Review of anticancer potentials and structure-activity relationships (SAR) of rhodanine derivatives

Rhodanine has been recognized as a privileged scaffold in medicinal chemistry due to its well-known ability to demonstrate a broad range of biological activities. The possibility of structural diversification has contributed to the significance of rhodanine structure in effective drug discovery and...

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Autores principales:	Lim Ju Yin, Ahmad Khairul Daniel bin Ahmad Kamar, Gan Tjin Fung, Chin Tze Liang, Vasudeva Rao Avupati
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Rhodanine 2-thioxo-4-thiazolidinone Structure-Activity Relationships (SAR) Cytotoxic Cancer Anticancer Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/14bd3083d5704897befbf0c9458f3ddb
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id	oai:doaj.org-article:14bd3083d5704897befbf0c9458f3ddb
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spelling	oai:doaj.org-article:14bd3083d5704897befbf0c9458f3ddb2021-11-14T04:30:31ZReview of anticancer potentials and structure-activity relationships (SAR) of rhodanine derivatives0753-332210.1016/j.biopha.2021.112406https://doaj.org/article/14bd3083d5704897befbf0c9458f3ddb2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221011926https://doaj.org/toc/0753-3322Rhodanine has been recognized as a privileged scaffold in medicinal chemistry due to its well-known ability to demonstrate a broad range of biological activities. The possibility of structural diversification has contributed to the significance of rhodanine structure in effective drug discovery and design. Many studies have confirmed the potential of rhodanine-derived compounds in the treatment of different types of cancer through the apoptosis induction mechanism. Furthermore, most of the rhodanine derivatives exhibited remarkable anticancer activity in the micromolar range while causing negligible cytotoxicity to normal cells. This review critically describes the anticancer activity profile of reported rhodanine compounds and the structure-activity relationships (SAR) to highlight the value of rhodanine as the core structure for future cancer drug development as well as to assist the researchers in rational drug design.Lim Ju YinAhmad Khairul Daniel bin Ahmad KamarGan Tjin FungChin Tze LiangVasudeva Rao AvupatiElsevierarticleRhodanine2-thioxo-4-thiazolidinoneStructure-Activity Relationships (SAR)CytotoxicCancerAnticancerTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112406- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Rhodanine 2-thioxo-4-thiazolidinone Structure-Activity Relationships (SAR) Cytotoxic Cancer Anticancer Therapeutics. Pharmacology RM1-950
spellingShingle	Rhodanine 2-thioxo-4-thiazolidinone Structure-Activity Relationships (SAR) Cytotoxic Cancer Anticancer Therapeutics. Pharmacology RM1-950 Lim Ju Yin Ahmad Khairul Daniel bin Ahmad Kamar Gan Tjin Fung Chin Tze Liang Vasudeva Rao Avupati Review of anticancer potentials and structure-activity relationships (SAR) of rhodanine derivatives
description	Rhodanine has been recognized as a privileged scaffold in medicinal chemistry due to its well-known ability to demonstrate a broad range of biological activities. The possibility of structural diversification has contributed to the significance of rhodanine structure in effective drug discovery and design. Many studies have confirmed the potential of rhodanine-derived compounds in the treatment of different types of cancer through the apoptosis induction mechanism. Furthermore, most of the rhodanine derivatives exhibited remarkable anticancer activity in the micromolar range while causing negligible cytotoxicity to normal cells. This review critically describes the anticancer activity profile of reported rhodanine compounds and the structure-activity relationships (SAR) to highlight the value of rhodanine as the core structure for future cancer drug development as well as to assist the researchers in rational drug design.
format	article
author	Lim Ju Yin Ahmad Khairul Daniel bin Ahmad Kamar Gan Tjin Fung Chin Tze Liang Vasudeva Rao Avupati
author_facet	Lim Ju Yin Ahmad Khairul Daniel bin Ahmad Kamar Gan Tjin Fung Chin Tze Liang Vasudeva Rao Avupati
author_sort	Lim Ju Yin
title	Review of anticancer potentials and structure-activity relationships (SAR) of rhodanine derivatives
title_short	Review of anticancer potentials and structure-activity relationships (SAR) of rhodanine derivatives
title_full	Review of anticancer potentials and structure-activity relationships (SAR) of rhodanine derivatives
title_fullStr	Review of anticancer potentials and structure-activity relationships (SAR) of rhodanine derivatives
title_full_unstemmed	Review of anticancer potentials and structure-activity relationships (SAR) of rhodanine derivatives
title_sort	review of anticancer potentials and structure-activity relationships (sar) of rhodanine derivatives
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/14bd3083d5704897befbf0c9458f3ddb
work_keys_str_mv	AT limjuyin reviewofanticancerpotentialsandstructureactivityrelationshipssarofrhodaninederivatives AT ahmadkhairuldanielbinahmadkamar reviewofanticancerpotentialsandstructureactivityrelationshipssarofrhodaninederivatives AT gantjinfung reviewofanticancerpotentialsandstructureactivityrelationshipssarofrhodaninederivatives AT chintzeliang reviewofanticancerpotentialsandstructureactivityrelationshipssarofrhodaninederivatives AT vasudevaraoavupati reviewofanticancerpotentialsandstructureactivityrelationshipssarofrhodaninederivatives
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Review of anticancer potentials and structure-activity relationships (SAR) of rhodanine derivatives

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