Analysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V1

Abstract Quantitatively comparing brain-wide connectivity of different types of neuron is of vital importance in understanding the function of the mammalian cortex. Here we have designed an analytical approach to examine and compare datasets from hierarchical segmentation ontologies, and applied it...

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Autores principales:	Alexander P. Y. Brown, Lee Cossell, Molly Strom, Adam L. Tyson, Mateo Vélez-Fort, Troy W. Margrie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/14c2930f1e24415b9b0fc26437534211
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spelling	oai:doaj.org-article:14c2930f1e24415b9b0fc264375342112021-12-02T13:30:51ZAnalysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V110.1038/s41598-021-82353-72045-2322https://doaj.org/article/14c2930f1e24415b9b0fc264375342112021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82353-7https://doaj.org/toc/2045-2322Abstract Quantitatively comparing brain-wide connectivity of different types of neuron is of vital importance in understanding the function of the mammalian cortex. Here we have designed an analytical approach to examine and compare datasets from hierarchical segmentation ontologies, and applied it to long-range presynaptic connectivity onto excitatory and inhibitory neurons, mainly located in layer 2/3 (L2/3), of mouse primary visual cortex (V1). We find that the origins of long-range connections onto these two general cell classes—as well as their proportions—are quite similar, in contrast to the inputs on to a cell type in L6. These anatomical data suggest that distal inputs received by the general excitatory and inhibitory classes of neuron in L2/3 overlap considerably.Alexander P. Y. BrownLee CossellMolly StromAdam L. TysonMateo Vélez-FortTroy W. MargrieNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexander P. Y. Brown Lee Cossell Molly Strom Adam L. Tyson Mateo Vélez-Fort Troy W. Margrie Analysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V1
description	Abstract Quantitatively comparing brain-wide connectivity of different types of neuron is of vital importance in understanding the function of the mammalian cortex. Here we have designed an analytical approach to examine and compare datasets from hierarchical segmentation ontologies, and applied it to long-range presynaptic connectivity onto excitatory and inhibitory neurons, mainly located in layer 2/3 (L2/3), of mouse primary visual cortex (V1). We find that the origins of long-range connections onto these two general cell classes—as well as their proportions—are quite similar, in contrast to the inputs on to a cell type in L6. These anatomical data suggest that distal inputs received by the general excitatory and inhibitory classes of neuron in L2/3 overlap considerably.
format	article
author	Alexander P. Y. Brown Lee Cossell Molly Strom Adam L. Tyson Mateo Vélez-Fort Troy W. Margrie
author_facet	Alexander P. Y. Brown Lee Cossell Molly Strom Adam L. Tyson Mateo Vélez-Fort Troy W. Margrie
author_sort	Alexander P. Y. Brown
title	Analysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V1
title_short	Analysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V1
title_full	Analysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V1
title_fullStr	Analysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V1
title_full_unstemmed	Analysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V1
title_sort	analysis of segmentation ontology reveals the similarities and differences in connectivity onto l2/3 neurons in mouse v1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/14c2930f1e24415b9b0fc26437534211
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Analysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V1

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