Functional State of the Thyroid Gland and Lipid Peroxidation and Antioxidant Protection System in Women of Reproductive Age with Chronic Form of Parenteral Viral Hepatitis

Background. Chronic viral hepatitis is a complex global problem and is still far from being solved. Many researchers point out influence of viral hepatitis on the reproductive system of women.Aim. To identify features of the functional state of pituitary-thyroid units of neuroendocrinal regulation,...

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Autores principales:	Maria A. Rashidova, Leonid F. Sholokhov, Marina A. Darenskaya, Lyubov I. Kolesnikova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2019
Materias:	thyroid hormone lipid peroxidation antioxidant protection chronic viral hepatitis women reproductive age Science Q
Acceso en línea:	https://doaj.org/article/14c540a8dec0421ea7f1146a978d460d
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spelling	oai:doaj.org-article:14c540a8dec0421ea7f1146a978d460d2021-11-23T06:14:42ZFunctional State of the Thyroid Gland and Lipid Peroxidation and Antioxidant Protection System in Women of Reproductive Age with Chronic Form of Parenteral Viral Hepatitis2541-94202587-959610.29413/ABS.2019-4.1.5https://doaj.org/article/14c540a8dec0421ea7f1146a978d460d2019-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1975https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. Chronic viral hepatitis is a complex global problem and is still far from being solved. Many researchers point out influence of viral hepatitis on the reproductive system of women.Aim. To identify features of the functional state of pituitary-thyroid units of neuroendocrinal regulation, and to evaluate lipid peroxidation – antioxidant protection with determination of the oxidative stress coefficient in perimenopausal women with chronic form of hepatitis.Materials and methods. Study included 44 women with chronic viral hepatitis and 28 healthy women of the same age. Immunoabsorbent, spectrophotometric, fluorometric and statistical methods were used.Results. In patients with chronic viral hepatitis, we detected an increase in thyroxine levels – by 29.6% (р < 0.001) and free triiodothyronine values – by 65.7% (р = 0.008) in comparison with the control group. In the group with chronic viral hepatitis, the TBA-reactive products level increased by 1.9 times (р = 0.006), and superoxide dismutase activity decreased by 1.3 times (р < 0.001), total antioxidant activity – by 1.7 times (р < 0.001) and α-tocopherol level – by 1.3 times (р = 0.005) in comparison with the control group.Conclusions. The obtained data demonstrate the features of the pituitary-thyroid system functioning and the lipid peroxidation – antioxidant protection system in patients with chronic hepatitis. The chronic form of hepatitis is characterized by metabolic disorders that require a more careful approach in diagnosis and management.Maria A. RashidovaLeonid F. SholokhovMarina A. DarenskayaLyubov I. KolesnikovaScientific Сentre for Family Health and Human Reproduction Problemsarticlethyroid hormonelipid peroxidationantioxidant protectionchronic viral hepatitiswomenreproductive ageScienceQRUActa Biomedica Scientifica, Vol 4, Iss 1, Pp 31-35 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	thyroid hormone lipid peroxidation antioxidant protection chronic viral hepatitis women reproductive age Science Q
spellingShingle	thyroid hormone lipid peroxidation antioxidant protection chronic viral hepatitis women reproductive age Science Q Maria A. Rashidova Leonid F. Sholokhov Marina A. Darenskaya Lyubov I. Kolesnikova Functional State of the Thyroid Gland and Lipid Peroxidation and Antioxidant Protection System in Women of Reproductive Age with Chronic Form of Parenteral Viral Hepatitis
description	Background. Chronic viral hepatitis is a complex global problem and is still far from being solved. Many researchers point out influence of viral hepatitis on the reproductive system of women.Aim. To identify features of the functional state of pituitary-thyroid units of neuroendocrinal regulation, and to evaluate lipid peroxidation – antioxidant protection with determination of the oxidative stress coefficient in perimenopausal women with chronic form of hepatitis.Materials and methods. Study included 44 women with chronic viral hepatitis and 28 healthy women of the same age. Immunoabsorbent, spectrophotometric, fluorometric and statistical methods were used.Results. In patients with chronic viral hepatitis, we detected an increase in thyroxine levels – by 29.6% (р < 0.001) and free triiodothyronine values – by 65.7% (р = 0.008) in comparison with the control group. In the group with chronic viral hepatitis, the TBA-reactive products level increased by 1.9 times (р = 0.006), and superoxide dismutase activity decreased by 1.3 times (р < 0.001), total antioxidant activity – by 1.7 times (р < 0.001) and α-tocopherol level – by 1.3 times (р = 0.005) in comparison with the control group.Conclusions. The obtained data demonstrate the features of the pituitary-thyroid system functioning and the lipid peroxidation – antioxidant protection system in patients with chronic hepatitis. The chronic form of hepatitis is characterized by metabolic disorders that require a more careful approach in diagnosis and management.
format	article
author	Maria A. Rashidova Leonid F. Sholokhov Marina A. Darenskaya Lyubov I. Kolesnikova
author_facet	Maria A. Rashidova Leonid F. Sholokhov Marina A. Darenskaya Lyubov I. Kolesnikova
author_sort	Maria A. Rashidova
title	Functional State of the Thyroid Gland and Lipid Peroxidation and Antioxidant Protection System in Women of Reproductive Age with Chronic Form of Parenteral Viral Hepatitis
title_short	Functional State of the Thyroid Gland and Lipid Peroxidation and Antioxidant Protection System in Women of Reproductive Age with Chronic Form of Parenteral Viral Hepatitis
title_full	Functional State of the Thyroid Gland and Lipid Peroxidation and Antioxidant Protection System in Women of Reproductive Age with Chronic Form of Parenteral Viral Hepatitis
title_fullStr	Functional State of the Thyroid Gland and Lipid Peroxidation and Antioxidant Protection System in Women of Reproductive Age with Chronic Form of Parenteral Viral Hepatitis
title_full_unstemmed	Functional State of the Thyroid Gland and Lipid Peroxidation and Antioxidant Protection System in Women of Reproductive Age with Chronic Form of Parenteral Viral Hepatitis
title_sort	functional state of the thyroid gland and lipid peroxidation and antioxidant protection system in women of reproductive age with chronic form of parenteral viral hepatitis
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2019
url	https://doaj.org/article/14c540a8dec0421ea7f1146a978d460d
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Functional State of the Thyroid Gland and Lipid Peroxidation and Antioxidant Protection System in Women of Reproductive Age with Chronic Form of Parenteral Viral Hepatitis

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