Asymmetric counteranion-directed Lewis acid organocatalysis for the scalable cyanosilylation of aldehydes

Asymmetric cyanosilyation is a powerful method to convert carbonyls to chiral, configurationally stable cyanohydrins. Here, the authors report a catalyst capable of carrying out this reaction on large scales with extremely low catalyst loading, and also identify and explain a dormant period in the c...

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Autores principales: Zhipeng Zhang, Han Yong Bae, Joyram Guin, Constantinos Rabalakos, Manuel van Gemmeren, Markus Leutzsch, Martin Klussmann, Benjamin List
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/14c5c2fe915f4d278e64b0b1946afdfa
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Sumario:Asymmetric cyanosilyation is a powerful method to convert carbonyls to chiral, configurationally stable cyanohydrins. Here, the authors report a catalyst capable of carrying out this reaction on large scales with extremely low catalyst loading, and also identify and explain a dormant period in the cycle.