapaneserheumatoidarthritispatients
AT naoyukitsuchiya protectiveeffectofthehladrb11302alleleinjapaneserheumatoidarthritispatients
AT shigetotohma protectiveeffectofthehladrb11302alleleinjapaneserheumatoidarthritispatients
_version_ 1718421968458350592