Tollip or not Tollip: what are the evolving questions behind it?

Tollip plays an important role in the interleukin-1 receptor IL-1R and Toll pathways. As a modulator of the immune pathway, it indirectly controls the amount of antimicrobial peptides. This could indicate a vital step in maintaining animal immune systems and preventing infection. Evolutionary questi...

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Autores principales:	Denis Prudencio Luiz, Célio Dias Santos Júnior, Ana Maria Bonetti, Malcom Antônio Manfredi Brandeburgo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/14be2e01f242487fbcc6eefd7f50a0bc
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spelling	oai:doaj.org-article:14be2e01f242487fbcc6eefd7f50a0bc2021-11-18T08:19:16ZTollip or not Tollip: what are the evolving questions behind it?1932-620310.1371/journal.pone.0097219https://doaj.org/article/14be2e01f242487fbcc6eefd7f50a0bc2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24828816/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Tollip plays an important role in the interleukin-1 receptor IL-1R and Toll pathways. As a modulator of the immune pathway, it indirectly controls the amount of antimicrobial peptides. This could indicate a vital step in maintaining animal immune systems and preventing infection. Evolutionary questions are crucial to understanding the conservation and functioning of the biochemical pathways like the Tollip-mediated one. Through an analysis of 36 sequences of the Tollip protein from different animal taxa, downloaded from Kyoto Encyclopedia of Genes and Genomes (KEGG) databank, we inferred diverse evolutionary parameters, such as molecular selection and structure conservation, by analyzing residue by residue, beyond the canonical parameters to this type of study, as maximum likelihood trees. We found that Tollip presented different trends in its evolving history. In primates, the protein is becoming more unstable, just the opposite is observed in the arthropod group. The most interesting finding was the concentration of positively selected residues at amino terminal ends. Some observed topological incongruences in maximum likelihood trees of complete and curated Tollip data sets could be explained through horizontal transfers, evidenced by recombination detection. These results suggest that there is more to be researched and understood about this protein.Denis Prudencio LuizCélio Dias Santos JúniorAna Maria BonettiMalcom Antônio Manfredi BrandeburgoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e97219 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Denis Prudencio Luiz Célio Dias Santos Júnior Ana Maria Bonetti Malcom Antônio Manfredi Brandeburgo Tollip or not Tollip: what are the evolving questions behind it?
description	Tollip plays an important role in the interleukin-1 receptor IL-1R and Toll pathways. As a modulator of the immune pathway, it indirectly controls the amount of antimicrobial peptides. This could indicate a vital step in maintaining animal immune systems and preventing infection. Evolutionary questions are crucial to understanding the conservation and functioning of the biochemical pathways like the Tollip-mediated one. Through an analysis of 36 sequences of the Tollip protein from different animal taxa, downloaded from Kyoto Encyclopedia of Genes and Genomes (KEGG) databank, we inferred diverse evolutionary parameters, such as molecular selection and structure conservation, by analyzing residue by residue, beyond the canonical parameters to this type of study, as maximum likelihood trees. We found that Tollip presented different trends in its evolving history. In primates, the protein is becoming more unstable, just the opposite is observed in the arthropod group. The most interesting finding was the concentration of positively selected residues at amino terminal ends. Some observed topological incongruences in maximum likelihood trees of complete and curated Tollip data sets could be explained through horizontal transfers, evidenced by recombination detection. These results suggest that there is more to be researched and understood about this protein.
format	article
author	Denis Prudencio Luiz Célio Dias Santos Júnior Ana Maria Bonetti Malcom Antônio Manfredi Brandeburgo
author_facet	Denis Prudencio Luiz Célio Dias Santos Júnior Ana Maria Bonetti Malcom Antônio Manfredi Brandeburgo
author_sort	Denis Prudencio Luiz
title	Tollip or not Tollip: what are the evolving questions behind it?
title_short	Tollip or not Tollip: what are the evolving questions behind it?
title_full	Tollip or not Tollip: what are the evolving questions behind it?
title_fullStr	Tollip or not Tollip: what are the evolving questions behind it?
title_full_unstemmed	Tollip or not Tollip: what are the evolving questions behind it?
title_sort	tollip or not tollip: what are the evolving questions behind it?
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/14be2e01f242487fbcc6eefd7f50a0bc
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Tollip or not Tollip: what are the evolving questions behind it?

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