Insulin-like Growth Factor 1 in relation to future hearing impairment: findings from the English Longitudinal Study of Ageing

Abstract Insulin-like Growth Factor 1 (IGF-1) is associated with cardiovascular disease, itself a risk factor for hearing impairment, and, in animal studies, molecular evidence suggests a role for IGF-1 in hearing function. However, the link between IGF-1 and the occurrence of hearing impairment is...

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Autores principales:	Camille Lassale, G. David Batty, Andrew Steptoe, Paola Zaninotto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/14c185b4ffdf47d18a782485a553d411
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spelling	oai:doaj.org-article:14c185b4ffdf47d18a782485a553d4112021-12-02T11:40:14ZInsulin-like Growth Factor 1 in relation to future hearing impairment: findings from the English Longitudinal Study of Ageing10.1038/s41598-017-04526-72045-2322https://doaj.org/article/14c185b4ffdf47d18a782485a553d4112017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04526-7https://doaj.org/toc/2045-2322Abstract Insulin-like Growth Factor 1 (IGF-1) is associated with cardiovascular disease, itself a risk factor for hearing impairment, and, in animal studies, molecular evidence suggests a role for IGF-1 in hearing function. However, the link between IGF-1 and the occurrence of hearing impairment is untested in population-based studies of humans. A total of 4390 participants aged ≥50 y (mean [SD] age 64.2 [8.0] years at baseline, 55% women) from the English Longitudinal Study of Ageing provided serum levels of IGF-1 in 2008 and again in 2012. Hearing acuity was assessed by an objective hearing test (HearCheck handheld device) in 2014 when the prevalence was 38.2%. In the full cohort, IGF-1 was not associated with subsequent hearing impairment (OR5nmol/L increase; 95% CI: 1.01; 0.94, 1.09). However, this relationship appeared to differ by age (p-value for interaction = 0.03). Thus, in younger participants (aged 50–60 y, n = 1400), IGF-1 was associated with lower odds of hearing impairment (0.86; 0.73, 1.00) after adjustment for a range of potential confounders. Among people ≥60 y (n = 2990) there was a non-significant ‘J’-shaped association. Our observational evidence that higher levels of IGF-1 appeared to confer some protection against hearing impairment in some older adults warrants replication in other prospective cohort studies.Camille LassaleG. David BattyAndrew SteptoePaola ZaninottoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Camille Lassale G. David Batty Andrew Steptoe Paola Zaninotto Insulin-like Growth Factor 1 in relation to future hearing impairment: findings from the English Longitudinal Study of Ageing
description	Abstract Insulin-like Growth Factor 1 (IGF-1) is associated with cardiovascular disease, itself a risk factor for hearing impairment, and, in animal studies, molecular evidence suggests a role for IGF-1 in hearing function. However, the link between IGF-1 and the occurrence of hearing impairment is untested in population-based studies of humans. A total of 4390 participants aged ≥50 y (mean [SD] age 64.2 [8.0] years at baseline, 55% women) from the English Longitudinal Study of Ageing provided serum levels of IGF-1 in 2008 and again in 2012. Hearing acuity was assessed by an objective hearing test (HearCheck handheld device) in 2014 when the prevalence was 38.2%. In the full cohort, IGF-1 was not associated with subsequent hearing impairment (OR5nmol/L increase; 95% CI: 1.01; 0.94, 1.09). However, this relationship appeared to differ by age (p-value for interaction = 0.03). Thus, in younger participants (aged 50–60 y, n = 1400), IGF-1 was associated with lower odds of hearing impairment (0.86; 0.73, 1.00) after adjustment for a range of potential confounders. Among people ≥60 y (n = 2990) there was a non-significant ‘J’-shaped association. Our observational evidence that higher levels of IGF-1 appeared to confer some protection against hearing impairment in some older adults warrants replication in other prospective cohort studies.
format	article
author	Camille Lassale G. David Batty Andrew Steptoe Paola Zaninotto
author_facet	Camille Lassale G. David Batty Andrew Steptoe Paola Zaninotto
author_sort	Camille Lassale
title	Insulin-like Growth Factor 1 in relation to future hearing impairment: findings from the English Longitudinal Study of Ageing
title_short	Insulin-like Growth Factor 1 in relation to future hearing impairment: findings from the English Longitudinal Study of Ageing
title_full	Insulin-like Growth Factor 1 in relation to future hearing impairment: findings from the English Longitudinal Study of Ageing
title_fullStr	Insulin-like Growth Factor 1 in relation to future hearing impairment: findings from the English Longitudinal Study of Ageing
title_full_unstemmed	Insulin-like Growth Factor 1 in relation to future hearing impairment: findings from the English Longitudinal Study of Ageing
title_sort	insulin-like growth factor 1 in relation to future hearing impairment: findings from the english longitudinal study of ageing
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/14c185b4ffdf47d18a782485a553d411
work_keys_str_mv	AT camillelassale insulinlikegrowthfactor1inrelationtofuturehearingimpairmentfindingsfromtheenglishlongitudinalstudyofageing AT gdavidbatty insulinlikegrowthfactor1inrelationtofuturehearingimpairmentfindingsfromtheenglishlongitudinalstudyofageing AT andrewsteptoe insulinlikegrowthfactor1inrelationtofuturehearingimpairmentfindingsfromtheenglishlongitudinalstudyofageing AT paolazaninotto insulinlikegrowthfactor1inrelationtofuturehearingimpairmentfindingsfromtheenglishlongitudinalstudyofageing
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Insulin-like Growth Factor 1 in relation to future hearing impairment: findings from the English Longitudinal Study of Ageing

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