Clinical Value of C-Reactive Protein/Platelet Ratio in Neonatal Sepsis: A Cross-Sectional Study

Xiaojuan Li,1 Tiewei Li,1 Jingjing Wang,2 Yichuan Feng,1 Chong Ren,1 Zhe Xu,1 Junmei Yang,1 Qian Zhang,3 Caiyan An4 1Zhengzhou Key Laboratory of Children’s Infection and Immunity, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, Zhengz...

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Autores principales:	Li X, Li T, Wang J, Feng Y, Ren C, Xu Z, Yang J, Zhang Q, An C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	c-reactive protein-to-platelet ratio neonatal sepsis risk factor severe sepsis Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/14c4e0ccb2f2486ebc2a58a71a2037d5
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spelling	oai:doaj.org-article:14c4e0ccb2f2486ebc2a58a71a2037d52021-12-02T19:18:34ZClinical Value of C-Reactive Protein/Platelet Ratio in Neonatal Sepsis: A Cross-Sectional Study1178-7031https://doaj.org/article/14c4e0ccb2f2486ebc2a58a71a2037d52021-10-01T00:00:00Zhttps://www.dovepress.com/clinical-value-of-c-reactive-proteinplatelet-ratio-in-neonatal-sepsis--peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Xiaojuan Li,1 Tiewei Li,1 Jingjing Wang,2 Yichuan Feng,1 Chong Ren,1 Zhe Xu,1 Junmei Yang,1 Qian Zhang,3 Caiyan An4 1Zhengzhou Key Laboratory of Children’s Infection and Immunity, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, Zhengzhou, 450018, People’s Republic of China; 2Department of Neonatology, Ordos Central Hospital, Ordos, 01700, People’s Republic of China; 3The Center for New Drug Safety Evaluation and Research, Inner Mongolia Medical University, Hohhot, People’s Republic of China; 4Clinical Research Center of the Affiliated Hospital, Inner Mongolia Medical University, Hohhot, People’s Republic of ChinaCorrespondence: Tiewei LiZhengzhou Key Laboratory of Children’s Infection and Immunity, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, 33M Waihuan East Road, Longhu, Zhengzhou, 450018, People’s Republic of ChinaTel +8637185515779Email litieweind@63.comJingjing WangOrdos Central Hospital, No. 23, Yijinholo Street, Dongsheng District, Ordos, 017000, People’s Republic of ChinaTel +86-15924482258Email onlyonecoco@163.comPurpose: C-reactive protein (CRP) level and platelet (PLT) count have been demonstrated to be independent risk factor for neonatal sepsis. However, no data is currently available in regarding the association between CRP-to-PLT ratio (CPR) and neonatal sepsis.Methods: A total of 1048 neonates with suspected sepsis were enrolled in this study. Complete clinical and laboratory data were collected. CPR was calculated as CRP (mg/L)/PLT (107 cells/L). Multivariate logistic regression analysis was performed to identify the potential independent risk factors of neonatal sepsis. Receiver operating characteristic (ROC) curve analysis was used to evaluate the prediction accuracy of CPR in predicting neonatal sepsis.Results: Neonates with sepsis had a higher CPR. CPR also showed a gradual increase in the infection, mild sepsis and severe sepsis groups. Multivariate analysis revealed that CPR was a significant independent predictor of the presence of neonatal sepsis (odds ratio [OR], 1.015; 95% confidence interval [CI], 1.008– 1.022, P < 0.001) and severe sepsis (OR, 1.002; 95% CI, 1.000– 1.003, P = 0.007). ROC curve revealed showed that CPR had a well-discriminatory power in predicting sepsis (area under curve [AUC], 0.68; 95% CI, 0.65– 0.72, P < 0.001) and severe sepsis (AUC, 0.68; 95% CI, 0.65– 0.72, P < 0.001).Conclusion: The present study demonstrated that a higher CPR is an independent predictor of the presence and severity of neonatal sepsis.Keywords: C-reactive protein-to-platelet ratio, neonatal sepsis, risk factor, severe sepsisLi XLi TWang JFeng YRen CXu ZYang JZhang QAn CDove Medical Pressarticlec-reactive protein-to-platelet rationeonatal sepsisrisk factorsevere sepsisPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 5123-5129 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	c-reactive protein-to-platelet ratio neonatal sepsis risk factor severe sepsis Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	c-reactive protein-to-platelet ratio neonatal sepsis risk factor severe sepsis Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Li X Li T Wang J Feng Y Ren C Xu Z Yang J Zhang Q An C Clinical Value of C-Reactive Protein/Platelet Ratio in Neonatal Sepsis: A Cross-Sectional Study
