IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population
Patients who survive sepsis are at increased risk of infection owing to long-term immunosuppression that is associated with an increase in Treg cell numbers. Here the authors show expansion of the Treg cell population in sepsis mice is driven by IL-33-induced ILC2 activation of IL-10 production by m...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/14c052279c2943bbbeef427db07d64ab |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:14c052279c2943bbbeef427db07d64ab |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:14c052279c2943bbbeef427db07d64ab2021-12-02T14:42:42ZIL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population10.1038/ncomms149192041-1723https://doaj.org/article/14c052279c2943bbbeef427db07d64ab2017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14919https://doaj.org/toc/2041-1723Patients who survive sepsis are at increased risk of infection owing to long-term immunosuppression that is associated with an increase in Treg cell numbers. Here the authors show expansion of the Treg cell population in sepsis mice is driven by IL-33-induced ILC2 activation of IL-10 production by macrophages.Daniele C. NascimentoPaulo H. MeloAnnie R. PiñerosRaphael G. FerreiraDavid F. ColónPaula B. DonateFernanda V. CastanheiraAline GozziPaula G. CzaikoskiWanda NiedbalaMarcos C. BorgesDario S. ZamboniFoo Y. LiewFernando Q. CunhaJose C. Alves-FilhoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Daniele C. Nascimento Paulo H. Melo Annie R. Piñeros Raphael G. Ferreira David F. Colón Paula B. Donate Fernanda V. Castanheira Aline Gozzi Paula G. Czaikoski Wanda Niedbala Marcos C. Borges Dario S. Zamboni Foo Y. Liew Fernando Q. Cunha Jose C. Alves-Filho IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population |
| description |
Patients who survive sepsis are at increased risk of infection owing to long-term immunosuppression that is associated with an increase in Treg cell numbers. Here the authors show expansion of the Treg cell population in sepsis mice is driven by IL-33-induced ILC2 activation of IL-10 production by macrophages. |
| format |
article |
| author |
Daniele C. Nascimento Paulo H. Melo Annie R. Piñeros Raphael G. Ferreira David F. Colón Paula B. Donate Fernanda V. Castanheira Aline Gozzi Paula G. Czaikoski Wanda Niedbala Marcos C. Borges Dario S. Zamboni Foo Y. Liew Fernando Q. Cunha Jose C. Alves-Filho |
| author_facet |
Daniele C. Nascimento Paulo H. Melo Annie R. Piñeros Raphael G. Ferreira David F. Colón Paula B. Donate Fernanda V. Castanheira Aline Gozzi Paula G. Czaikoski Wanda Niedbala Marcos C. Borges Dario S. Zamboni Foo Y. Liew Fernando Q. Cunha Jose C. Alves-Filho |
| author_sort |
Daniele C. Nascimento |
| title |
IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population |
| title_short |
IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population |
| title_full |
IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population |
| title_fullStr |
IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population |
| title_full_unstemmed |
IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population |
| title_sort |
il-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory t cell population |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/14c052279c2943bbbeef427db07d64ab |
| work_keys_str_mv |
AT danielecnascimento il33contributestosepsisinducedlongtermimmunosuppressionbyexpandingtheregulatorytcellpopulation AT paulohmelo il33contributestosepsisinducedlongtermimmunosuppressionbyexpandingtheregulatorytcellpopulation AT annierpineros il33contributestosepsisinducedlongtermimmunosuppressionbyexpandingtheregulatorytcellpopulation AT raphaelgferreira il33contributestosepsisinducedlongtermimmunosuppressionbyexpandingtheregulatorytcellpopulation AT davidfcolon il33contributestosepsisinducedlongtermimmunosuppressionbyexpandingtheregulatorytcellpopulation AT paulabdonate il33contributestosepsisinducedlongtermimmunosuppressionbyexpandingtheregulatorytcellpopulation AT fernandavcastanheira il33contributestosepsisinducedlongtermimmunosuppressionbyexpandingtheregulatorytcellpopulation AT alinegozzi il33contributestosepsisinducedlongtermimmunosuppressionbyexpandingtheregulatorytcellpopulation AT paulagczaikoski il33contributestosepsisinducedlongtermimmunosuppressionbyexpandingtheregulatorytcellpopulation AT wandaniedbala il33contributestosepsisinducedlongtermimmunosuppressionbyexpandingtheregulatorytcellpopulation AT marcoscborges il33contributestosepsisinducedlongtermimmunosuppressionbyexpandingtheregulatorytcellpopulation AT darioszamboni il33contributestosepsisinducedlongtermimmunosuppressionbyexpandingtheregulatorytcellpopulation AT fooyliew il33contributestosepsisinducedlongtermimmunosuppressionbyexpandingtheregulatorytcellpopulation AT fernandoqcunha il33contributestosepsisinducedlongtermimmunosuppressionbyexpandingtheregulatorytcellpopulation AT josecalvesfilho il33contributestosepsisinducedlongtermimmunosuppressionbyexpandingtheregulatorytcellpopulation |
| _version_ |
1718389614164574208 |