Asymmetric counteranion-directed Lewis acid organocatalysis for the scalable cyanosilylation of aldehydes

Asymmetric cyanosilyation is a powerful method to convert carbonyls to chiral, configurationally stable cyanohydrins. Here, the authors report a catalyst capable of carrying out this reaction on large scales with extremely low catalyst loading, and also identify and explain a dormant period in the c...

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Autores principales:	Zhipeng Zhang, Han Yong Bae, Joyram Guin, Constantinos Rabalakos, Manuel van Gemmeren, Markus Leutzsch, Martin Klussmann, Benjamin List
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/14c5c2fe915f4d278e64b0b1946afdfa
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spelling	oai:doaj.org-article:14c5c2fe915f4d278e64b0b1946afdfa2021-12-02T17:31:35ZAsymmetric counteranion-directed Lewis acid organocatalysis for the scalable cyanosilylation of aldehydes10.1038/ncomms124782041-1723https://doaj.org/article/14c5c2fe915f4d278e64b0b1946afdfa2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12478https://doaj.org/toc/2041-1723Asymmetric cyanosilyation is a powerful method to convert carbonyls to chiral, configurationally stable cyanohydrins. Here, the authors report a catalyst capable of carrying out this reaction on large scales with extremely low catalyst loading, and also identify and explain a dormant period in the cycle.Zhipeng ZhangHan Yong BaeJoyram GuinConstantinos RabalakosManuel van GemmerenMarkus LeutzschMartin KlussmannBenjamin ListNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhipeng Zhang Han Yong Bae Joyram Guin Constantinos Rabalakos Manuel van Gemmeren Markus Leutzsch Martin Klussmann Benjamin List Asymmetric counteranion-directed Lewis acid organocatalysis for the scalable cyanosilylation of aldehydes
description	Asymmetric cyanosilyation is a powerful method to convert carbonyls to chiral, configurationally stable cyanohydrins. Here, the authors report a catalyst capable of carrying out this reaction on large scales with extremely low catalyst loading, and also identify and explain a dormant period in the cycle.
format	article
author	Zhipeng Zhang Han Yong Bae Joyram Guin Constantinos Rabalakos Manuel van Gemmeren Markus Leutzsch Martin Klussmann Benjamin List
author_facet	Zhipeng Zhang Han Yong Bae Joyram Guin Constantinos Rabalakos Manuel van Gemmeren Markus Leutzsch Martin Klussmann Benjamin List
author_sort	Zhipeng Zhang
title	Asymmetric counteranion-directed Lewis acid organocatalysis for the scalable cyanosilylation of aldehydes
title_short	Asymmetric counteranion-directed Lewis acid organocatalysis for the scalable cyanosilylation of aldehydes
title_full	Asymmetric counteranion-directed Lewis acid organocatalysis for the scalable cyanosilylation of aldehydes
title_fullStr	Asymmetric counteranion-directed Lewis acid organocatalysis for the scalable cyanosilylation of aldehydes
title_full_unstemmed	Asymmetric counteranion-directed Lewis acid organocatalysis for the scalable cyanosilylation of aldehydes
title_sort	asymmetric counteranion-directed lewis acid organocatalysis for the scalable cyanosilylation of aldehydes
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/14c5c2fe915f4d278e64b0b1946afdfa
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Asymmetric counteranion-directed Lewis acid organocatalysis for the scalable cyanosilylation of aldehydes

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