description	Xiaojuan Li,1 Tiewei Li,1 Jingjing Wang,2 Yichuan Feng,1 Chong Ren,1 Zhe Xu,1 Junmei Yang,1 Qian Zhang,3 Caiyan An4 1Zhengzhou Key Laboratory of Children’s Infection and Immunity, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, Zhengzhou, 450018, People’s Republic of China; 2Department of Neonatology, Ordos Central Hospital, Ordos, 01700, People’s Republic of China; 3The Center for New Drug Safety Evaluation and Research, Inner Mongolia Medical University, Hohhot, People’s Republic of China; 4Clinical Research Center of the Affiliated Hospital, Inner Mongolia Medical University, Hohhot, People’s Republic of ChinaCorrespondence: Tiewei LiZhengzhou Key Laboratory of Children’s Infection and Immunity, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, 33M Waihuan East Road, Longhu, Zhengzhou, 450018, People’s Republic of ChinaTel +8637185515779Email litieweind@63.comJingjing WangOrdos Central Hospital, No. 23, Yijinholo Street, Dongsheng District, Ordos, 017000, People’s Republic of ChinaTel +86-15924482258Email onlyonecoco@163.comPurpose: C-reactive protein (CRP) level and platelet (PLT) count have been demonstrated to be independent risk factor for neonatal sepsis. However, no data is currently available in regarding the association between CRP-to-PLT ratio (CPR) and neonatal sepsis.Methods: A total of 1048 neonates with suspected sepsis were enrolled in this study. Complete clinical and laboratory data were collected. CPR was calculated as CRP (mg/L)/PLT (107 cells/L). Multivariate logistic regression analysis was performed to identify the potential independent risk factors of neonatal sepsis. Receiver operating characteristic (ROC) curve analysis was used to evaluate the prediction accuracy of CPR in predicting neonatal sepsis.Results: Neonates with sepsis had a higher CPR. CPR also showed a gradual increase in the infection, mild sepsis and severe sepsis groups. Multivariate analysis revealed that CPR was a significant independent predictor of the presence of neonatal sepsis (odds ratio [OR], 1.015; 95% confidence interval [CI], 1.008– 1.022, P < 0.001) and severe sepsis (OR, 1.002; 95% CI, 1.000– 1.003, P = 0.007). ROC curve revealed showed that CPR had a well-discriminatory power in predicting sepsis (area under curve [AUC], 0.68; 95% CI, 0.65– 0.72, P < 0.001) and severe sepsis (AUC, 0.68; 95% CI, 0.65– 0.72, P < 0.001).Conclusion: The present study demonstrated that a higher CPR is an independent predictor of the presence and severity of neonatal sepsis.Keywords: C-reactive protein-to-platelet ratio, neonatal sepsis, risk factor, severe sepsis
format	article
author	Li X Li T Wang J Feng Y Ren C Xu Z Yang J Zhang Q An C
author_facet	Li X Li T Wang J Feng Y Ren C Xu Z Yang J Zhang Q An C
author_sort	Li X
title	Clinical Value of C-Reactive Protein/Platelet Ratio in Neonatal Sepsis: A Cross-Sectional Study
title_short	Clinical Value of C-Reactive Protein/Platelet Ratio in Neonatal Sepsis: A Cross-Sectional Study
title_full	Clinical Value of C-Reactive Protein/Platelet Ratio in Neonatal Sepsis: A Cross-Sectional Study
title_fullStr	Clinical Value of C-Reactive Protein/Platelet Ratio in Neonatal Sepsis: A Cross-Sectional Study
title_full_unstemmed	Clinical Value of C-Reactive Protein/Platelet Ratio in Neonatal Sepsis: A Cross-Sectional Study
title_sort	clinical value of c-reactive protein/platelet ratio in neonatal sepsis: a cross-sectional study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/14c4e0ccb2f2486ebc2a58a71a2037d5
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Clinical Value of C-Reactive Protein/Platelet Ratio in Neonatal Sepsis: A Cross-Sectional Study

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